Impact of control selection strategies on GWAS results: a study of prostate cancer in the UK Biobank Abstract. As genome-wide association studies (GWAS) studies move from array-based genotyping to whole exome and genome sequencing, there is a significant i

Glad to share my first manuscript "Impact of control selection strategies on GWAS results: a study of prostate cancer in the UK Biobank" published in BIB.
Thanks to @harrygreentkd.bsky.social @johanthygesen.bsky.social @rnbeaumont.bsky.social @mnweedon.bsky.social for their support and collaboration

Metabolomic, genetic, imaging data and more: new and updated UK Biobank data now available The latest update to UK Biobank’s comprehensive dataset is available to approved researchers around the world via the Research Analysis Platform (UKB-RAP).

The update includes metabolomic, genetic, and imaging data, plus much more, all alongside our existing comprehensive dataset

Explore what's new: www.ukbiobank.ac.uk/news/metabol...

Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing Population-scale whole-genome sequencing data will contain many individual-level genotype errors, even after allele-level quality control (QC). We establish the need for genotype-level QC using UK Bio...

New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data

www.biorxiv.org/content/10.1...

Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”

Looking to reduce control sample sizes in population-based studies? We recommend case–control matching GWAS as an efficient and cost-effective strategy for rapid association testing across multiple phenotypes.

Prostate cancer risk-stratification using proteomic estimation of KLK3 improves accuracy in screening applications: a population-based cohort study in the UK Biobank www.medrxiv.org/content/10.1101/2025.08....

Thanks a lot☺️will motivate me to do more work

James, thank u so much☺️🍻

Glad to receive this award, many thanks to my awesome supervisor @harrygreentkd.bsky.social and amazing Cancer Genomics, GOCT and DISCO team @exeter.ac.uk, more work will do on ProtecT study, hope to see the GRS/PRS🧬 can helpful to distinguish more aggressive PCa

11:30 Tuesday @Space1+2, come and join my talk with C34.03- combining the GRS/PRS🧬 and PSA🩸test results together to predict the prostate cancer #eshg2025

Catch your last minute tickets here !!!
pintofscience.co.uk/events/exeter

Harry reflects on his time at the CaPRI conference: The Cancer in Primary Care Research International (Ca-PRI) conference. Author: Dr Harry Green, Lecturer in Health Data Sciencehttps://tinyurl.com/4hymyk2m @apexcomms.bsky.social, @hls.exeter.ac.uk, @uniofexeternews.bsky.social,@nihrspcr.bsky.social

… and that’s wrap from us @apexcomms.bsky.social at #CaPRI2025

Fantastic 2 days of showcasing @exeter.ac.uk Primary care #cancer work, exchanging ideas and getting ready for more !

#TeamExeter
@richarddneal.bsky.social @ssarahbailey.bsky.social @tani-03.bsky.social

Predicting #prostateCancer by combining #PSA test results with #genetic risk scores.

Impressive presentation by Jingzhan Lu at #CaPRI2025

@apexcomms.bsky.social @sammerriel.bsky.social @richarddneal.bsky.social