Advertisement · 728 × 90

Posts by Sarah Cole

Thank you I would like all journal clubs to be in this format from now on 🙏🏻

1 year ago 1 0 0 0
Management, outcomes and predictors of mortality of Cryptococcus infection in patients without HIV: A multicentre study from Australia and New Zealand Coussement et al, 2024 | Clinical Infectious Diseases 426 patients without HIV diagnosed with cryptococcosis between 2015 and 2019 in Australia and New Zealand Use of induction therapy: Common in central nervous system cryptococcosis (99.5%, 192/193), typically with liposomal amphotericin + flucytosine (94%, 181/193), with mean duration 31 $ 13 days 27% of cases of isolated lung infection (i.e., azole antifungal as 1* line treatment in 73%, 120/166) Distinct outcomes of C. gattii infection: (versus C. neoformans) Lower mortality (adjusted odds ratio: 0.47, 95% C| 0.23-0.95, all-cause 1-year mortality: 11% for C. gattii vs. 28% for C. neoformans) Higher risk of immune reconstitution inflammatory response (21% vs 3% in central nervous system infection, p < 0.001) No microbiological relapses: None of 19 patients who had re-induction with amphotericin-based therapy for suspected relapse had confirmed microbiological relapse (i.e. positive culture) Central nervous system immune reconstitution inflammatory response seen in 16/426 patients (4%) At 1 year post-diagnosis, low rate of resolution of: serum cryptococcal antigen positivity (25% resolved) lung imaging abnormalities (34% resolved)

Management, outcomes and predictors of mortality of Cryptococcus infection in patients without HIV: A multicentre study from Australia and New Zealand Coussement et al, 2024 | Clinical Infectious Diseases 426 patients without HIV diagnosed with cryptococcosis between 2015 and 2019 in Australia and New Zealand Use of induction therapy: Common in central nervous system cryptococcosis (99.5%, 192/193), typically with liposomal amphotericin + flucytosine (94%, 181/193), with mean duration 31 $ 13 days 27% of cases of isolated lung infection (i.e., azole antifungal as 1* line treatment in 73%, 120/166) Distinct outcomes of C. gattii infection: (versus C. neoformans) Lower mortality (adjusted odds ratio: 0.47, 95% C| 0.23-0.95, all-cause 1-year mortality: 11% for C. gattii vs. 28% for C. neoformans) Higher risk of immune reconstitution inflammatory response (21% vs 3% in central nervous system infection, p < 0.001) No microbiological relapses: None of 19 patients who had re-induction with amphotericin-based therapy for suspected relapse had confirmed microbiological relapse (i.e. positive culture) Central nervous system immune reconstitution inflammatory response seen in 16/426 patients (4%) At 1 year post-diagnosis, low rate of resolution of: serum cryptococcal antigen positivity (25% resolved) lung imaging abnormalities (34% resolved)

Management, outcomes and predictors of mortality of Cryptococcus infection in patients without HIV: a multicentre study in 46 hospitals from Australia and New Zealand

academic.oup.com/cid/advance-... #IDSky #MedMycoSky

1 year ago 37 13 0 0

The menswear guy, but for antimicrobial regimens

1 year ago 91 14 7 6

Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).

Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!

1 year ago 91 17 20 2
Post image

Wake up babe, a new microbiology meme just dropped

#IDSky #MicroSky #MedSky

1 year ago 69 16 4 0