Finished My Hero Academia.... Damn man hopecore to the max. Go Beyond Plus Ultra baby!!!

Annulative Skeletal Diversification of Pyrimidines to Expanded Heteroaromatic Space Single-atom skeletal editing has recently emerged as a powerful strategy for the direct diversification of the heterocyclic cores of various compounds. Yet, methods that enable monocycle-to-bicycle transformations that involve core atom changes remain scarce. Herein, we report a two-step, one-pot protocol that converts pyrimidines into 7-azaindazoles and pyrazolo[1,5-a]pyrimidines, two privileged scaffolds in medicinal chemistry. Fine-tuning the reaction parameters enables chemodivergent control, allowing selective access to either framework, with the pyrimidine scope including pharmaceutical drug molecules. Moreover, the strategy has been extended to afford differently substituted pyrimidines, partially saturated fused skeletons, and quinoline derivatives. Access to this broad, expanded, heteroaromatic space underscores the potential for heterocyclic diversification using this approach.

pubs.acs.org/doi/10.1021/...

New Dadphos out today in JACS. V cool @bagphos.bsky.social

It's ok to give into them occasionally. Something about those tater tots especially just got different

Yo straight up, the free breakfast with all the healthy options and the discounted lunches with also healthy options! It's helped me lose a ton of weight!!!

Thank you!!

Party! 🤠🤠

Thanks!! Very hyped!

Ty!! I think I will!

Thank you!!! Still in the northeast!!!! So easy to come hang!!!

Thanks fam! We out here!!!

Ty ty 😭😍

Ty!!!

Thank you!!!! Boston baby! Staying in the bean town a bit longer!

Ty chem papi 😭😭😭

THE BENEFITS CJ!!! SO GOOD

Rewiring amino acids to piperidines - Nature Catalysis Bioactive piperidines are among the most common motifs in pharmaceuticals, yet accessing their chiral, highly substituted forms remains challenging. Now, a copper-catalysed reaction of amino-acid-deri...

www.nature.com/articles/s41...

COOL LIT ALERT

(thanks @ndchiappini.bsky.social for the heads up)

Offer signed. New Title: Process Chemistry Scale-Up Scientist, Vertex Pharmaceuticals 🫡

100000%

Vibes are immaculate today.

MFW finding a pyridine nomenclature mistake in this paper

Oh yeah absolutely!! I have a Steamdeck so I would also probs play that too!!

a screenshot of a video game that says load game on it ALT: a screenshot of a video game that says load game on it

We're moving and I'm gonna be taking a nice train to work from now on....

Its gonna be just like Persona 5 omg

a cartoon drawing of a man with green hair and a backpack on his back ALT: a cartoon drawing of a man with green hair and a backpack on his back

Critical Role Campaign 2 will always be my favorite b/c you get to watch Travis Willingham and Laura Bailey fall in love all over again 😭😭😭😭😭😭😭😭😭😭

Swan Songs by Hollywood Undead might be a perfect album.

"Who are we angry at?"

"The haters"

"Who exactly are 'the haters'"

"Idk the people who hate!!"

a football player with the number 88 on his jersey is kneeling down on the field ALT: a football player with the number 88 on his jersey is kneeling down on the field

FOUND A WAY TO PURGE IMPURITY BELOW SET SPECS. SLIME ME UP CUH LFG!!!

a cup of oreos sits next to a bottle of tropicana orange juice ALT: a cup of oreos sits next to a bottle of tropicana orange juice

Me: hey isolated side product can I spike you into my reaction and see if you're the cause of this impurity I'm seeing??

Isolated Side Product: best I can do is turn your reaction orange with zero impact on impurity formation...

LETS GO!

Just like @bagphos.bsky.social ! He's a big ol cutie pie

I will keep trying 🫡

Oxygen migration into carbon–carbon single bonds by photochemical oxidation - Nature Synthesis Heteroatom insertions into chemically inert carbon–carbon single bonds are rare compared to their unsaturated analogues. Now, ligand-to-metal charge transfer offers a promising entry point for oxygen ...

www.nature.com/articles/s44...

Ok but @bagphos.bsky.social still doesn't have a JACS 🙄

(this is a joke post and should not be taken seriously, I'm super excited for Dadphos and his work!!!)