Repair of DNA double-strand breaks leaves heritable impairment to genome function Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Evidence for Hadean mafic intrusions in the Nuvvuagittuq Greenstone Belt, Canada Many questions remain regarding Earth’s earliest crust owing to the rarity of Hadean (>4.03 billion-year-old) rocks and minerals. The Nuvvuagittuq Greenstone Belt (NGB) in Canada may be the only known...

The Nuvvuagittuq Greenstone Belt— a complex geological sequence in northeastern Canada—harbors surviving fragments of Earth’s oldest crust, dating back to ~4.16 billion years old, according to a new Science study.

Learn more: scim.ag/3FXN8sq

Targeted p63 isoform switch corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasis www.biorxiv.org/content/10.1101/2025.06....

Please join us for our 2025 mini-symposium on translational biomarkers and clinical prediction.

www.qmul.ac.uk/bcsc/events/...

High UK visa costs deter international scientists and engineers It took Ed Roberts over a year to find a senior scientist to work at his cancer research laboratory in Scotland, a delay he blames on high UK visa costs that made it harder to attract international workers.

#InTheNews: Read in @reuters.com about how high UK visa fees for scientists are impacting our research institutes and our mission to beat cancer 👇 www.reuters.com/world/uk/hig...

Skin damage signals mediate allergic sensitization to spatially unlinked antigen Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.

#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!

75% of US scientists who answered Nature poll consider leaving More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪

www.nature.com/articles/d41...

Celebrating 20 Years of the International Pachyonychia Congenita Consortium.
Read Coulombe et al's News & Perspective Commentary in the April issue.
doi.org/10.1016/j.ji...
#DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch #dermscience #dermatologyresearch

Matrix-producing neutrophils populate and shield the skin - Nature A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

Nature research paper: Matrix-producing neutrophils populate and shield the skin

https://go.nature.com/4iJSgy5

Student Placement Scheme Research internships available for undergraduate students Apply by 30 March 2025

📢 Calling all undergraduates looking for hands-on academic research experience!
There’s still time to apply for the LMB’s Student Placement Scheme.
Visit our website to learn more and get your applications in by 30th March.
www2.mrc-lmb.cam.ac.uk/students/stu...

A big thank you to Carsten Gram Hansen and @edinburgh-uni.bsky.social, Institute for Regeneration and Repair for hosting me. Really enjoyed my stay and learning all about the fantastic research in the Centre for Inflammation Research.

Peptic Ulcer Disease JAMA Patient Page

A peptic ulcer is a break in the lining of the lower esophagus, stomach, or upper small intestine. This JAMA Patient Page describes peptic ulcers and their causes, signs and symptoms, diagnosis, and treatment options. https://ja.ma/4bzikcU

Screenshot of interview

Wrestling with the RAS cancer drug pipeline
tinyurl.com/54faf7kv

Alice Shaw of the Dana-Farber Cancer Institute discusses the newly launched Center for RAS Therapeutics and the key role of combination strategies in building on the initial breakthroughs with RAS inhibitors
@danafarber.bsky.social

A Decade of Cuts in a Matter of Days The Trump administration’s rapid terminations of NIH grants is its most aggressive attempt yet to control American science.

NIH officials were told this morning that approximately 1,000 more grants would be targeted for termination www.theatlantic.com/health/archi...

‘My career is over’: Columbia University scientists hit hard by Trump team’s cuts The US government has begun slashing US$400 million in research grants at Columbia University over pro-Palestinian campus protests.

🚨This week, many Columbia scientists lost grants that funded over half their annual income. Others will no longer be able to do research that helps treat thousands of sick patients across the US.

"It hurts," they told me.

My story for @nature.com 🧪

www.nature.com/articles/d41...

It is shocking and saddening to see how the two former global science powerhouses, USA and UK are collapsing in front of our eyes. For different reasons, but ultimately it’s about politics in both cases.

Happy #InternationalWomensDay2025 from a PI with an all-female team of fantastic scientists 🇫🇷🇸🇦🇮🇹🇬🇷

Vesuvius volcano turned this brain to glass The brain of a man who died nearly 2000 years ago was turned to glass by extreme conditions during the eruption of Mount Vesuvius. Researchers studied the strange material found in the man’s skull and spine and deduced the presence of a super-heated ash cloud that would have caused the tissue to first liquify then rapidly cool into glass - a unique event that has even preserved some brain structures. Read the paper here: https://go.nature.com/4bnpr81 For more stories like these sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday: https://go.nature.com/371OcVF

The brain of a man who died nearly 2000 years ago was turned to glass by extreme conditions during the eruption of Mount Vesuvius. Researchers believe a super-heated ash cloud triggered the transformation. https://go.nature.com/3Dd0XBM

Watch the video: https://go.nature.com/3Dt4pIt 🧪 🏺

Scientists aiming to bring back woolly mammoth create woolly mice Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants

GIVE THEM TRUNKS YOU COWARDS

www.theguardian.com/science/2025...

I’ve been yearning to put in this out of office reply 😎

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

We at Nature denounce this assault on science 🧪 www.nature.com/articles/d41...

QWENDY: Gene Regulatory Network Inference Enhanced by Large Language Model and Transformer www.biorxiv.org/content/10.1101/2025.02....

Amazing! Congrats Dr Lawaetz and excellent supervisory team 🥳

Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.

Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw

Postdocs and PhD students hit hard by Trump’s crackdown on science As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

Postdocs and PhD students - the future of the US research - hit hard by Trump’s crackdown on science

🧪 #academicSky #ECRs

@nature.com

www.nature.com/articles/d41...

Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees High living costs paired with stagnant stipends are being blamed for a drop in PhD enrolments in several countries.

Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees www.nature.com/articles/d41...

Join the Molecular Drug Targeting Lab at the University of Vienna!
I have a vacant postdoc position for a qualified candidate: either with a background in delivery technologies or immunology.

jobs.univie.ac.at/job/Universi...

Science can be so much fun: trying to deposit a massive proteomics data set on PRIDE. Upload tool is JAVA-based (eye roll), and University does not allow JAVA install on IT managed device…

Thanks a lot for having me @nucancer.bsky.social. I had a great time! Really enjoyed learning about all the exciting cancer research happening in this Northern powerhouse!

Cardiff University to cut 400 staff and drop subjects including nursing and music Union describe reductions as ‘cruel’ as university says it will run out of money without changes

Sorry to hear this about @cardiffuni.bsky.social
Losing 400 faculty means Cardiff Uni is now mostly employing administrators (they currently have 3660 admin to 3410) academics according to their website). At what point do you stop being an academic institution? www.theguardian.com/education/20...