IN A FEW WORDS essay by Jonathan S. Pollack: The Roller Coaster Ride of IgA Nephropathy

bit.ly/4vFDAas (FREE)

a close up of a person 's stomach with a spider crawling on it Alt: a close up of a person 's stomach with a spider crawling on it

Sibeprenlimab injection #4.

#IgANephropathy #NephSky

Same.

I gained 5 lbs. going on, took it off rapidly after tapering. But that's the only side effect I experienced, AFAIK.

So are we supposed to stop brushing our teeth now?

How long until my insurance company sneaks in the generic?

B-Cell treatments are 100% going all the way.

Glad you don't have a problem with boils.

A delightful surprise, no doubt!

Look who’s staring at me in clinic today @jonathanpollack.bsky.social

Oh, I know. I know. Even being near somebody who has cats causes a reaction (suffering from one this morning due to a Passover seder seating situation last night).

I am thankfully not allergic to my pet chickens.

My extreme allergies respectfully disagree.

There are worse things than a dragon-based Haggadah.

Stef used to roll her own but some family members didn't like its inclusive nature and social commentary.

The debate rages on.

This is not at all surprising, and it lends support for other combination therapies that have different mechanisms of action and targets. www.kireports.org/article/S246...

#NephSky #IgANephropathy #IgAN

Always, always, always.

Yes/No

However it's labeled, it's good stuff and should be available everywhere as an option in the arsenal. Huge fan of my experience on it.

It has a built-in fan, you'd love it.

Aren't they the same thing? I guess it depends what type of enteric coating is on it.

a bizarre glucagon mascot on stage at a conference

My personal experience is that sibe prevented AKI during my February COVID infection. eGFR has remained stable, UPCR is now at 0.087 g/g with combination therapy. I think the future is going after Hit 1 (0? -1?) to really lock in eGFR slope and halt progression and insurers are starting to get it.

Cat allergies got me again. I wish there were a way to scratch inside of my sinuses.

Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy Galactose-deficient IgA1 (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), but the location of the plasma cells responsible for its production remain unknown.

Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy

www.kidney-international.org/article/S008...

I hope having my voice amplified by @ajkd.bsky.social will help clinicians and patients.

#IgANephropathy #IgAN #NephSky #MedSky

A little something I wrote about the patient perspective of disease: www.sciencedirect.com/science/auth...

#IgANephropathy #IgAN #NephSky #MedSky

I thought I'd personally experience this with sibeprenlimab but shockingly the insurance company approved it right away.

Nov/Dec to present:

BUN 32→24
creatinine 2.66→2.48
eGFR 29→31
UPCR 0.125→0.087
sodium 139→139
potassium 4.3→4.4
CO2 28→27
calcium 9.9→9.5
phosphorus 3.4→3.4
albumin 4.4→4.5
A/G ratio 1.8→2.1
ALT 12→16
AST 11→19
hemoglobin 13.1→13.6
hematocrit 39.1→41.5
vitamin D 30→60
PTH 33→44

#NephSky