Engineering Synthetic LRR Sensors to Generate Bespoke NLR Immune Receptors for Soybean Disease Resistance at Imperial College London on FindAPhD.com PhD Project - Engineering Synthetic LRR Sensors to Generate Bespoke NLR Immune Receptors for Soybean Disease Resistance at Imperial College London, listed on FindAPhD.com

Industry-funded #EngBio / #SynBio #PhD positions starting October 2026 at @ImperialLifeSci www.findaphd.com/phds/project...

Homing gene drive schematic and per-species drive inheritance. (a)Overview showing a CRISPR-Cas9 hominggene drive converting a wild-type allele into a drive allele via inter-homologue gene conversion, alongside alternative outcomes(e.g., retention of the original allele or resistance allele formation).(b)Empirical drive-allele inheritance rates are shown for eachspecies, with each point representing unique crosses (meta-data defined replicates merged).An. coluzziiis a member of theAn.gambiaespecies complex. Point size scales with progeny scored. The colour legend indicates species phylogeny. Confidenceintervals (dark grey lines) reflect precision of the predicted mean (black point); prediction intervals (light grey lines) reflect theexpected range for a new observation

New pre-print!
Excited to share our new paper — the first meta-analysis of CRISPR-based homing gene drives! Analysing nearly one million scored progeny across 42 studies and 10 species.
www.biorxiv.org/content/10.6...

@sebaldv.bsky.social @nikiwind.bsky.social
@eivimeycook.bsky.social

3D-Feedy: An open and portable membrane feeder for mosquito research bioRxivpreprint

How Nuclear Flies Protect You from Flesh-Eating Parasites YouTube video by Kurzgesagt – In a Nutshell

@kurzgesagt.org‬ takes on SIT... The kids love it. www.youtube.com/watch?v=zxq6...

Bill Gates talking about #genedrive as one of the tools in the pipeline that could help end #malaria in the next 20 years @transmission-zero.bsky.social @targetmalaria.org

Thanks Dafners. There is a gut angle here, so maybe you can give us some tips of what might be actually happening here!

Great @transmission-zero.bsky.social teamwork with @sebaldv.bsky.social taming the beast and Prashanth Selvaraj spinning up the model!

We need to know much more about the complex fitness effects we observe and how they would translate to the field.

Gene drives that affect vector longevity and induce bloodmeal-specific mortality are predicted to be highly effective in reducing malaria transmission as we show in our model.

Targeting ultraconserved RNA genes (like some naturally occurring HEGs do) is an alternative approach for pre-empting resistance (dancing around the degeneracy of the genetic code with multiple gRNAs just kicks the can down the road for protein coding genes).

It's target sire is conserved far beyond Diptera, and hence is present in Anopheles gambiae, arabiensis, coluzzii and funestus.

We describe (one of) the most promising gene drives for malaria control so far. This drive shows near perfect inheritance bias but doesn't fall neatly into the suppression/modification categories.

A suppression-modification gene drive for malaria control targeting the ultra-conserved RNA gene mir-184 - Nature Communications Here, the authors describe a highly efficient gene drive targeting the non-coding miR-184 gene. Disruption of the miR-184 gene by the gene drive reduces mosquito lifespan and interferes with survival ...

New paper/gene drive from the lab! Dropped by NComms on Friday evening on World Malaria Day of all times - without a word of warning….

www.nature.com/articles/s41...

#transgenic #xmas
(by Paolo Capriotti) 🎄🎅⛄🎁 🧬🪰🔬

#transgenic #xmas
(by PhD student Serafima Davydova) 🎄🎅⛄🎁 🧬🪰🔬

We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!!
www.imperial.ac.uk/jobs/search-...

First post! #transgenic #xmas (by PhD student James Fawcett) 🎄🎅⛄🎁 🧬🪰🔬