This was a large collaborative effort of many years spanning multiple continents and groups. Appreciate the help from everyone involved at @ucl.ac.uk , IoN, @crick.ac.uk , @blizardinstitute.bsky.social, University of Zagreb, @uottawa.ca and Chung-Ang University.

Hippocampal circuit-specific enhancement of GABA-inhibition caused by discrete gene regions in a Down syndrome model Although Down syndrome (DS), trisomy 21, affects ~6 million people worldwide, the neural circuit mechanisms underlying the neurophenotypes of impaired learning, memory and language are unknown. A prom...

For GABA circuit defects and gene dosage check out: www.biorxiv.org/content/10.1...

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome Down syndrome, caused by trisomy 21, affects around six million people worldwide and features learning, memory and language deficits. However, the mechanisms underlying trisomy 21 neurophenotypes invo...

For early network defects and K channels visit: www.biorxiv.org/content/10.1...

Exciting news in Down syndrome research! Two preprints out (links below). We uncover a K⁺ channel defect during development & show elevated #GABA signaling is circuit-specific - offering insight into failed #Roche GABA trial. Targeting specific K⁺ channels & GABA circuits will be beneficial in DS

This is sad news indeed. The way to make this count will be to learn from this every possible detail to help make the future safer for the others. Thoughts are with the family.

Saad Hannan Neuroscientist and pharmacologist studying neural inhibition and diseases

Our website is now online. For details of our work on GABAergic neurobiology, pharmacology, disease mechanisms and tech development plus more please visit www.saadhannan.com

Same here. Thanks