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#Alzheimer #Harvard

This is figure 5, which shows the therapeutic efficacy of a plaque-evading lithium salt.

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪

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Just found this quote from 1791. As true today as ever.

“You count on the force of truth; but truth is all-powerful only over minds accustomed to recognize it and cherish its noble accents.”
—Marquis de Condorcet

1/2 My gut feeling says that this time is real:
A blast from this @Nature paper. Lithium deficiency might be a driver of #Alzheimer's disease. Li depletion impedes amyloid clearance, repletion in humans could be achieved with low doses: nature.com/articles/s41... #dementia pic.x.com/LLis15fa9kht...

Is the endogenous lithium elemental, or bound with a chemical group (such as carbonate or orotate) in the form of a salt?

Firing the BLS Commissioner — the wonk in charge of the statisticians who track economic reality — is an authoritarian four alarm fire.

It will also backfire: You can't bend economic reality, but you can break the trust of markets. And biased data yields worse policy.

I was 6 when the Corporation for Public Broadcasting was founded in 1967, so my whole conscious life has been enriched by its work.
So many thanks to the good and creative people who worked hard to try and educate and enlighten us all.

orange cat lying on floor with square lights reflected on his flank that resembles lit windows

live action catbus looking pretty sweet

Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer’s disease models - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer’s disease models

Dongsheng Wang, Andrei Chernov, Ryan Lam, et al. @ucsdmedschool.bsky.social have developed a gene therapy for #Alzheimers that could help protect brain from damage & preserve cognitive function.

Signal Transduction and Targeted Therapy @natureportfolio.nature.com www.nature.com/articles/s41...

IEA data shows global demand growth for oil has been eliminated for road transport and is declining for aviation and shipping and is now negative for other sources. Additional demand growth remains in aviation and as petro-chemical feedstocks.

This IEA graphic shows how global sales of electric vehicles & improved efficiency of combustion vehicles (eg hybrids) is slashing growth in global oil demand. Use in road transport has peaked & likely to soon post annual declines. Aviation & petro-chemical feedstocks only drivers of growth now.🔌💡🔌🚗

Carrier debuts residential heat pump for cold climates The U.S. heating specialist said its new heat pump system can operate "reliably" at -30 C and achieve 100% heating capacity at -17 C, with full cooling capacity being achievable at 50 C.

A new Carrier home heat pump is designed for cold (and hot) climates: "The new product is also claimed to operate “reliably” at -30 C (-22 F) and to achieve 100% heating capacity at -17 C (1 F), with full cooling capacity being achievable at 50 C (122 F)." www.pv-magazine.com/2025/06/05/c... 🔌💡

Targeting inflammation with chimeric antigen receptor macrophages using a signal switch - Nature Biomedical Engineering Anti-TNF CAR macrophages show anti-inflammatory efficacy in both acute and chronic inflammatory disease mouse models.

Cells as living drugs is a big part of future medical approaches.
There's been so much about engineering T cells (CAR-T) for treatment of cancer and autoimmune diseases. But engineering macrophages (CAR-M) is next up for blocking inflammation.
www.nature.com/articles/s41...

The National Park Service has restored the changes to its website about the Underground Railroad following public outcry www.nps.gov/subjects/und...

This from @cnn.com is how you do it.

Russia’s leaders have said nothing about peace. They have made a list of demands on the US, the fulfillment of which allows them to broaden the war against Ukraine. And the US simply fulfills all of these Russian demands without question. That is only a peace process in the Orwellian sense.

Cover of “The Economist” showing Donald Trump holding a $100 bill that is smoldering in one hand and a gas tank in the other, on top of a sea of $100 bills.

•••BREAKING •••
A second federal judge has indefinitely blocked Trump’s sweeping freeze on federal grants and loans, saying the administration “put itself above Congress.”

“The Executive’s categorical freeze of appropriated and obligated funds fundamentally undermines…

This is a great example of what real resistance to fascism can look like. 👏 Let’s make sure the GOP is held accountable.

Senator Tina Smith said: This is the ultimate dick boss move from Musk - except he isn’t even the boss, he’s just a dick. That was in response to Musk saying “Consistent with President @realDonaldTrump's instructions, all federal employees will shortly receive an email requesting to understand what they got done last week. Failure to respond will be taken as a resignation.” Musk responded @SenTinaSmith “What did you get done last week?”

Elon, I hate to break it to you but you aren’t my boss. I answer to the people of Minnesota.

But since you bring it up, I spent last week fighting to stop tax breaks for billionaires like you, paid for by defunding health care for moms and babies

@elonmusk: Consistent with President @realDonaldTrump's instructions, all federal employees will shortly receive an email requesting to understand what they got done last week. Failure to respond will be taken as a resignation.

This is the ultimate dick boss move from Musk - except he isn’t even the boss, he’s just a dick.

Facebook post outlining the firing of 220,000 probationary federal employees in the US.

A recent Facebook post from a friend at USDA. This is heartbreaking.

The best messaging is to state what everyone knows to be the truth in the simplest and clearest way possible.

So it’s hard to imagine more effective messaging than this.

Orthographic map showing 2-m air temperature anomalies in January 2025 relative to a 1981-2010 baseline. This visualization shows North and South America. Most areas are warmer than average, except for the lower 48 USA.

Orthographic map showing 2-m air temperature anomalies in January 2025 relative to a 1981-2010 baseline using ERA5 data. This visualization shows Australia, Antarctica, and Asia. Most areas are warmer than average.

Last month was the warmest January on record globally! Outside of the contiguous United States, most continental land regions were much warmer than average.

Summary of the month at climate.copernicus.eu/surface-air-... using @copernicusecmwf.bsky.social ERA5 data.

This ⬇️⬇️⬇️

In the background is a large modern building - Meta headquarters in the UK. In the foreground is a flatbed electric truck with a sign that reads: We fact check the Zuck out of our news.

So Channel 4 (UK) drove this flatbed truck to Meta headquarters in response to their axing fact checkers. Brilliant. Absolutely brilliant

A goodly portion of history's religions, philosophies, & grand theories of all sorts have been part of a common genre: stories to justify why the particular group of men in charge deserve their power.

The divine right of kings. History's dialectic. And now, these days ... "meritocracy."