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Posts by Allergy EAACI

Ardicli et al. investigate the effects of the widely used polyethylene terephthalate polymer, known as #PET, which is commonly used for water and beverage bottles and packaged foods, on human intestinal cell cultures at various concentrations and particle size range. At high doses, transepithelial electrical resistance measurements and the MTT cell viability assay indicate epithelial barrier dysfunction and oxidative stress, respectively. Transcriptomic analysis supported the dose-dependent physiological and proteomic changes. Upregulated genes corresponded to pathways related to apoptosis, endoplasmic reticulum stress and oxidative stress responses. These findings highlight the toxic effects of micro and nanoplastic ingestion on human health.

Ardicli et al. investigate the effects of the widely used polyethylene terephthalate polymer, known as #PET, which is commonly used for water and beverage bottles and packaged foods, on human intestinal cell cultures at various concentrations and particle size range. At high doses, transepithelial electrical resistance measurements and the MTT cell viability assay indicate epithelial barrier dysfunction and oxidative stress, respectively. Transcriptomic analysis supported the dose-dependent physiological and proteomic changes. Upregulated genes corresponded to pathways related to apoptosis, endoplasmic reticulum stress and oxidative stress responses. These findings highlight the toxic effects of micro and nanoplastic ingestion on human health.

Open Access: Polyethylene Terephthalate Micro and Nanoplastics Induce Oxidative and Endoplasmic Reticulum Stress, Compromising Intestinal Epithelial Integrity and Viability. First author: Sena Ardicli; corresponding author: Cezmi A. Akdis

👉 doi.org/10.1111/all.70291

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Schnitzler syndrome as an autoinflammatory disease driven by B-cell-specific somatic MYD88 mutation
Schnitzler syndrome as an autoinflammatory disease driven by B-cell-specific somatic MYD88 mutation YouTube video by Allergy

Y.Zhou, Y.Ueki, N.Iwata, et al., “Schnitzler Syndrome as an Autoinflammatory Disease Driven by B-Cell-Specific Somatic MYD88 Mutation,” 👉 doi.org/10.1111/all.70338

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There has been a resurgence of respiratory viruses after the post-COVID pandemic. With over 300 references and five figures, this review article explores risk factors associated with this recent global rise in acute respiratory infections.

There has been a resurgence of respiratory viruses after the post-COVID pandemic. With over 300 references and five figures, this review article explores risk factors associated with this recent global rise in acute respiratory infections.

Risk and Protective Factors for Infection, Severe Disease, and Mortality in Epidemic Respiratory Viruses. Corresponding authors: Ya-dong Gao, Cezmi A. Akdis

👉 doi.org/10.1111/all.70314

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Read more articles published in #Allergy on #COVID-19 here: journalallergy.com/COVID-19

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Join the global allergy and clinical immunology community for: 🔬 Cutting-edge science & clinical advances 🤝 Meaningful connections with international experts 💡 A dynamic space for collaboration and innovation

Join the global allergy and clinical immunology community for: 🔬 Cutting-edge science & clinical advances 🤝 Meaningful connections with international experts 💡 A dynamic space for collaboration and innovation

✨ Theme: Vision Zero: A Future Free from Allergy and Asthma Burden
📍 12–15 June 2026 | Istanbul, Türkiye

👉 Register now & explore the programme: eaaci.org/events_congress/eaaci-congress-2026/registration/registration/

#EAACI2026 #Allergy #Asthma #ClinicalImmunology

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This is a retrospective study of the adverse reactions from 145 patients treated with #biologics and/or Janus kinase (JAK) inhibitors (JAKi) or immunosuppressants. The authors postulate immune mechanisms to explain the observed adverse effects. Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease #Allergy_journal

This is a retrospective study of the adverse reactions from 145 patients treated with #biologics and/or Janus kinase (JAK) inhibitors (JAKi) or immunosuppressants. The authors postulate immune mechanisms to explain the observed adverse effects. Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease #Allergy_journal

An Immunologic Perspective on Adverse Reactions Observed Upon Systemic Therapies of Atopic Dermatitis: A Retrospective Study of 145 Cases. First authors: Kathrin Thormann and Charlotte Arms; corresponding authors: Susanne Radonjic-Hoesli and Dagmar Simon

👉 doi.org/10.1111/all.70321

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This is a biographical article on Wesley Burks' life and the research that has shaped our current understanding of food allergy. Among his many contributions, he identified and characterised the major peanut allergens Ara h 1-3 (1991-1999); performed the first peanut allergy oral (2009) and sublingual (2011) #immunotherapy; demonstrated sustained unresponsiveness after egg oral immunotherapy, paving the way to the first FDA-approved OIT product for the treatment of peanut allergy. Read the stories of other Legends published in #Allergy here: journalallergy.com/Legends-of-Allergy-and-Immunology

This is a biographical article on Wesley Burks' life and the research that has shaped our current understanding of food allergy. Among his many contributions, he identified and characterised the major peanut allergens Ara h 1-3 (1991-1999); performed the first peanut allergy oral (2009) and sublingual (2011) #immunotherapy; demonstrated sustained unresponsiveness after egg oral immunotherapy, paving the way to the first FDA-approved OIT product for the treatment of peanut allergy. Read the stories of other Legends published in #Allergy here: journalallergy.com/Legends-of-Allergy-and-Immunology

Legends of Allergy & Immunology: A. Wesley Burks, MD: Advocate for Children's Health Through Scientific Discovery. M. Cecilia Berin, Stacie M. Jones, Edwin H. Kim, Hugh A. Sampson

Read the article here: doi.org/10.1111/all.70317

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This study analyzes the natural history of sesame over time and the changes in biomarkers between sesame-allergic and sesame-sensitised but tolerant children. The period prevalence of sesame allergy increased from 0.5% between 12 and 36 months to 1.5% between 7 and 12 y children in the EAT-On study with 10 children developing new sesame allergy. Sesame-sIgE and Ses i 1-sIgE are informative biomarkers in terms of SA development, persistence, and resolution. Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

This study analyzes the natural history of sesame over time and the changes in biomarkers between sesame-allergic and sesame-sensitised but tolerant children. The period prevalence of sesame allergy increased from 0.5% between 12 and 36 months to 1.5% between 7 and 12 y children in the EAT-On study with 10 children developing new sesame allergy. Sesame-sIgE and Ses i 1-sIgE are informative biomarkers in terms of SA development, persistence, and resolution. Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

Open access: The Evolution of Sesame Seed Allergy Over Time. Corresponding authors: Ru-Xin Foong, Alexandra Santos and Gideon Lack

Read the article here: doi.org/10.1111/all.70281

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Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report YouTube video by Allergy

F.Roth-Walter, I.Agache, B.Cabanillas, et al., “Iron Physiology and Its Impact on Atopic Diseases: An #EAACI Taskforce Report,” Allergy (2026): doi.org/10.1111/all.70325

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Accurate identification of the disease-causing allergen is essential for selecting the most appropriate allergen-specific #immunotherapy (AIT) vaccine. This is not always straightforward, as allergen extracts frequently contain cross-reactive allergens with similar structural and immunological features. Huang et al. present a molecular-based medical algorithm for the diagnosis of genuine-, co- and/or cross-sensitization to allergen sources. #Allergy_journal Read more medical algorithms published in #Allergy here: journalallergy.com/Medical-Algorithms

Accurate identification of the disease-causing allergen is essential for selecting the most appropriate allergen-specific #immunotherapy (AIT) vaccine. This is not always straightforward, as allergen extracts frequently contain cross-reactive allergens with similar structural and immunological features. Huang et al. present a molecular-based medical algorithm for the diagnosis of genuine-, co- and/or cross-sensitization to allergen sources. #Allergy_journal Read more medical algorithms published in #Allergy here: journalallergy.com/Medical-Algorithms

Open Access: Algorithms in Allergy: General Allergen Molecule-Based Algorithm for Allergen-Specific Immunotherapy. First author: Huey-Jy Huang; corresponding author: Rudolf Valenta

Read the article here: doi.org/10.1111/all.70278

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Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline (#epinephrine) showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and more potent shock therapies.

Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline (#epinephrine) showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and more potent shock therapies.

Open access: Effect of Intramuscular Adrenaline on Histamine‐Induced Hypotension: A Randomised Placebo‐Controlled Pilot Trial. First author: Matthias Weiss-Tessbach; corresponding author: Bernd Jilma

👉 doi.org/10.1111/all.70277

👉 journalallergy.com/Drug-Insect-Anaphylaxis

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Food Allergy-Induced Systemic Immune Alterations Affect Tumor Progression
Food Allergy-Induced Systemic Immune Alterations Affect Tumor Progression YouTube video by Allergy

X.Fan, S.Guo, W.Zhang, et al., “Food Allergy-Induced Systemic Immune Alterations Affect Tumor Progression in a CT26 Colon Adenocarcinoma Mouse Model,” Allergy (2026): Read the article here: doi.org/10.1111/all.70331

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Oxazolone exposure drives rapid basophil recruitment to wounded skin, accelerating re-epithelialization, angiogenesis, and tissue regeneration. Basophils are the dominant early source of IL-4 and IL-13 in the wound microenvironment. Basophil-derived IL-4/IL-13 promote macrophage polarization toward a pro-repair M2 phenotype, enabling efficient wound healing. Baso, basophil; EtOH, ethanol; IL, interleukin; Mcpt8, mast cell protease 8; mDC, mature dendritic cell; Mo, monocyte; МФ, macrophage; Neu, neutrophil; OXA, oxazolone.

Oxazolone exposure drives rapid basophil recruitment to wounded skin, accelerating re-epithelialization, angiogenesis, and tissue regeneration. Basophils are the dominant early source of IL-4 and IL-13 in the wound microenvironment. Basophil-derived IL-4/IL-13 promote macrophage polarization toward a pro-repair M2 phenotype, enabling efficient wound healing. Baso, basophil; EtOH, ethanol; IL, interleukin; Mcpt8, mast cell protease 8; mDC, mature dendritic cell; Mo, monocyte; МФ, macrophage; Neu, neutrophil; OXA, oxazolone.

Open access: Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization. First authors: Yufei Zhang and Xueting Peng; corresponding authors: Yumin Xia, Yale Liu

👉 doi.org/10.1111/all.70279

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Food allergies may manifest as a consequence of primary sensitization to an airborne allergen, such as in pollen-food syndrome (PFS). Asero et al. present a medical algorithm for the diagnosis of PFS and discuss treatment options. Read other medical algorithms published in #Allergy here: journalallergy.com/Medical-Algorithms

Food allergies may manifest as a consequence of primary sensitization to an airborne allergen, such as in pollen-food syndrome (PFS). Asero et al. present a medical algorithm for the diagnosis of PFS and discuss treatment options. Read other medical algorithms published in #Allergy here: journalallergy.com/Medical-Algorithms

Algorithms in Allergy: Diagnosis and Treatment of Pollen Food Syndrome. R. Asero, L. Cecchi, V. Pravettoni, E. Scala, D. Villalta

Read the article here: doi.org/10.1111/all.70286

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Airway chitinolytic activity is increased during type 2 airway inflammation. Inhaled chitin drives allergic sensitization and type 2 airway inflammation by promoting dendritic cell activation and migration. Genetic deficiency of endogenous chitinases does not markedly alter chitin-driven type 2 airway inflammatory responses. Read more articles published in #Allergy here on basic and translational allergy here: journalallergy.com/Basic-and-Translational

Airway chitinolytic activity is increased during type 2 airway inflammation. Inhaled chitin drives allergic sensitization and type 2 airway inflammation by promoting dendritic cell activation and migration. Genetic deficiency of endogenous chitinases does not markedly alter chitin-driven type 2 airway inflammatory responses. Read more articles published in #Allergy here on basic and translational allergy here: journalallergy.com/Basic-and-Translational

Chitin Is a Potent Inducer of Type 2 Airway Inflammation Independent of Endogenous Chitinolytic Activity. First author: Jozefien Declercq; corresponding author: Bart N. Lambrecht

Read the article here: doi.org/10.1111/all.70276

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Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision, Part II
Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision, Part II YouTube video by Allergy

R. J.Vieira, B.Sousa-Pinto, J.Bousquet, et al., “Allergic Rhinitis and Its Impact on #Asthma (ARIA)-#EAACI Guidelines—2024–2025 Revision: Part II—Guidelines on Oral and Ocular Treatments,” Allergy (2026), doi.org/10.1111/all....

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Luo et al. developed artificial intelligence-based nasal polyps subtype diagnosis system (NPSS), an AI-based system integrating microscopic images (MI), whole-slide images (WSI), and 3D reconstruction (3DNP) to classify inflammatory subtypes of nasal polyps. The system dramatically reduces diagnostic time and elevates pathologists' accuracy from 49%–52% to 89%–90%. NPSS-WSI provides superior prognostic value (area under the curve, AUC 86.64%), significantly enhancing clinical decision-making and recurrence prediction.

Luo et al. developed artificial intelligence-based nasal polyps subtype diagnosis system (NPSS), an AI-based system integrating microscopic images (MI), whole-slide images (WSI), and 3D reconstruction (3DNP) to classify inflammatory subtypes of nasal polyps. The system dramatically reduces diagnostic time and elevates pathologists' accuracy from 49%–52% to 89%–90%. NPSS-WSI provides superior prognostic value (area under the curve, AUC 86.64%), significantly enhancing clinical decision-making and recurrence prediction.

Artificial Intelligence-Based Pathological Subtype Diagnosis of Nasal Polyps: A Multidimensional and Micro-Visualization Study. First author: Xin Luo; corresponding authors: Haotian Lin, Lei Cui, Lin Yang, Qintai Yang

Read the article here: doi.org/10.1111/all.70282

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Atopic dermatitis (AD) patients show marked OX40 upregulation in effector and regulatory CD4+ T cells. Interaction with OX40L impairs Treg suppressive function, thereby sustaining Th2 activity and promoting inflammation. Thus, the OX40/OX40L axis drives impaired immune regulation and contributes to enhanced skin inflammation in AD. #Allergy_journal Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

Atopic dermatitis (AD) patients show marked OX40 upregulation in effector and regulatory CD4+ T cells. Interaction with OX40L impairs Treg suppressive function, thereby sustaining Th2 activity and promoting inflammation. Thus, the OX40/OX40L axis drives impaired immune regulation and contributes to enhanced skin inflammation in AD. #Allergy_journal Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

The OX40/OX40L Axis Promotes Th2 Activity and Impairs Regulatory T Cell Function in #AtopicDermatitis. First author: Kazuhiko Yamamura; corresponding author: Emma Guttman-Yassky

Read the article here: doi.org/10.1111/all.70252

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Staphylococcus aureus, commonly colonising cutaneous T cell lymphoma (CTCL) patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T-cell release of barrier-repressing cytokines (IL-4, IL-13, IL-22, oncostatin M). Cytokine signalling drives JAK-dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic-mediated eradication of S. aureus induces skin barrier protein expression and inhibits the inflammatory cycle.

Staphylococcus aureus, commonly colonising cutaneous T cell lymphoma (CTCL) patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T-cell release of barrier-repressing cytokines (IL-4, IL-13, IL-22, oncostatin M). Cytokine signalling drives JAK-dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic-mediated eradication of S. aureus induces skin barrier protein expression and inhibits the inflammatory cycle.

Open Access: Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma. First authors: Maria Gluud; corresponding authors: Terkild B. Buus, Niels Ødum

👉 doi.org/10.1111/all.70292

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The sharp rise in #allergic diseases during the past decades has been attributed to changes in allergen exposure driven by modernization and climate change. Early interventions are essential, such as tailored supplementary nutrition, early treatment of atopic dermatitis to slow down the atopic march, as well as breastfeeding and environmental campaigns to raise awareness. Allergen immunotherapy may prevent the development of allergic diseases and alleviate clinical symptoms.

The sharp rise in #allergic diseases during the past decades has been attributed to changes in allergen exposure driven by modernization and climate change. Early interventions are essential, such as tailored supplementary nutrition, early treatment of atopic dermatitis to slow down the atopic march, as well as breastfeeding and environmental campaigns to raise awareness. Allergen immunotherapy may prevent the development of allergic diseases and alleviate clinical symptoms.

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Frequency and Severity of Allergic Reactions to Non-Mandatory Labelled Allergenic Foods
Frequency and Severity of Allergic Reactions to Non-Mandatory Labelled Allergenic Foods YouTube video by Allergy

S.Dölle-Bierke, A.Gonzalo-Fernández, D.Sabouraud-Leclerc, et al., “Frequency and Severity of Allergic Reactions to Non-Mandatory Labelled Allergenic Foods—Data From Two Large European Cohorts,” Allergy (2026), Read the article here: doi.org/10.1111/all.70308

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Learn what makes a great scientific graphic, from layout and color to clarity and accuracy. Perfect for authors preparing submissions to Allergy or any scientific publication.

Learn what makes a great scientific graphic, from layout and color to clarity and accuracy. Perfect for authors preparing submissions to Allergy or any scientific publication.

🚀 One of our most visited pages in 2025!

Our page explains the basics of creating effective Graphical Abstracts — clear, visual summaries that help readers grasp your findings in seconds.

🔗 Read the guide: journalallergy.com/Graphical-Abstracts

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Zhao et al. demonstrate the role of keratinocyte TRPV3 as a critical driver of IL-33-mediated mast cell recruitment and inflammation in atopic dermatitis (AD). TRPV3 knockout mice exhibited significant reductions in perivascular mast cell density. In a mouse model of AD, inhibition of TRPV3, or the upstream protease-activated receptor 2 (PAR2), reduced IL-33 expression in the epidermis. The TRPV3-IL-33 axis was further demonstrated to regulate AD-associated substance P expression and neuro-mast cell interactions.

Zhao et al. demonstrate the role of keratinocyte TRPV3 as a critical driver of IL-33-mediated mast cell recruitment and inflammation in atopic dermatitis (AD). TRPV3 knockout mice exhibited significant reductions in perivascular mast cell density. In a mouse model of AD, inhibition of TRPV3, or the upstream protease-activated receptor 2 (PAR2), reduced IL-33 expression in the epidermis. The TRPV3-IL-33 axis was further demonstrated to regulate AD-associated substance P expression and neuro-mast cell interactions.

Open Access: Epidermal PAR2-TRPV3-IL-33 Signaling Promotes Mast Cell Recruitment and Sensory Nerve-Mast Cell Interactions in #AtopicDermatitis. First authors: Jiahui Zhao, LingXuan Zhou, and Chenyu Wang ; corresponding author: Miao Jing

👉 doi.org/10.1111/all.70284

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Reduced Cord Blood B10 Cells in infants with atopic dermatitis of the Munich Atopy Prediction Study
Reduced Cord Blood B10 Cells in infants with atopic dermatitis of the Munich Atopy Prediction Study YouTube video by Allergy

K.Yamamura, S.Garcet, J.Gonzalez, et al., “Sphingosine 1-Phosphate Receptor 1 and 5 Reciprocally Regulate IL-13 and IL-9 Production in Atopic Dermatitis,” Allergy (2026), doi.org/10.1111/all.70299

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Evaluation en vie Réelle de l'Allergo-Prescription en Pratique (ERAPP) is a large, prospective, real-world cohort of children and adults initiating named-patient product sublingual #immunotherapy (NPP-SLIT) in France. More than 80% of patients reported a clinically meaningful, expectation-anchored benefit (Patient Benefit Index ≥ 1) at 12–15 months. The Patient Benefit Index complements conventional patient-reported outcome measures by capturing what matters most to patients in routine allergy care.

Evaluation en vie Réelle de l'Allergo-Prescription en Pratique (ERAPP) is a large, prospective, real-world cohort of children and adults initiating named-patient product sublingual #immunotherapy (NPP-SLIT) in France. More than 80% of patients reported a clinically meaningful, expectation-anchored benefit (Patient Benefit Index ≥ 1) at 12–15 months. The Patient Benefit Index complements conventional patient-reported outcome measures by capturing what matters most to patients in routine allergy care.

Open Access: Patient-Perceived Benefits of Named-Patient Product Sublingual #Immunotherapy in Allergic Rhinitis and Asthma: Primary Results From the ERAPP Real-World Cohort Study. Corresponding author: Davide Caimmi

👉 doi.org/10.1111/all.70270

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Intramuscular Adrenaline Fails to Reverse Histamine-Induced Hypotension
Intramuscular Adrenaline Fails to Reverse Histamine-Induced Hypotension YouTube video by Allergy

M.Weiss-Tessbach, A. M.Dizdarevic, T.Bischof, et al., “Effect of Intramuscular Adrenaline on Histamine-Induced Hypotension: A Randomised Placebo-Controlled Pilot Trial,” Allergy 👉 doi.org/10.1111/all.70277

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New treatment alert? #PITT_ID26

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