Comparison of the Trapping Efficiency for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses | MDPI www.mdpi.com/2227-73...

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#proteomics #prot-paper

The Proteomics Show is back! Check out chapter one of "All the Parts!"   In this US HUPO sponsored season (thank you!) we're being serious scientists who are asking the big questions of bigtime experts of specif...

News in Proteomics Research blog post | The Proteomics Show is back! Check out chapter one of "All the Parts!" proteomicsnews.blogs...

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#proteomics #prot-other

A Native Nepenthesin Reactor for Improved Proteolytic Digestion of Intrinsically Disordered Proteins in Proteomics Workflows A workflow is presented for the extraction and purification of native nepenthesin (NEP-NAT) from Nepenthes species, followed by the enzyme's immobilization on POROS-AL chromatographic material. The N...

Latest publication from SNP2Prot colleagues C. Wall and A. Sinz reveals that the Nepenthesin protease, isolated from 𝘕𝘦𝘱𝘦𝘯𝘵𝘩𝘦𝘴 sp., carries superior proteolytic activity towards IDPs.

Kudos to the team 🎉

doi.org/10.1002/cbic...

#MassSpec #Protease #IDPs
#Proteomics

@sinzandrea.bsky.social

TUM - Doctoral Candidate f/m/d in computational proteomics/bioinformatics portal.mytum.de/jobs...

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#proteomics #prot-jobs

Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative rigor with the discovery capabilities of accurate mass systems. Here we present the ZenoTOF 8600 system, a compact mass spectrometry system that integrates enhanced ion capture and transmission optics with an optical detection system, Zeno trap-enhanced MS/MS, electron-activated dissociation, and scanning quadrupole data-independent acquisition (ZT Scan DIA). We show that ZT Scan DIA outperforms conventional variable-window DIA (Zeno SWATH DIA) in both identifications and quantitative reproducibility, and demonstrate the platform’s versatility across proteomics applications: thousands of protein groups from bulk samples at up to 500 samples per day, single-cell proteomics yielding up to 4,700 proteins, accurate ratio recovery in mixed-species quantitative benchmarks, low-attomole targeted quantitation, and detection of disease-relevant phosphorylation in a Parkinson’s disease cellular model using complementary CID and EAD fragmentation. The instrument’s compact footprint makes it attractive for settings where both analytical breadth and operational robustness are required.

Why choose between sensitivity and discovery?

ZenoTOF 8600 system = triple quad–class sensitivity + accurate mass QTOF.

One platform. No compromises. 🔥

Learn more: buff.ly/tvralVM

#proteomics #QTOF

Oben: Grafik: Die Peptidiscs (blau) markieren die Membranproteine für die affinitätsbasierte Aufreinigung. Unten: Die Überschrift des im Post verlinkten Artikels "Heile Membranproteine mit Peptergent“, gefolgt von dessen Vorspann „Intakte Proteine aus Membranen herauszupulen, ist eine Kunst. Die Chancen steigen, schützt man die Proteine während der Extraktion mit einem Peptid-Mäntelchen.“ Links daneben befindet sich ein Icon mit Smartphone und Magazinseite sowie der Schriftzug „Kostenlos online lesen!“. In der rechten unteren Ecke befindet sich das Laborjournal-Logo.

Ausschnitt aus dem verlinkten Artikel.

#Membranproteine - Kanadische Forscher entwickeln eine innovative #Methode der Isolation: Sie kombinieren #Peptergents – Peptid-Mäntel, die Membranproteine stabilisieren – mit His-getaggten #Peptidiscs. Mehr im Artikel von Andrea Pitzschke: www.laborjournal.de/editorials/3...
#LifeSci #Proteomics

Enhancing survival risk prediction through imputation and feature selection in high-dimensional protein biomarker data www.nature.com/artic...

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#proteomics #prot-paper

Wavelet Transform for Frequency‐Division Multiplex Mass Spectrometry Combined With High‐Performance Liquid Chromatography analyticalsciencejou...

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#proteomics #prot-paper

A Multiplexed Quantitative Analysis of Germline Single Amino Acid Variants by Targeted Proteomics in Nondepleted Human Plasma pubs.acs.org/doi/10....

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#proteomics #prot-paper

Senior Scientist (Analytical and Biological Mass Spectrometry) - New York, USA, Tarrytown www.pharmiweb.jobs/j...



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#proteomics #prot-jobs

Investigating the Efficiency of Ultraviolet Photodissociation in Peptides Modified with N-Terminal UV-Absorbing Chromophores pubs.acs.org/doi/10....

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#proteomics #prot-paper

What Does Next-Generation Mass Spectrometry Offer for Proteomics? A Comprehensive Platform Comparison pubs.acs.org/doi/10....

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#proteomics #prot-paper

CombinGym: a benchmark platform for machine learning-assisted design of combinatorial protein variants www.biorxiv.org/cont...

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#proteomics #prot-preprint

News in Proteomics Research blog post | How do commercial procedures impact the blood plasma proteome! proteomicsnews.blogs...

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#proteomics #prot-other

KTH Spinout ProteomEdge Offering Absolute Quantitation of Plasma Proteins www.genomeweb.com/pr...

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#proteomics #prot-article

Mascot search engine | Protein identification software for mass spec data Mascot software from Matrix Science - identification, characterisation and quantitation of proteins using mass spectrometry data

matrixscience.com is being overwhelmed by millions of HTTP requests from distributed botnets, essentially a distributed denial of service (DDoS) attack. We are forced to mitigate it by restrict access to certain pages of dynamic content.

www.matrixscience.com/whats_new/mi...

#proteomics #massspec

News in Proteomics Research blog post | Non-reducing proteomics opens up a whole new pile of PTMs under stress! proteomicsnews.blogs...

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#proteomics #prot-other

Impact of Variations in Commercial Standard Operating Procedure on Plasma Proteome Recovery pubs.acs.org/doi/10....

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#proteomics #prot-paper

Turning up the throughput in mass spectrometry - 2026 - Wiley Analytical Science analyticalscience.wi...

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#proteomics #prot-paper

Vibe Coding Comes to Omics How Jesse Meyer built a fully functional proteomics data analysis application in under 10 minutes, using four prompts, no handwritten code, and under $2

Vibe Coding Comes to Omics - How @j-my-sci.bsky.social from @cedarssinaihsu.bsky.social built a #proteomics data analysis application in under 10 minutes, using four prompts, no handwritten code, & under $2 www.theanalyticalscientist.com/issues/2026/... #coding #vibecoding #bioinformatics

🧬 Neue Veröffentlichung: KI in der Proteomik!
Unser Review zeigt, wie KI die Vorhersage der Peptid-Detektierbarkeit verbessert – Grundlage für bessere Biomarker & Diagnostik.

Analyse (25 Studien): Bedarf an Standards, Transparenz & offenen Daten.
doi.org/10.34133/csb...

#AI #Proteomics

ProtAIomics

📢 PhD position re opened in the ProtAIomics MSCA Doctoral Network. Hosted by Petr Novác, the project focuses on structural characterization of proteins and protein complexes
👉 apply here www.protaiomics.eu.
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities

Recent Developments and Applications of Capillary and Microchip Electrophoresis in Proteomics and Peptidomics (2023–2025) analyticalsciencejou...

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#proteomics #prot-paper

Remember, once in a Blue Moon, to visit Pastel BioScience's resource pages ...

https://t.ly/EP3hr to see updated list of new #proteomics software packages (153) in 2025 &,

https://t.ly/Mlk39 for Conferences/Symposia/Webinars etc (11) already available in 2026

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#proteomics #prot-other

A high-affinity split-HaloTag for live-cell protein labeling www.nature.com/artic...

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#proteomics #prot-paper

Integrated intraocular–plasma proteomics reveals conserved biomarkers for diabetic retinopathy progression: a multi-fluid biopsy study - Diabetologia Aims/hypothesis The aim of this study was to identify conserved biomarkers for diabetic retinopathy progression, addressing the lack of minimally invasive biomarkers to track the entire continuum of d...

A multi-fluid biopsy study shows that plasma neurofilament light chain (NFL) tracks diabetic retinopathy severity and is associated with future diabetic microvascular and macrovascular complications. #DiabeticRetinopathy #Proteomics link.springer.com/article/10.1...

Vacature — PhD student in mass spectrometry of aggregating proteins werkenbij.vu.nl/vaca...

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#proteomics #prot-jobs

GlycoDiveR: a modular R framework to analyze and visualize highly dimensional glycoproteomics data www.biorxiv.org/cont...
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#proteomics #prot-preprint

Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neurons - Molecular Neurodegeneration Advances Background Understanding synapse-specific effects of neuroinflammation can provide mechanistic and therapeutically relevant insights across the spectrum of neurological diseases. Methods We applied ne...

#Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and #mitochondria in excitatory neurons

Claudia Espinosa-Garcia, Upasna Srivastava, Prateek Kumar...Srikant Rangaraju #proteomics #AlzheimersDisease

link.springer.com/article/10.1...

WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome academic.oup.com/g3j...

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#proteomics #prot-paper