Society Melanoma Research Congress

The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research of international top investigators. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to network. Join us! smrcongress.org

Targeting eIF4G1-dependent translation in melanoma Elevated expression of components of eIF4F translation initiation complex has been documented in cancer, resulting in enhanced translation of mRNAs encoding pro-tumorigenic factors, including oncogeni...

Can one attenuate the eIF4F complex without toxicity? Read how we accomplished this complex task, enabling to overcome resistance to therapy and inhibit melanoma growth. work performed by Yongmei Feng (SBP discovery) in collaboration with exprests in McGill Univ. and Vancouver Prostate Centre

Age-associated modulation of TREM1/2- expressing macrophages promotes melanoma progression and metastasis Aging is a known risk factor for melanoma, yet mechanisms underlying melanoma progression and metastasis in older populations remain largely unexplored. Among the current knowledge gaps is how aging a...

Analysis of macrophages in melanoma metastasis of aged mice identified elevated expression of TREM2 (also seen in human melanoma). Inhibition of TREM2 blocked metastatic spread in preclinical mouse studies. Marzia Scortegagna led the study at SBP Discovery. Read more at: