The first re-flight of Blue Origin's New Glenn included another successful booster recovery. However, we never got any updates after the second stage reached orbit, until we were informed the payload was deployed into an off nominal orbit. AST Space Mobile's satellite may be lost.
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
We have some fresh and cool #glycotime 🧪 on the impact of including glycosylation explicitly in de novo binder design. Filtering the results of a recent open competition for novel binders to the Nipah Virus Glycoptrotein (NiV-G) with ReGlyco improves the pipeline efficiency significantly ⬇️
Rods have a continuous multilamellar architecture - unlike any known cellular membrane organisation - and occur across all cell types tested /3
🙏 @andimicroscopy.bsky.social
We show that - in mammalian cells and in vivo -
saturated lipids in the #endoplasmic reticulum can demix into stable, micrometer-scale #solid-like domains.
The resulting long-range orientational order in the membrane gives rise to cell-spanning, rigid tubular structures, we term #rods /2
As American's file taxes on #TaxDay, I am one of those who benefits. #NIH has funded our lab's discovery based research for 34 years. We contributed to understanding how cells chose fate & shape tissues and organs, & work in our field gave insights into colorectal cancer and cancer metastasis 1/n
In an unexpected turnaround, the US NSF has handed out a record 2,599 of its prestigious graduate fellowships to young researchers — after slashing the number to a low of just 1,000 last year
go.nature.com/48loNI3
We are thrilled to announce the newest class of Damon Runyon Fellows, 13 exceptional early-career scientists who are working to push boundaries and make breakthroughs in cancer research. Read more about their projects: https://bit.ly/4muFTsP
Thank you #NobelLaureate Jack Szostak for sharing these thoughts, which many US scientists and physicians resonate with
newsletter.ofthebrave.org/p/im-a-nobel...
Home of the Brave exists to show Americans the real-world consequences of this administration’s policies, and to highlight what bravery looks like in defense of American democracy. Hoping more scientists who have megaphones are brave enough to use it. Thank you Jack for using yours.
"All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."
open.substack.com/pub/ofthebra...
Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI
On March 24, clinically focused Damon Runyon scientists and industry partners gathered at Amgen in Cambridge, MA for the 2026 Accelerating Cancer Cures Symposium. The symposium aims to foster conversation and spark collaboration between academia and industry. Read more: https://bit.ly/47XXWkQ
A little late to Bluesky but my postdoc work w/ @jbuenrostro.bsky.social now out in @nature.com
"Epigenetic memory of colitis promotes tumour growth"
www.nature.com/articles/s41...
We wanted to understand how transient inflammation can create an increase in cancer risk, even after full recovery 🧵
850 Tomahawk missiles could be $3,060,000,000... That is 3 billion sixty million US dollars.
That is 1224 5 year biomedical research grants. Literally, over 6 millennia of biomedical research.
We found a new brain shuttle! Mucins on brain endothelium mediate transcytosis of cargo linked to mucin-binding “C domain”. Congratulations Sophia Shi, now a Roland Fellow @harvard.edu, and longtime collaborator Tony Wyss-Coray @stanfordmedicine.bsky.social
www.biorxiv.org/content/10.6...
🧲
Excited to see our MagMix platform on the cover of Device! MagMix is a modular, compact, material-agnostic in situ mixing platform for 3D bioprinters that actively + safely homogenizes cell-laden bioinks with no printer hardware/software mods:
www.cell.com/device/fullt...
@cellpress.bsky.social
New preprint to share! Incredible collab w/ Fei Chen’s lab: developed in vivo CRISPR screening platform for 🫁 epithelium, allowing single cell perturbation in post-flu repair. Take a peek to see what we found! Huge congrats to the leaders of this work @daisyah.bsky.social & @sundakao.bsky.social 🎉
The US-Israel war on Iran has emitted 5 million tonnes of CO₂ₑ in its first 14 days. The world currently has 0.6 million tonnes of novel and permanent CO₂ removal (CDR) capacity annually.
A nature-inspired ion trap for parallel manipulation of ions on a massive scale | Science Advances www.science.org/doi/10.1126/.... Very nice work by Brian Chait and Andrew Krutchinsky from @rockefeller.edu inspired by parallel sequencing in genomics and other technologies. Congratulations
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...
The big reveal… so proud of Sonika Kohli and Angel Bu for winning a Koch Institute Image Award for their piece titled “Repairing Lost Connections” featuring our lab’s work on treating nerve injuries. Check it out for yourself by visiting the public galleries at the MIT Koch Institute!
Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing.
tinyurl.com/32pf6b8p
This is why we love #CalciumSignaling
Look how mechanical damage triggers long range Ca2+ waves in this plant !!
By @annalisabellandi.bsky.social, who is now around here ;)
Full www.science.org/doi/10.1126/... @science.org #microscopy #cell #mechanobiology 🧪🔬
The vast majority of labs in the U.S. rely on federal funding to do their research - labs like my own.
We're already running on fumes and while top-line budgets have been maintained, for now, research isn't getting funded.
Once those fumes are out 👉 🪦.
elizabethginexi.substack.com/p/i-wrote-re...
We made the front cover of Advanced Science with our paper on using tendons to make muscle-powered robots stronger! Happy to be part of an exciting special issue on "Sustainable Materials in Soft Robotics and Electronics". Check out our paper here:
doi.org/10.1002/advs...
#biofabrication #robotics
Kathrin @katleppek.bsky.social and Ina @inahuppertz.bsky.social cordially invite all RNA enthusiasts based in the Rhineland to attend our series of inspiring in-person talks on RNA-related topics, delivered by local and invited speakers.
A new mechanism for “RNA memory”! This time in Planaria! (Here's a video of a Planarian with mulitple heads, one of the heritable phenotypes we studied).
This work summarizes >10 years of research and is an amazing collaboration with the labs of Jochen Rink and Omri Wurtzel labs. Read thrad below👇
