γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

Ever wondered why gamma delta T cells are required for immunity to liver-stage malaria?

www.nature.com/articles/s41...

γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

γδ T cell-derived IL-4 initiates CD8+ T cell immunity

#gdTcells @natimmunol.nature.com

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

Our third webinar from the AUS/APAC region, will feature Nick Gherardin and Sho Yamasaki. Thursday, June 12th at 17:00 AEST (8:00 London, 16:00 Tokyo).

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Role for γδ T cell-derived IL-4 in initiating CD8 T cell immunity to Plasmodium
doi.org/10.1101/2024...

😲🤩 Has a name yet??

SAVE THE DATES - Join us for CD1-MR1 2025, September 9-12 in Portland, Oregon!
Updates are on the website www.cd1mr1.com including Program at a Glance, Location and Venue details.

Thank u & great to connect again here Cliona! Indeed we've wondered then sifted through still-quite-conflicting lit on CD1dKOs, pre vs post activated NKT cells in hepatectomy. Also maybe functional subsets/lineages can compensate & muddle the phenotype, we could knock more of'em out simultaneously..

Many thanks to our collaborators across Unimelb MDHS, The Florey Institute, University of Queensland, Austin Health for providing tools, resources and discussion towards this study!

Conceptually, non-peer review'd diagram here: Within T cells at least, integrating thoughts posed by labs of P.Brennan, B.Jabri, perhaps the extent of tissue damage sensitivity could be a hallmark of the ‘T cell-innateness’ theory. tinyurl.com/ycy6dv24
tinyurl.com/bd6kxekk

Overall, these have implications to how we should (in certain contexts) move away from studying our T cell lineages in isolation, and the role of T cell IL-4 production that is now getting resurged attention.

Towards discussion, this sensing of damage metabolites may act to prevent excessive tissue inflammation and injury as a way to maintain tissue homeostasis from the explosive cytokine production from these innate-T cells, UNTIL there is cognate antigen for them involved.

Our data indicates that upon insult, release of tissue damage metabolites drives this P2RX7-mediated depletion of T-bet+ innate-T cells. Blocking this also uncovered more numbers & subsets (CD4 innate-like IFNg/IL-4++ anyone?) than we thought originally exists. Also raising the q of 'why them'?

This all started in the quest of trying to recover enough numbers of NKT/MAIT/gdT cells ex vivo, why do (some) of them die so easily?? We followed the literature & the correlation of P2RX7 (not other P2RX's) expression on innate-like T cells was a key, in both mice and humans.

Thanks for sharing our latest work @jexpmed.bsky.social ! We've uncovered that P2RX7 regulates unconventional T cells selectively, particularly subsets that co-produce IFN-γ & IL-4. Hoping this helps more discoveries in the role of these innate-like cells using inhibitors from the P2RX7/ARTC2 field.