Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration The evolution and development of eyes are fundamental problems in biology, and numerous genetic and age-related degenerative eye diseases are still po…

Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration - Cell Reports
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Introns as Protective Buffers Against Transposable Elements Invasion During Genome Gigantism in a Newt - Bou - 2026 - Genes to Cells - Wiley Online Library
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Trans-regenerational RNAi Memory in Planarians | bioRxiv
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Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration | bioRxiv
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Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians Planarian extracellular vesicles carry small RNAs that mediate systemic gene silencing and coordinate regeneration.

Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians | Science Advances
www.science.org/doi/10.1126/...

RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a | Nature Communications
www.nature.com/articles/s41...

Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea Highly regenerative animals often have a seemingly limitless capacity for tissue growth and stem cell proliferation, which often requires molecular and organismal capacities associated with pre-malign...

Activin/TGF-beta signaling levels coordinate whole-body regeneration with genotoxic stress in Schmidtea mediterranea | bioRxiv
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ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket Many animals regenerate lost body parts through several signalling pathways; however, the triggers that initiate regeneration remain unclear. In the present study, we focused on the role of reactive o...

ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket | Development | The Company of Biologists
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Identification of an innexin required for termination of the asexual state in planarian reproductive switching Author summary Some animals have pluripotent stem cells that can differentiate into all types of cells that make up their adult bodies. Thus, they can regenerate after self-amputation and reproduce as...

Identification of an innexin required for termination of the asexual state in planarian reproductive switching | PLOS Genetics
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Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation Development of alternative methods for analysis of reproductive toxicity is a challenge that requires the characterization of mechanistic endpoints li…

Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation - ScienceDirect
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egal-1 and microtubules promote regeneration polarity in planarians Summary: The planarian head-tail regeneration choice requires selective activation of Wnt-inhibitory notum at anterior-facing wounds, a polarized process that requires an Egalitarian-like protein and ...

egal-1 and microtubules promote regeneration polarity in planarians | Development | The Company of Biologists
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The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians Zoology; Phylogenetics; Evolutionary biology; Phylogeny

Paper out! Collaborative decoding of the Iberian ribbed newt genome in iScience

The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians: iScience

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Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense Current understanding of cytotoxic immunity is shaped by hematopoietic-derived cells -- T cells, natural killer cells, and neutrophils. Here, we identify 'ruptoblasts', a previously unknown cytotoxic ...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
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SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine. However, few in vivo models enable studying how stem cell fates are specified as neurons in an adul...

SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians | bioRxiv
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Genetic and Genomic Insights into Planarian Biology | Annual Reviews
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Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl Cell tracing is an essential method for deciphering cellular processes during organ regeneration. We generated transgenic Iberian ribbed newts carrying the multicolor reporter Brainbow3.0 cassette un...

Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl - Hayashi - Development, Growth & Differentiation - Wiley Online Library
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2025年8月号｜日経サイエンス 天体物理学 特集：認知の原点を探る 人工知能がこれだけ発展しても，私たちはまだ自らの知能についてよく理解できていない。プラナリアの脳再生や動植物の賢い振る舞い，AIとロボットの関係など多様な視点から生物の認知機能を見つめ … 続きを読む →

「プラナリアの体が宿した"記憶"」
少しだけコメントさせていただきました。
www.nikkei-science.com/page/magazin...

Step‐by‐Step Protocol for Making a Knock‐In Xenopus laevis to Visualize Endogenous Gene Expression - Kagawa - Development, Growth & Differentiation - Wiley Online Library
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Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs Previous studies suggested the importance of the reciprocal interactions between residual tissues, which we refer to here as the “stump”, and the newl…

our paper is out!

Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs - ScienceDirect
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Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea N6-methyladenosine (m6A) is one of the most prevalent post-transcriptional modifications of eukaryotic RNA molecules. This post-transcriptional modification is essential in biological contexts ranging...

Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea | bioRxiv
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A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen - BMC Genomics Background The isolation of intact, high-molecular-weight genomic DNA (HMW gDNA) is essential for achieving complete genome assemblies. However, extracting HMW gDNA from a single individual of Dugesia...

A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen | BMC Genomics
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Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons During regenerative neurogenesis, neurons must be created in the right types and locations. Though regenerative neurogenesis is limited in humans, other animals use regenerative neurogenesis to faithf...

Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons | bioRxiv
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Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians POU4 homologs are involved in the development of sensory cell types across diverse species, including cnidarians, ascidians, and mammals. Whether these developmental regulators are reused during adult...

Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians | bioRxiv
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Frontiers | Planarian RNAi knockdown: feeding once might just be enough
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Developmental onset of planarian whole-body regeneration depends on axis reset Booth et al. show that the planarian Schmidtea polychroa gradually gains its impressive regenerative abilities during development. While regeneration involves many factors, this study shows that the r...

Developmental onset of planarian whole-body regeneration depends on axis reset: Current Biology
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Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro...

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - 2025 - Development, Growth & Differentiation - Wiley Online Library
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Regeneration leads to global tissue rejuvenation in aging sexual planarians - Nature Aging The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immort...

Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging
www.nature.com/articles/s43...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense Cytotoxic killing is an essential immune function, yet its cellular mechanisms have been characterized in only a few model species. Here, we show that planarian flatworms harness a unique cytotoxic st...

Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...

Temporal integration and active sensing of light in planarians Animal light sensing and processing are intimately connected to the design of the sensory apparatus, with eye-design a subject of longstanding interest. Understanding animal response to stimuli can el...

Temporal integration and active sensing of light in planarians | bioRxiv
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Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells - BMC Genomics Background The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types...

Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells | BMC Genomics |
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