FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com

Do you like microscopy? Do you think viruses are cool? Do you want to advance our understanding of one of the world's most important pathogens?

Come and do your PhD with myself and the fantastic @peacockflu.bsky.social, at @pirbrightinst.bsky.social and @cvrinfo.bsky.social

🤓🦠🐓

N*M210 inhibits SG/RLB formation by sequestering dsRNA. HeLa cells expressing N*M210-FLAG (blue) were transfected with poly (I:C) (pink) and SG/RLB formation was measured using TIAR (yellow). This experiment was conducted and imaged by Rory P Mulloy, who agrees to publish this image under a CC-BY licence.

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social
Details in the thread below - please share!
Deadline 8th May 2026, fully funded for UK Home students
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Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

💥 Paper published 💥

Curious how #SARS2 has changed since jumping into humans? We were too!

journals.plos.org/plosbiology/...

🧵 🧵 🧵

Also shout out to essential contributions from co-authors Noga Sharlin @nogasharlin.bsky.social who is now on bsky, Maxwell Bui-Marinos, Danyel Evseev, and our collaborators from the Flamand lab at Université Laval.

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

So proud to have worked alongside @rorymulloy.bsky.social and @corcoranlab.bsky.social on this amazing project, now out in @plosbiology.org!

journals.plos.org/plosbiology/...

N*M210 inhibits SG/RLB formation by sequestering dsRNA. HeLa cells expressing N*M210-FLAG (blue) were transfected with poly (I:C) (pink) and SG/RLB formation was measured using TIAR (yellow). This experiment was conducted and imaged by Rory P Mulloy, who agrees to publish this image under a CC-BY licence.

#SARSCoV2 has optimized its replication fitness in the human host. @rorymulloy.bsky.social @corcoranlab.bsky.social &co show that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @plosbiology.org 🧪 plos.io/3PIZMjr

Thanks @brucelab.bsky.social !

Super proud that this paper is out. Fascinating study on how SARS-CoV-2 evolved to make more of a truncated N protein to evade antiviral responses. Led by fantastic PhD candidate @rorymulloy.bsky.social and funded by CIHR and CoVaRR-Net.

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

journals.plos.org/plosbiology/...

Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.

New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods

This is an incredibly moving thread.

Protein-based tools for the detection and characterisation of Oropouche virus infection Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...

The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of:
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...

@rorymulloy.bsky.social et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans 👀. From: @corcoranlab.bsky.social www.biorxiv.org/content/10.1...

Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran

www.biorxiv.org/content/10.1...

thanks @ngrandvaux.bsky.social ! Fingers crossed on submission!

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...

Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...