A wonderful team effort with @tedpricethepainguy.bsky.social, @dianatavf.bsky.social and collaborators at Merck. This is a great example of collaboration across academia and industry. Grateful for the synergy that made this work possible.

Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity The paravertebral sympathetic chain ganglia (SCG) are autonomic ganglia critical for regulating the fight-or-flight response. Symptoms of sympathetic dysfunction are prevalent in diabetes, affecting u...

Excited to share our preprint on spatial transcriptomics of human sympathetic chain ganglia and the effect of diabetes. We also compared sympathetic and dorsal root ganglia to identify ganglia-specific signatures. Work led by @marisolmancilla.bsky.social

doi.org/10.1101/2025...

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the r…

Our collaborative paper with Isaac Chiu's lab was published today: www.sciencedirect.com/science/arti... It is a really cool finding on how Staphylococcus V8 protease drives the itch-scratch cycle via PAR1 activation. We did the human DRG work. Huge congrats to Liwen Deng, who led this work.

Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress re... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

We received positive reviews on our work on TMEM97 modulators for neuropathic pain and have now posted a revision to our paper on @biorxiv-neursci.bsky.social @biorxiv-bioinfo.bsky.social www.biorxiv.org/content/10.1... led by Saad Yousuf in my lab and Jim Sahn in Stephen Martin's lab at UT Austin