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PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells - Cell Death Discovery Cell Death Discovery - PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells

New PAPER alert! Led by Yano, our latest study presents how PARPi-induced heterochromatin boosts replication stress and ATRi sensitivity, revealing a new strategy for targeting SMARCA4-deficient tumors.
Link: www.nature.com/articles/s41...