Super proud PI 🤩 Listen to Tatiana's findings about synaptic proteomic changes in AD progression!

at least you learnt not to do it again...hope I remember this for next year!

the number of deadlines I have for the first 10 days of January is incredible...grant reviews, grant rebuttals, reference requests, marking...anyone would think that academics don't need a winter break...sigh

Thank you so much, was great to hear about your journey and to see you interviewing the others!

A great week at #AAIC25. Thanks to @alzheimerssoc.bsky.social and @alzassociation.bsky.social for the opportunity!

Was fun...and hot 🥵

Come and hear about how the synaptic protein, SV2a, is not always found at synapses. To find out where else it is, come and see our group's poster #384 today. #AAIC25

Poster today #161

#AAIC25 Come and hear about synaptic proteomic changes over disease progression presented by the amazing Tatiana Georgiades in work funded by @alzheimerssoc.bsky.social

Sometimes I can't find it anywhere in the paper!

This! Looking at my summer of deadlines whilst juggling childcare...😭

A compilation of reported alterations in the cerebrospinal fluid proteome in Alzheimer's disease de Geus et al. report that a compilation of CSF proteomics studies in Alzheimer’s disease identified 61 consistently altered proteins across mass spectrome

We have a new paper alert🎉

This work compiles all reported protein changes in the cerebrospinal fluid of Alzheimer’s patients across studies using mass spectrometry, Olink, and SomaScan platforms.

Check it out here:
academic.oup.com/braincomms/a...

#Alzheimers

I feel seen 👀

Super proud of my PhD student, Tatiana, for being chosen as an @istaart.bsky.social Ambassador!

really looking forward to speaking in this session!

Thought this for a while...they kill the vibe

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

@imperialcollegeldn.bsky.social is looking for a new Head of Brain Sciences. Please repost and/or consider applying!!

www.imperial.ac.uk/jobs/search-...

I've added you to the synapse starter pack...welcome!

Congratulations to my first Imperial PhD student Eleonore Schneegans! It's been a pleasure supervising you with Nurun Fancy and Paul Matthews. And thanks to the amazing examiners @sj-marzi.bsky.social and @ppetra.bsky.social. Pretty much an all woman dream team 😍

very cool, congrats!

Would be happy to help review

I seem to do all major work and life events together too...or maybe that's just adulting

Thanks for being such an awesome colleague! We will miss you but exciting times ahead for you!

PhD: Role of LRRK2 in cellular senescence in Parkinson’s Disease Dr Nurun Fancy at Imperial College London is seeking a PhD Student to explore the role of LRRK2 in cellular senescence in Parkinson's Disease

Dr Nurun Fancy at Imperial College London @imperialcollegeldn.bsky.social is seeking a PhD Student to explore the role of LRRK2 in cellular senescence in Parkinson's Disease. Closing date: 15th March #PhDPosition

www.dementiaresearcher.nihr.ac.uk/job/phd-role...

I don’t think many of my American scientist friends will leave the US despite the recent political changes affecting the NIH.

But if they were interested, they should apply to become centre director here in Cardiff!

www.ukdri.ac.uk/vacancies/ce...

This opens up new synaptic tragets and avenues for the therapeutic targeting of synapses in AD. This was a great team effort by Jessica Griffiths joint with Seth Grant lab, Eleonore Scheegans and the UKDRI MAP team. The end. 6/6

Taken together, we believe we have derived a pseudotemporal profile of synaptic changes in human AD and shown that they are associated with changes in the astrocyte proteome, particularly that of PAPs. 5/6

Alongside these synaptic changes, we found a astrcoyte signature that was enriched for proteins at the peri-synaptic astrocytic processes (PAPs). This astrocyte signature increased with pathology and was associated with reduced synaptic resilience. 4/6

Mitochondrial proteomic changes dominated in the low pathology region, inhibitory changes in the mid pathology region and widespread synaptic transmission pathways were most prominant in the higher pathology region. 3/6

We showed that there are synaptic proteomic changes in a region of low pathology before synapse loss and that synapse loss and proteomic changes increased in regions with higher pathology. 2/6