Ensuring the future of Atlantic bluefin tuna | PNAS Atlantic bluefin tuna (ABT) are a highly migratory fish that have been exploited by fishers for more than two millennia. This lucrative fishery is ...

Ensuring the future of Atlantic bluefin tuna | PNAS www.pnas.org/doi/10.1073/.... 🧪. Great news about the recovery of bluefin that was once near the brink of extinction

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging - Nature Communications Mitochondrial decline impairs late-life metabolic plasticity. Using nematodes and human data, this study identifies reduced phosphatidylcholine synthesis as a natural trigger of mitochondrial dysfunct...

www.nature.com/articles/s41... 🧪 interesting article.

academic.oup.com/pnasnexus/ad... 🧪 cool article for in situ monitoring of crystal growth

Mammography should include artificial intelligence support In the past decade, deep learning has increasingly been applied to medical image interpretation, but without consensus as to whether medical practice should change. Many studies show artificial intell...

Mammography should include artificial intelligence support - The Lancet www.thelancet.com/journals/lan.... 🧪 yes!

Dental Flossing May Lower the Risk for Incident Ischemic Stroke, Cardioembolic Stroke Subtype, and Atrial Fibrillation | Stroke BACKGROUND: Prior studies have demonstrated an association between oral infection and both incident stroke and atrial fibrillation (AF), a major cause of cardioembolic stroke. However, the impact of p...

www.ahajournals.org/doi/10.1161/... 🧪 another good reason to floss every day.

An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease - Genome Biology Background As the first organ to develop in utero, the human heart undergoes extensive molecular, structural and metabolic remodeling during development and must sustain its function throughout life. ...

link.springer.com/article/10.1.... 🧪 analysis reveals
reactivation of fetal processes in diseased human heart and researchers
generated a comprehensive, cell-type–specific enhancer-to-gene regulatory map that
prioritizes downstream genes as mediators of dilated and hypertrophic cardiomyopathy.

Computational microbiology: Where is artificial intelligence addressing the barriers to large-scale simulations of bacterial cell envelopes? Molecular dynamics simulations allow the investigation of the time-resolved mechanics of large, complex biological systems such as the Gram-negative b…

www.sciencedirect.com/science/arti... 🧪 great review and recommend next steps

Cavir: confidence-aware vision-based registration for image-guided surgery - International Journal of Computer Assisted Radiology and Surgery Purpose Surgical navigation depends on precise image-to-patient registration, yet line-of-sight issues on the tracker, anatomy deformation, and occlusion from instruments and the surrounding environme...

link.springer.com/article/10.1.... 🧪 interesting article

Magnetic friction defies centuries-old law – Physics World Sensing and programmable metamaterials could benefit from discovery

New experiments have overturned a simple law of friction that has held for over 300 years. 🧪⚛️ ow.ly/BbVg50YzEv1

If you are interested in the impact of the Office of Data Science Strategy through our partnership with NIH Institutes, please check out my blog🧪

datascience.nih.gov/director/spotlighting-odss-collaborations-nih-institutes-centers-and-offices-fiscal-year-2025

Single-cell spatial transcriptomic analysis of human skin anatomy - Nature Genetics This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and disease...

www.nature.com/articles/s41.... Cool paper revealing spatial gradients across centrifugal, anterior–posterior and craniocaudal body axes, identifying immune cell enrichment in flexural regions and papillary fibroblast enrichment in the sole, knee and elbow, correlating with increased thickness.

Supported by our office 🧪link.springer.com/article/10.1186/s12936-0...

We are thrilled to announce our second keynote speaker for #BOSC2026: Eric Green, the Chief Medical Officer at Illumina. Dr. Green was a key architect of the Human Genome Project and led the National Human Genome Research Institute (NHGRI) for 15 years.
More info: www.open-bio.org/events/bosc-...

The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis There was some evidence that cannabinoids can reduce symptoms of cannabis use disorder, insomnia, tic or Tourette's syndrome, and autism spectrum disorder, but the quality of this evidence was general...

The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis - The Lancet Psychiatry www.thelancet.com/journals/lan.... Findings indicate use of cannabinoids for treatment of mental disorders is rarely justified.

Sub‐Neuronal Network Profiling of Extracellular Vesicle Release Using a Compartmentalized Neurofluidic Platform This study employs a compartmentalized neurofluidic platform to map extracellular vesicle (EV) secretion dynamics with the aim of increasing the spatial resolution at sub-neuronal locations. It exami....

Sub‐Neuronal Network Profiling of Extracellular Vesicle Release Using a Compartmentalized Neurofluidic Platform - Malkoc - 2026 - Advanced Biology - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/... supported by my office researchers monitor EV secretion at subcellular resolution

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Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing Our ability to produce human-scale biomanufactured organs is limited by inadequate vascularization and perfusion. For arbitrarily complex geometries, designing and printing vasculature capable of adeq...

Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing | Science www.science.org/doi/10.1126/... by my office researchers developed a model-driven design platform to design vasculature trees for organ or tissue mimetic including flow patterns and pressure.

Supported by my office 🧪

A little more information about the Multimorbidity in Africa: Digital Innovation Visualisation and ApplicationResearch Hub (MADIVA).
informatics.bmj.com/content/32/1/e…,

Supported by my office doi.org/10.1161/CIRC...

Illustrates the need for enriched screening strategies for Lp(a) testing in a selective populations. 🧪

Sensitivity and Uncertainty Analyses for Model of Olfaction using Dempster-Shafer Theory and Neural Networks Olfactory systems in arthropods rely on arrays of chemosensory hairs (sensilla) that interact with the surrounding fluid to capture odor cues. The flu…

www.sciencedirect.com/science/arti... 🧪. Interesting read on epistemic uncertainty quantification

I am very sorry to learn that Phil Bourne passed away yesterday March 8. He had a huge impact at NIH and in the data science community.

He was also a good mentor to many people including me.
🧪

Merlin: a computed tomography vision–language foundation model and dataset - Nature Merlin, a vision–language foundation model trained on a large dataset of paired CT scans, patient record data and radiology reports, demonstrates strong performance across model architectures, di...

www.nature.com/articles/s41.... Just out. It’s a 3D VLM that learns from volumetric CT scans, electronic health record data and radiology reports.

Confounding factors and biases abound when predicting molecular biomarkers from histological images - Nature Biomedical Engineering This study shows that biomarker prediction accuracy from whole-slide images can reflect confounding by codependent biomarkers and correlated variables, suggesting that models may not learn the intende...

www.nature.com/articles/s41... 🧪 researchers show that current ML and graph based approaches fail to learn biomarker-specific genotype–phenotype mapping; instead, they exploit aggregated phenotypes of interdependent biomarkers or cohort-specific association as proxies for prediction.

Survivorship of modern total hip replacement to 30 years: systematic review, meta-analysis, and extrapolation of global joint registry data The estimated 92% 30-year survivorship of contemporary total hip replacement suggests that advances in bearing surface technology have greatly improved the long-term durability of total hip replacemen...

Survivorship of modern total hip replacement: systematic review, meta-analysis, and extrapolation of global joint registry data - The Lancet www.thelancet.com/journals/lan... 🧪 findings indicate roughly 92% 30 year survivorship suggests advances in bearing surface technology have improved.

Reconstruction of the lifeways of Central European Late Bronze Age communities using ancient DNA, isotope and osteoarchaeological analyses - Nature Communications Biomolecular insights into significant cultural changes during the Central European Late Bronze Age (1300–800 BCE) have been limited by cremation. Here, the authors examine available inhumation burial...

www.nature.com/articles/s41.... 🧪interesting

NetG2P: Network-based genotype-to-phenotype transformation identifies key signaling crosstalk for prognosis in pan-cancer study - BMC Biology Background Despite advances in whole-genome sequencing and identifying cancer-associated genetic alterations, understanding the influence of multiple genetic alterations collectively on cancer phenoty...

link.springer.com/article/10.1.... 🧪 Work uses AI
to translate the genomic information of patients with cancer into pathway interactions and cross-talk. A pan-cancer analysis finds distinct patterns of pathway
interaction networks among different cancer types and potential drug target.

Meta-analysis of genome-wide association studies of food allergy and IgE-sensitization

www.jacionline.org/article/S009... 🧪 This study identified 37 SNPs suggestively associated with food allergies and demonstrated genetic differences across phenotypes. It highlights the need for a unified food allergy definition.

A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA Antibody therapies can remove amyloid plaques from the brain and slow cognitive decline in people with Alzheimer's disease who are mildly impaired. These drugs are now being evaluated in participants ...

A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA - The Lancet Neurology www.thelancet.com/journals/lan...

Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact Cardiovascular medicine; Machine learning

Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact: iScience www.cell.com/iscience/ful... supported by our office study explored relationship between predicted impact of ncDNVs and sulcal pattern features among participants with CHD.

A roadmap for evaluating moral competence in large language models - Nature This Perspective offers a roadmap for tackling the challenges of the facsimile problem, moral multidimensionality and moral pluralism in large language models.

www.nature.com/articles/s41.... Thoughtful article and worth a read.