Visualizing the sarcomere’s molecular architecture in its native state is crucial to understanding the structural changes behind cardiomyopathies. Join the Raunser Lab @raunser-lab.bsky.social @imprs-lm.bsky.social to explore heart cells in unprecedented detail using #cryo-electrontomography.

Great thread, Thorsten. You are our hero! You have done so much for our group - always with humor, always with fun, always eager to learn and curious: “the ones who spread love, get love back.”

💪 NEW VIDEO:
Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work.

Rendered using @bradyajohnston.bsky.social 's molecular nodes

Model based on the incredible work of the @raunser-lab.bsky.social lab

Really cool!!!

How bacterial Tc toxins work: secretion, pore formation and host cell disruption. YouTube video by Max Planck Institute of Molecular Physiology

Our new movie is online, highlighting the assembly, secretion and mechanism of action of bacterial Tc toxins. We hope you enjoy it and use it for teaching purposes or just for fun. Nature is fascinating!

www.youtube.com/watch?v=UfEf...

Multistate kinetics of the syringe-like injection mechanism of Tc toxins Tc toxins perforate cells via a multistep process involving three intermediates, modulated by lipids, receptors, and pH.

First paper 2025🎇
Multistate kinetics of the syringe-like injection mechanism of Tc toxins - published by Enrica Bordignon & @raunser-lab.bsky.social in @science.org Advances #CryoEM

www.science.org/doi/10.1126/...

Muscles growth by sarcomere divisions - how your muscles add new sarcomeres during developmental growth: they divide! Cool collaboration @friedrich-group.bsky.social @raunser-lab.bsky.social @Dirk Görlich @univ-amu.fr @cnrs.bsky.social sciencecast.org/casts/aspy9l... www.biorxiv.org/content/10.1...

Let's start here with some good news!
The @raunser-lab.bsky.social is one of the first 2 labs in the @maxplanck.bsky.social to be certified by my green lab! The lab team included a couple of sustainable best practices, like changing/reducing consumables, saving liquid nitrogen... #LabSustainability

Here is our preprint on the multi-state kinetics of the syringe-like injection mechanism of Tc toxins. Great collaboration between our lab @mpi-dortmund.bsky.social, the Seidel lab @hhu.bsky.social, the Bordignon lab - University of Geneva and the Dong lab - Harvard.
biorxiv.org/content/10.1...

Let's start 2024 on Bluesky although the weather outside makes us believe that there are only grey rainclouds.