It all started with (#2 in the series)
New in Nature Methods - spontaneously blinking dyes for live cell super-resolution. No harsh chemicals or damaging light.
2 Nature family papers in two weeks π€―
@rhodamine110.bsky.social @sciencethecat.bsky.social
doi.org/10.1038/s415... doi.org/10.1038/s414...
Just out: A series of spontaneously blinking dyes for super-resolution microscopy
with @rhodamine110.bsky.social and an incredible team of collaborators.
www.nature.com/articles/s41...
It's been an amazing few weeks -- this follows our cytoplasmic tradewinds paper.
www.nature.com/articles/s41...
And this one took a whileβ736 days. I wrote about why there is more behind this paper than the chemistry. communities.springernature.com/posts/736-days
sOrganellomics is a new strategy to map cell state diversity and functional cell changes across healthy and diseased tissues! Check out the latest version now on BioRxiv - Congratulations @feliciano-lab.bsky.social !!
How do proteins find their way to the cell's leading edge? @jimgalbraith27.bsky.social & @cathygalbraith.bsky.social break down how bleach line, FLOP, single-particle tracking, FCS & iPALM reveal intracellular fluid flow and an actin-myosin compartment barrier. doi.org/10.1038/s414...
I'm happy to share a recent study by @cathygalbraith.bsky.social & James Galbraith, along with @sciencethecat.bsky.social & myself. It challenges existing views onΒ intracellular transportationβ¦ π www.nature.com/articles/s41...
What if cells have undiscovered methods for managing their internal logistics? Our recent work (@cathygalbraith.bsky.social, James A. Galbraith, @sciencethecat.bsky.social & myself) challenges existing views on intracellular transportation π lnkd.in/dhMDgY5Q
So excited to share this work that employs #FCS, TIRF, FRAP, SPT, SIM & #iPALM. Huge thanks to @cathygalbraith.bsky.social, James Galbraith, and @ulrikeboehm.bsky.social (the iPALM wizard) #OpenScience @hhmijanelia.bsky.social #CellBiology #Cytoskeleton #SuperResolution #Microscopy #Actin
Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort.
www.biorxiv.org/cgi/content/...
Max Planck Center for Physics and Medicine building
Max Planck Instittute for the Science of Light building
π¨New Lab Alert!π¨ Superhappy to announce that I will start my lab combining photonics & neuroscience at the Max Planck Center for Physics & Medicine in Erlangen & @mpi-scienceoflight.bsky.social in January 2027! Reach out if you're interested in internships, BSc, MSc & PhD & postdoc projects!
A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...
Cloud of words in various colors and sizes on a white background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
Cloud of words in various colors and sizes on a black background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
Cloud of words in various colors and sizes on a white background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
Brian Patrick English loves writing about cell, imaging, single, living, dynamic, molecules and probably posts about them here too @sciencethecat.bsky.social
Create yours at https://scholargoggler.com/
And in yesterday's journal club, we discussed this nice paper on transforming antibodies into intrabodies from @tim-stasevich.bsky.social et al. The authors put together a pipeline comprising ProteinMPNN to design a stabler protein sequence for the scaffold while keeping the antigen-binding loops.
Fluorescent dyes at the Lavis Lab at Janelia Research Campus
Beautiful, & built for discovery. These next-gen fluorescent dyes (developed by the Lavis Lab at our Janelia Research Campus) are brighter, more photostable, & more versatile β advancing how scientists visualize biology inside cells.
Pi-day opening at Cultivate Gallery: Heloisa's DIScomfort Beauty interactive installation @heloisarts.bsky.social #washingtondc #interactiveart #videoinstallation @cultivateprojects.bsky.social
This Saturday: art by my β₯οΈ Heloisa!
ππ π°πΆππΆπ»π΄ ππ²ππ²πΉπΌπ½πΊπ²π»ππ πΆπ» π πΆπ°πΏπΌππ°πΌπ½π π₯π²π½πΌπΏππΆπ»π΄! If you're involved in creating, processing, or publishing microscopy data, take a look at the new checklist for reporting requirements provided by @quarep-limi.bsky.social in @jcb.org π rupress.org/jcb/article/...
As a lifelong Bayern fan, I feel incredibly lucky to have a coach with this much class leading our team.
Bayern Munich head coach Vincent Kompany has said Jose Mourinho made a βhuge mistakeβ in accusing Vinicius Junior of inciting an incident that ended with the Real Madrid forward alleging racist abuse.
More from @sebsb.bsky.social and @colinmillar.bsky.social
www.nytimes.com/athletic/705...
Brasil sil sil sil
Lucas gets gold.
Bagunca Brasileiro
In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...
What an amazing opportunity to work on cutting edge biology and biophysics with a great mentor. Apply!!!!
Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt π to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...
on Holocaust Remembrance Day
Time by Luxmuralis at the Washington National Cathedral
Having grown up in a small Bavarian farming village of 600 people, itβs incredibly rewarding to finally be properly recognized. #Grassland #Pasture #MiaSanMia #MDPI
2025 "dumpster fire" gingerbread house made for the holiday season.
Gingerbread 2025 Dumpster π₯
Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"
www.janelia.org/content/lead...
Today I departed from @hhmijanelia.bsky.social knowing that the next time I come here, I will be a visitor.
Thank you all for having me. I will miss you a lot.
Holiday party 2025 @hhmijanelia.bsky.social
