A must-read, landmark paper by @lisaschweizer.bsky.social
- hands down one of the most accomplished scientists I know. Congratulations👏 @mannlab.bsky.social @lengyel-ovca-lab.bsky.social
bsky.app/profile/mann...

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Prot...

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...

Since April, @tnordmann.bsky.social has been leading a research Group @mpibiochem.bsky.social. He has now been awarded the prestigious Oscar Gans Prize by the German Dermatological Society. Congratulations and welcome!

#award #dermatology #proteomics @mannlab.bsky.social

Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial - Nature Medicine In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients surviving over 40 months from diagnosis.

In patients with diffuse intrinsic pontine glioma, a rare, fast-growing and fatal pediatric brain tumor, local delivery of B7-H3 targeting CAR T cells was feasible and well tolerated with a median overall survival of 19.8 months, according to a trial reported in Nature Medicine. #MedSky 🧪

Our mipDVP workflow integrates 22-marker imaging with Deep Visual Proteomics to spatially map cell-type proteomes in hot/cold tumors, revealing distinct immune landscapes, macrophage barriers, T cell adaptations to hypoxia & tumor heterogeneity. Online in Molecular Cell.
doi.org/10.1016/j.mo...

My favorite books, 2024

Why not do some proteomic analysis and dig deeper on the role of HHV6 in pityriasis rosea 🔬 Such a fascinating rash and so poorly understood.

Looking forward to a fabulous 2025, full of happiness and scientific achievements! 🔬💫

Spatial omic technologies will shape the way we practice medicine in the future. Follow me on bluesky, there is so much more to come 🎻

A new understanding of tissue biology from MS-based proteomics at single-cell resolution - Nature Methods Spatial mass spectrometry (MS)-proteomics is a rapidly evolving technology, particularly in the form of Deep Visual Proteomics (DVP), which allows the study of single cells directly in their native en...

Spatial proteomics is Method of the Year 2024 @naturemethods.bsky.social!🎉🤩 Grateful to share our perspective on spatial proteomics with the great Matthias Mann and Andreas Mund, alongside inspiring colleagues shaping this exciting field - this is just the beginning 💫
www.nature.com/articles/s41...

www.nature.com/articles/s41...
Commentary by @tnordmann.bsky.social
Editorial @naturemethods.bsky.social www.nature.com/articles/s41...

A new understanding of tissue biology from MS-based proteomics at single-cell resolution - Nature Methods Spatial mass spectrometry (MS)-proteomics is a rapidly evolving technology, particularly in the form of Deep Visual Proteomics (DVP), which allows the study of single cells directly in their native en...

Spatial proteomics is Method of the Year 2024 @naturemethods.bsky.social!🎉🤩 Grateful to share our perspective on spatial proteomics with the great Matthias Mann and Andreas Mund, alongside inspiring colleagues shaping this exciting field - this is just the beginning 💫
www.nature.com/articles/s41...

After long-time review, #nanoSPLITS is finally published. I am deeply grateful to my colleagues who made this work possible, especially @cajunscience.bsky.social. I am also grateful to the support of our single-cell proteomics community during the peer review on Nature Communication!

A bench-to-bedside targeted therapy story!

Fatal disease ➡️ patient samples ➡️ deep proteomics ➡️ find target (jak/stat) ➡️ realize drugs exist ➡️ try drugs in lab ➡️ it works! ➡️ give drugs to patients ➡️ holy cow it actually works!!!! ➡️ save lives.

This is the dream. Nice work @tnordmann.bsky.social

Thank you for your support @nizet.bsky.social. Bench-to-bedside is the ultimate goal of my research and we are so proud to have contributed to the field of severe cutaneous drug reactions.

Wow—one of the most impressive bench-to-bedside stories you’re ever going to see out today @Nature

Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy!

www.nature.com/articles/s41...

Thank you @marie-will.bsky.social. It has been an amazing journey and truly a dream come true!

Science twitter is dead! Long live science twitter! 🦋

First BlueSky post :)

The Dawn of Spatial Medicine For the first time spatial omics leads to a lifesaving treatment

The Dawn of Spatial Medicine
Until now, spatial omics was used to understand human biology. That changed when it saved lives of patients with a fatal skin condition.
In the new Ground Truths
erictopol.substack.com/p/the-dawn-o...