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Posts by Ellen Murray

We previously engineered Saccharomyces cerevisiae through CRISPR-Cas9 integration to produce Ply511, a bacteriophage endolysin active against L. monocytogenes, showing the potential of engineered yeast to produce endolysins for biocontrol. In this study, we extended this approach to the probiotic yeast S. boulardii and directly compared the two yeasts as secretion hosts for Ply511. Using a simulated human gastrointestinal environment, we evaluated their ability to retain endolysin activity and reduce L. monocytogenes levels.

We previously engineered Saccharomyces cerevisiae through CRISPR-Cas9 integration to produce Ply511, a bacteriophage endolysin active against L. monocytogenes, showing the potential of engineered yeast to produce endolysins for biocontrol. In this study, we extended this approach to the probiotic yeast S. boulardii and directly compared the two yeasts as secretion hosts for Ply511. Using a simulated human gastrointestinal environment, we evaluated their ability to retain endolysin activity and reduce L. monocytogenes levels.

New paper from the CEB- @uminho.bsky.social & APC
๐„๐ฏ๐š๐ฅ๐ฎ๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐ญ๐ก๐ž ๐๐ž๐ฅ๐ข๐ฏ๐ž๐ซ๐ฒ ๐จ๐Ÿ ๐š๐ง ๐š๐ง๐ญ๐ข-๐‹๐ข๐ฌ๐ญ๐ž๐ซ๐ข๐š ๐ž๐ง๐๐จ๐ฅ๐ฒ๐ฌ๐ข๐ง ๐ฏ๐ข๐š ๐‚๐‘๐ˆ๐’๐๐‘-๐‚๐š๐ฌ๐Ÿ— ๐ž๐ง๐ ๐ข๐ง๐ž๐ž๐ซ๐ž๐ ๐ฉ๐ซ๐จ๐›๐ข๐จ๐ญ๐ข๐œ ๐‘บ๐’‚๐’„๐’„๐’‰๐’‚๐’“๐’๐’Ž๐’š๐’„๐’†๐’” ๐’ƒ๐’๐’–๐’๐’‚๐’“๐’…๐’Š๐’Š
Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social

1 month ago 4 3 1 0
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๐Ÿ“ข Final reminder to apply for ISAPP 2026 in Tokyo, Japan!

Please ensure your abstract is submitted by midnight (GMT) tonight (Monday, 23 February 2026).

๐Ÿ”— www.isapp-sfa.com/tokyo-2026

1 month ago 1 1 0 0
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Probiotic yeast Saccharomyces boulardii is gaining attention for its unique traits and engineering potential. Could it power the next generation of therapeutic probiotics? Learn more in our latest ISAPP-SFA blog๐Ÿ”ฌ @isappscience.bsky.social

๐Ÿ“– www.isapp-sfa.com/new-blog/202...

7 months ago 1 3 0 0
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This year marked my first @isappscience.bsky.social annual meeting as part of the @isappsfa.bsky.social executive committee (Communications)
Brilliant science, thoughtful discussion, and great company throughout.
A huge thank you to my fellow committee members, Iโ€™m already excited for next year!
๐Ÿซถ๐Ÿผ

8 months ago 2 1 1 0
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SFA Talks from @Kristinacampbell, Sean Gibbons, and Howard Bauchner offered invaluable wisdom on science communication, career development, and strategies for publishing in high-impact journals! ๐Ÿ™Œ #ISAPP2025

9 months ago 3 3 0 0
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Are you up to date on our SFA blogs?๐Ÿ‘€

Visit our website to check out a catalogue of great blog posts from "Confessions of a Final Year PhD student" to "Gastrointestinal Motility: The Dynamic Conductor of the Gut Ecosystem" ๐Ÿ“š

Join the SFA at isapp-sfa.com/member-regis...

9 months ago 1 1 0 0
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Networking at meetings can sometimes be an overwhelming task, but at ISAPP 2024 Caroline Dricot found connections over scientific discussions, a brewery tour, and even an impromptu Irish dance! ๐Ÿค

Read about her experience in our latest blog๐Ÿ‘‡

๐Ÿ“– www.isapp-sfa.com/new-blog/202...

1 year ago 2 2 1 0
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โš ๏ธLast chance to apply!

Abstract submissions for the ISAPP-SFA annual meeting meeting close TODAY! ๐Ÿ‘

Don't miss this amazing opportunity. Sign up for ISAPP-SFA membership and send in your abstract now! ๐Ÿ‘‡

๐Ÿ”—isapp-sfa.com/member-registration-2024
๐Ÿ”—isapp-sfa.com/submit-abstract-banff-2025

1 year ago 1 1 1 0

This month's ISAPP-SFA blog post by Breanna Metras presents FoodSeq, a method for assessing diet diversity by analysing plant DNA in stool samples๐ŸชดRead the full blog to learn more!

๐Ÿ“– www.isapp-sfa.com/new-blog/202...

๐Ÿ”—Register for the ISAPP-SFA here: www.isapp-sfa.com/member-regis...

1 year ago 2 2 0 0
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Member registration 2025 โ€” ISAPP Students and Fellows Association

โœจSFA Membershipโœจ

To join/renew your membership, fill out our registration form (there's no fee to join).

isapp-sfa.com/member-regis...

SFA Membership allows you to connect with an amazing network of ECRs, keep up to date on SFA blogs & events and the opportunity to attend our annual meetings!๐ŸŒ

1 year ago 3 2 0 0