Precision from broad strokes: How the non-specific interactions of metabolites and macromolecules can regulate biology In a recent article in Nature, Zabala-Letona et al.1 propose that polyamines—small, positively charged metabolites—regulate RNA splicing by electrosta…

@schvartzman.bsky.social and I wrote a perspective on how dynamic metabolite-protein interactions can shape cell biology, and the open questions this raises about the broad roles of metabolism. It was fun to dig into Zabala-Letona, Carracedo et al.'s story as an example of this! tinyurl.com/4tcnrydm

Thanks @nickburton.bsky.social and @vai.org for hosting me on a great day of science! Incredible people and science in an amazing institute

I had a great conversation with Bowei Li (Meaning Medicine) on communicating science to different audiences, talking with patients about science and the increasing role of AI in medicine. Thanks Bowei for inviting me! whatisglobalhealth.podcasts.library.columbia.edu/podcast/mean...

Text on a teal background stating, "Today's Research Assistants. Tomorrow's Cure-Finders." with the logo of Fund Research Save Our Cures at the bottom.

Today's research assistants, tomorrow's cure-finders:
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.

Speak up: http://fundresearch.org

#SaveOurCures #ScienceEducation #FutureReady

Congrats KJ!!!

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!

Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.

See here:
www.sciencedirect.com/science/arti...

Amazing. Congrats Wilhelm

Congrats Felipe and co!!!

Check in at 12pm EST today @fnucleosome.bsky.social to hear our new story on how one metabolite regulates chromatin structure and function

This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu

Imposter syndrome at an all time high! 😬

Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

There are so many stories like this. A weird colony in a plate in the rubbish to penicillin, fly eyes to ras inhibitors, weird repetitive sequences in bacteria to CRISPR. We should have a daily column on how science made your life better. #fundscience

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial: Women, courage, and leadership

What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!

Nobel Prize Winner Dr James Allison Discusses the Need to Fund More Fundamental Science Major discoveries only happen when there is funding for fundamental science, said James Allison, PhD, chair of the Department of Immunology, the Vivian L. Smith Distinguished Chair in Immunology, dire...

www.ajmc.com/view/nobel-p...

A patient reminded me of science’s power: 2 doses of immunotherapy and a fatal cancer GONE. Immunotherapy exists BECAUSE of basic research—work that can seem esoteric or wasteful. Before dismissing it, ask a scientist why it matters. Or ask the Nobel who discovered immunotherapy.

Congrats HaGe! Great to see this out

rupress.org/jcb/article/... A great piece on the life of Joe Gall, a giant of modern cell and molecular biology. Especially 👍 to the importance of exploring nature, model systems and supporting women in science. Really inspiring

Looking forward to your visit!

Could you add our lab?

Congrats on a great story Rich!

Division of labour: mitochondria split to meet energy demands Mitochondria divide into subpopulations to segregate metabolic processes.

AND with accompanying News and Views by Lena Pernas nature.com/articles/d41... AND video explaining the findings by Craig Thompson

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...

posting here since bsky is taking off!
nature.com/articles/s41586-024-08146-w Congratulations to my good friend @keunwooryu.bsky.social and the Craig Thompson lab on uncovering metabolically distinct mitochondrial subpopulations. Really cool cell biology Keun!!

A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria Eukaryotic cell function and survival rely on the use of a mitochondrial H+ electrochemical gradient (Δp), which is composed of an inner mitochondrial…

As my postdoctoral mentor likes to say: "cells didn't read your textbook!". A perfect example: www.sciencedirect.com/science/arti... . Just wow!!