THAP1 is a maternal effect factor required for the first cell cycle via Rrm1 in early mouse embryos - EMBO Reports Maternal effect genes (MEGs) produce factors that accumulate in oocytes and play critical roles in embryo development. Mutations of MEGs are frequently linked to reproductive and congenital disorders....

link.springer.com/article/10.1...

Innovative applications of the EnderScope, a low-cost microscopy system What costs less than 300 Euros, weighs 1.8 kgs, fits into a 30 cm x 30 cm box, and can do a mosaic scan of a large area in brightfield and fluorescence? It’s the EnderScope, a low-cost, open source…

isn't that cool :
www.eurobioimaging.eu/news/innovat...

Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration The evolution and development of eyes are fundamental problems in biology, and numerous genetic and age-related degenerative eye diseases are still po…

Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration - Cell Reports
www.sciencedirect.com/science/arti...

Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!

For #FluorescenceFriday
Bicolored sebaceous glands, showing differential lectin reactivity, in the foxn1-null (nu/nu) skin.
#epidermis
#glycosylation

Following our international Spatial Omics in Plants workshop (January 2026), we’re continuing the momentum with a new online seminar series to keep this growing community connected.

The IHCIF Course is now open for registration!

Learn to design, validate & troubleshoot experiments with expert instructors and real lab experience.

📅 Oct 4-9, 2026
💲Financial aid is available – request upon registration

Spots are limited – apply early! www.mbl.edu/education/ad...

Perineural net-labeled cells (white), tyrosine hydroxylase-positive cells (red) and mitochondria labelling (magenta) in some cells of the periacqueductal gray region of a mouse brain

Getting into #FluorescenceFriday.

Interesting decorated perineural net cells surrounding the periacqueductal gray region, along with tyrosine hydroxylase-positive cells.

High-throughput phenomics of global ant biodiversity Nature Methods - Antscan is a publicly accessible database of synchrotron X-ray CT images of ants. The database covers almost 800 species from more than 200 genera and is coordinated with genome...

"Here, within the open science initiative ‘Antscan’, we applied high-throughput synchrotron X-ray microtomography to capture phenotypes across a diverse and ecologically dominant insect group: ants. www.antscan.info

rdcu.be/fabvI

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors In vivo delivery systems (IDSs) are designed to protect and transport therapeutics, but their clinical applications are hindered by low delivery efficiency. We identified gut microbiota as key regulat...

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors | Science www.science.org/doi/10.1126/...

L'ultimo dei maghi
@MarsilioEditori @adelphiedizioni.bsky.social

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis The hypothalamic-pituitary-gonadal axis (HPG) controls pubertal development, sexual maturation, and fertility. We identified a role of hypothalamic microglia in controlling the HPG axis through recept...

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis | Science www.science.org/doi/10.1126/...

Do you work with a strange model species and are frustrated by the lack of antibodies for immunos? Here's a web app that does some computational pre-screening for you.
sixpack-abscan.serve.scilifelab.se

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
rdcu.be/e7LqK

High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage The first lineage decision in mammalian development segregates embryonic and extra-embryonic fates, yet the timing of this specification remains under…

High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage
www.sciencedirect.com/science/arti...

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis
rdcu.be/e6qmL

An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut The gut is composed of a remarkable diversity of cells that, through diverse small-molecule receptors, sense a complex mix of diet-, self-, and microbial-derived molecules. Xu et al. leverage image-ba...

Spatial atlas of murine gut

Image-based transcriptomics inform cell-type expression & spatial organization of receptors sensing diet-, self- & microbial-derived molecules in murine gut. Work uncovers microbiota-dependent modulation of gut structure
www.cell.com/cell-host-mi...

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells Proper differentiation of gonadal somatic cells is crucial for sex determination and the production of sex hormones and gametes, and reconstituting this process in culture would both deepen our unders...

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells | Science www.science.org/doi/10.1126/...

In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! 🚨

Let me hit you with some highlights on why spatial structure matters. (and why you should care!)

Sharing is appreciated 🙏 🧵👇

doi.org/10.1093/fems...

Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Scalable spatial transcriptomics through computational array reconstruction - Nature Biotechnology An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale.

An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale go.nature.com/3QYfSDd
rdcu.be/e4Db0

A whole-brain single-cell atlas of circadian neural activity in mice The mammalian brain comprises numerous anatomical regions with distinct functions despite their extensive connectivity. How spontaneous neural activity is coordinated across regions over the circadian...

A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...

Loke CTR Annual Meeting 2026 - Epigenetics of embryogenesis and placentation | Loke Centre for Trophoblast Research Register for in-person Register for online The 2026 Loke CTR annual meeting theme, “Epigenetics of embryogenesis and placentation” brings together leading clinical and basic scientists to explore…

This July join us in Cambridge (or online) for our Annual Meeting 'Epigenetics of embryogenesis and placentation'

📅 16-17 July 2026
📍 St John’s College, Cambridge, UK (in-person or full programme available online)

👉 Learn more and register here: www.trophoblast.cam.ac.uk/ctrconferences

Pregnancy-associated shifts in maternal microbiota across multiple body sites can signal to the placenta, influencing its function and fetal development.

Maternal microbial ecosystems are key in shaping reproductive physiology and pregnancy outcomes. While the gut microbiota has been extensively studied, the roles of microbes in other body regions are less clear. This #IAIJournal review provides insights: asm.social/2OQ

Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging - The EMBO Journal Sperm aging impacts male fertility and offspring health, highlighting the need for reliable aging biomarkers to guide reproductive decisions. However, the molecular determinants of sperm fitness durin...

link.springer.com/article/10.1...

Pregnancy is a miraculously odd state of existence defined by a slew of changes, including to the immune system. These shifts are linked to everything from food aversions to infections, with important implications for pregnancy outcomes. Read the article: asm.org/articles/202...

ICYMI

Single-cell and spatial transcriptomics unveils key regulators governing cell differentiation for Schistosoma sexual development
www.biorxiv.org/content/10.6...

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency Currently, no effective treatment exists for infertility associated with premature ovarian insufficiency (POI) because affected patients lack hormone-responsive antral follicles. By screening a Food a...

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency | Science www.science.org/doi/10.1126/...

Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe

@mibinet.bsky.social

#EMBOrnaLocalization

link.springer.com/article/10.1...

Integrins mediate symbiont-specific uptake in cnidarian larvae - EMBO Reports Endosymbiosis between dinoflagellate algae and cnidaria is fundamental for coral reef health. Appropriate symbiont selection is required for sufficient host nutrient acquisition and could be tailored ...

link.springer.com/article/10.1...