Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...

📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...

Doctoral Student in Tumor Biology Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo

🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...

And here's @rebeccarosberg.bsky.social (with others) accepting her poster prize to conclude a wonderful symposium in Paris 🤩🔥🧠🇫🇷

At the Brain Tumor Microenvironment Symposium @institutducerveau.bsky.social, Sebastian Braun presented our comprehensive study of pericytes in GBM 🤩. Pericytes act as guardians of the peri-vascular niche to prevent malignant cell invasion, read more at www.biorxiv.org/content/10.1...

...and here's Karolina Smolag @karolinasmolag.bsky.social delivering the second Pietras lab talk of the day 🤩 We also have a couple of posters so please check them out if you're with us in Paris!

We're excited to be at the Institute du Cerveau in Paris for the brain tumor microenvironment symposium 🧠 Here's Pauline Jeannot with the first presentation of the day from the lab 🔥

A new mechanism reveals how Tregs are sustained in the glioma microenvironment, negatively impacting patient survival

🎉 Thrilled to share our latest paper from Anna Blom's lab in collaboration with @pietraslab.bsky.social

Full story in Cancer Immunology Research: aacrjournals.org/cancerimmuno...

Thank you 🥰 I agree. It has given me so much (unwanted) insights, but I hope in the end it will lead to more inspiring ideas and understanding of this stupid disease

❤️🤩

Meet our PhD student Rebecca! This year, she beat cancer AND published her first 1st-author paper on how hypoxia induces complement signaling in GBM, alters macrophage polarization, and how the C3-C3AR1 axis can be therapeutically targeted in GBM models. Check it out! insight.jci.org/articles/vie...

Inspired by the other amazing starter packs - here's one for cancer researchers!

I tried to make this broad - from immunology to genomics to cell biology and so much more..

This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺

Hope its useful!

go.bsky.app/FEoaJMc

Hi Blue! Sharing my personal journey as a cancer researcher & cancer patient. Exploring the beauty of tumor complexity and getting a first-hand view into how therapy can change the outcome of patient lives.

We love to explore unexpected findings 🤔 Check out our two latest studies detailing the unexplored expression of ALK1 in immunosuppressive macrophages and the critical role of pericytes as a paracrine signaling hub in GBM.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...