(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO).

Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply

sites.wustl.edu/millmanlab/

Using advanced microscopy and multi-omics approaches, we identify histone methyltransferase EZH2, along with key chromatin remodelers, as central regulators of MSC phenotypic drift during expansion.

Mechanoepigenetic Targeting of Histone Methyltransferase EZH2 Increases Potential of Scalable Manufacturing in Human Derived Primary Mesenchymal Stromal Cells Manufacturing clinical grade mesenchymal stromal cells (MSCs) remains a major bottleneck for cell-based therapies, as extensive in-vitro expansion on standard tissue-culture plastic (TCP) drives loss ...

New preprint from our lab! We investigated how MSCs lose potency during serial passaging - a critical bottleneck in MSC manufacturing, and how epigenetic interventions can help preserve their quality at the therapeutic endpoint. www.biorxiv.org/content/10.6...

Turns out, epigenetic regulation plays a central role in how cells respond to oxidative stress having implications for regenerative medicine and aging research.
Have a look! Executed by a team of PhD, MS and undergraduate students in our lab.#stemcells #epigenetics #chromatin #regenerativemedicine

What we found: ROS triggers striking chromatin compaction and remodeling — but pretreatment with a selective EZH2 inhibitor (GSK126) alters this response, preserving chromatin accessibility and reducing DNA damage.

This can occur at critical moments — like after therapeutic expansion and delivery to injury sites, or during inflammation in native tissues. To explore this, we combined high-resolution live-cell imaging with ATAC-seq to track real-time changes in chromatin architecture.

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and fo....

This is my first Bluesky post to a very limited connection. New paper published from our lab and it is open access! What happens to the chromatin structure of mesenchymal stem/stromal cells when they’re exposed to high levels of reactive oxygen species (ROS)?
doi.org/10.1002/adbi...