We’re honored to be on the cover of @insight.jci.org this month! This work uncovers a key role for sympathetic nerve-CAF interactions in driving PDAC progression and remodeling the TME.

Thrilled to share our newly published work in JCI Insight! insight.jci.org/articles/vie...

Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer Gomez, Wu, et al. demonstrate that breast cancer promotes blunted glucocorticoid diurnal rhythms via disinhibition of PVNCRH neurons. Restoration of normal glucocorticoid rhythms via endogenous activa...

www.cell.com/neuron/fullt... new paper from our group demonstrating how breast tumors dysregulate rhythms in the HPA axis to drive their own growth. Great collaboration with the @corina-amor.bsky.social and @cheadlelab.bsky.social labs @cshlnews.bsky.social

Honored to join the @pcf-science.bsky.social Young Investigator, Class of 2025. Excited to continue advancing #spatialprofiling of the #prostate #tumormicroenvironment to uncover new biomarkers and therapeutic strategies.

Congratulations to first author Kunlun Wang for his outstanding work and to our brilliant team for making this advance possible: Young Hwan Chang, Kaoutar Ait-Ahmad, Zachary Sims, Samuel Kupp, Eric Cramer, Zeynep Sayar, Gordon Mills, Melissa Wong.

Toward universal immunofluorescence normalization for multiplex tissue imaging with UniFORM Wang et al. introduce UniFORM, a universal normalization pipeline for multiplex tissue imaging. UniFORM applies automatic rigid landmark registration to align intensity distributions at both the featu...

Normalization of spatial proteomics data is a major barrier to translating these datasets into clinical practice. We present a universal normalization framework that harmonizes data across platforms, cancer types, and labs: www.cell.com/cell-reports...

CEDAR researcher: Ece Ekşi, Ph.D. | OHSU Foundation Ekşi and her team investigate how interactions between nerves and cancer happen at the molecular level, with the goal of preventing it.

CEDAR researcher: Ece Ekşi (@eksiece.bsky.social)

Dr. Ekşi's work uses advanced imaging and AI to analyze large datasets, increasing the understanding of cancer cell behavior and potentially leading to new treatment options:

Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip Organoid models are invaluable for studying organ processes in vitro, offering an unprecedented ability to replicate organ function. Despite recent advancements that have increased their cellular comp...

Exciting new method in #cancerneuroscience: we're modeling nerve-cancer interactions in 3D using microgels! This is a fun collab with the Bertassoni Lab, who's been doing amazing work with the Biofabrication Hub @ohsuknight.bsky.social. Check out their latest here: pubs.rsc.org/en/content/a...

CSHL holds first-ever cancer neuroscience course | Cold Spring Harbor Laboratory The brain controls the body, in large part, through nerves. So, what happens when nerves form new connections with tumors? How does the nervous system drive cancer progression? How do these interactio...

How do nerves influence cancer? CSHL is shaping the future of #CancerNeuroscience with the field’s first hands-on training course, equipping researchers with cutting-edge techniques that will help define the future of the field.

The best March 8 - with our #cancerneuroscience trainees at @cshlaboratory.bsky.social #womeninstem

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” - Cancer and Metastasis Reviews Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...

Need a distraction to shift your TMEntality today?
If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...

@cigdemak.bsky.social

opening new avenues for understanding the tumor microenvironment. Congratulations to first author Kaoutar Ait-Ahmad and the stellar multiplex imaging team at OHSU! #cancerneuroscience #prostatecancer #spatialprofiling #multipleximaging #neuronalinnervation

To address this gap, we introduce AxonFinder, a deep learning tool designed to accurately segment and quantify axons in prostate cancer. Leveraging a U-Net model with a ResNet-101 encoder, AxonFinder facilitates large-scale analysis of multiplexed imaging data,

AxonFinder: Automated segmentation of tumor innervating neuronal fibers Neurosignaling is increasingly recognized as a critical factor in cancer progression, where neuronal innervation of primary tumors contributes to the disease's advancement. This study focuses on segmenting individual axons within the prostate tumor microenvironment, which have been challenging to detect and analyze due to their irregular morphologies. We present a novel deep learning-based approach for the automated segmentation of axons, AxonFinder, leveraging a U-Net model with a ResNet-101 encoder, based on a multiplexed imaging approach.

Neurosignaling is recognized as a key factor in cancer progression, yet current spatial profiling approaches are unable to detect neuronal innervation in the TME. www.cell.com/heliyon/full...

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

SPATIAL PROTEOMICS is the Method of the Year 2024!!! 🤩🤩🤩

www.nature.com/articles/s41...

Could you please add me here as well? I work on cancer- neuron communication in the prostate TME. Thank you!

Thank you for putting this together! Could you please add me to the list?

Thank you for putting this together @andreasmoor.bsky.social I’d love to be added!

Methods in Cancer Neuroscience Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

The application deadline is on December 6th: meetings.cshl.edu/courses.aspx...

Whether you're a neuroscientist or a cancer biologist, this is the training you’ve been waiting for!

#cancerneuroscience

We're thrilled to invite you to apply for the upcoming Methods in Cancer Neuroscience course #coldspringharborlaboratory. This intensive course is an excellent opportunity to connect, grow, and dive into cutting-edge techniques and push the boundaries of cancer neuroscience.

#cancerneuroscience