In this study we show that the toxin malleicyprol, produced by the pathogen Burkholderia pseudomallei, can be enzymatically inactivated via a cyclopropanol ring-opening. This provides new insight into how microbial toxins may be neutralized, opening a potential route for therapeutic intervention.

I’m happy to share that our latest work is now published and available open access in @angewandtechemie.bsky.social .

Many thanks to Ingrid Richter, Katharina Dornblut, Alicia, and Christian Hertweck for our excellent collaboration 🎉

onlinelibrary.wiley.com/doi/full/10....

Wow, what a blast. 🥳 Participated at the Paradies Triathlon Jena with my HKI colleagues—proud to say we took 3rd place at the mixed team competition!
🏊‍♀️Annika, 🚴@markgresnigt.bsky.social 🏃Me

I'm happy that our latest study has been accepted in @angewandtechemie.bsky.social! This work elucidates the final steps of malleicyprol biosynthesis.
A big thank you to all co-authors for their contributions to this project.
Full article: onlinelibrary.wiley.com/doi/10.1002/...