Chromatin accessibility landscape of mouse early embryos revealed by single-cell NanoATAC-seq2 In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell r...

Finally! Single cell ATAC seq

www.science.org/doi/10.1126/...

x.com/gonen_nitzan...

Who was Rita Levi-Montalcini? - the Node Rita-Levi Montalcini (1909-2012) was an Italian neurobiologist who lived an extraordinary life, and today (22nd April) would have been her 115th birthday.

Alex Neaverson, one of #theNodeCorrespondents, created an illustrated post about the inspiring life of Rita-Levi Montalcini, who overcame many barriers in her personal and scientific life:

thenode.biologists.com/who-was-rita...

(3/3) #WomeninScience #IDWGS

Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe - PubMed Olfactory receptor (OR) gene choice, the stable expression of one out of >2000 OR alleles by olfactory sensory neurons, constitutes a gene regulatory process that is driven by three-dimensional nuclea...

An excellent review on gene regulatory process that is driven by three-dimensional nuclear architecture.
pubmed.ncbi.nlm.nih.gov/40107115/

3rd Crick Beddington Symposium: Anterior Fates Await Those Who Migrate - How Nodal Dynamics Shape Anteroposterior Patterning - the Node Although I originally set out to highlight the work of early career researchers at the symposium, Professor Vasso Episkopou’s overwhelmingly enthusiastic

Anterior Fates Await Those Who Migrate – How Nodal Dynamics Shape Anteroposterior Patterning

Alex Neaverson, one of #theNodeCorrespondents, spoke to @vepiskop.bsky.social at the 3rd Crick Beddington Symposium, to find out more about her research:

thenode.biologists.com/3rd-crick-be...

Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.

www.nature.com/articles/s41...

Sounds like a plan

Could the mini moon become another state of the USA?
Earth’s recent ‘mini-moon’ may be an actual piece of the moon, astronomers say

Can herpies virus exacerbate or even trigger neurodegenerative disease?

www.cell.com/cell-reports...

New year! New social media! And new job opening!! Join us on a programme leader track to start your group @mrc-lms.bsky.social! Supportive colleagues, wonderful new building and outstanding facilities! #cellidentity #sexdifferences #genesenvironment

Bizarre bacteria defy textbooks by writing new genes Bacterial defensive systems scramble the standard workflow of life.

Just in case you missed this last year!
www.nature.com/articles/d41...

‘LIfe-Changing’ Psychedelic, for When Life Is Ending People are turning to psilocybin, ketamine and other treatments for palliative care.

www.nytimes.com/2024/12/17/h...

Special Issue: The development and use of pluripotent stem cells: An historical perspective: BioEssays: Vol 46, No 12 BioEssays is a review-and-discussion journal renowned for its collection of contemporary and forward-looking reviews on molecular, genetic and cellular biology.

For all mankind
onlinelibrary.wiley.com/toc/15211878...

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/