Not just a harmless accessory, tau’s ‘fuzzy coat’ contributes to Alzheimer’s progression – Van Andel Institute Read about Not just a harmless accessory, tau’s ‘fuzzy coat’ contributes to Alzheimer’s progression on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in scien...

A study by @mxhend.bsky.social and collaborators found that an unstructured layer surrounding the Alzheimer’s-related protein tau plays a critical role in recruiting other proteins to misfold in Alzheimer’s progression. The findings were published in @natcomms.nature.com. www.vai.org/article/not-...

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency - Nature Communications Tau misfolds in Alzheimer’s disease, but how the link between tau filament structure and pathogenicity is unclear. This study shows that both filament core structure and phosphorylation in the fuzzy c...

I am happy to share that my doctoral work is now published in Nature Communications. I am grateful to all of the incredible scientists who contributed to this work.

I am excited to share that I have successfully defended my dissertation!

I am so greatful to my mentor, Dr. Mike Henderson, my Thesis Advisory Committee, our collaborators, and the members of the Henderson Lab who all helped me reach this milestone.

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency www.biorxiv.org/content/10.1101/2025.03....

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency Tau is a pathogenic protein in Alzheimer's (AD) and other neurodegenerative diseases. The misfolding of tau into beta-sheet rich elongated filaments is thought to be a key event in disease pathogenesi...

I am very excited to share the pre-print containing a majority of my dissertation work.

Another first place poster prize for graduate student @alysa-kasen.bsky.social for her work on tau pathology seeding! She is finishing up this summer and looking for a postdoc if anyone needs an excellent scientist!