What a great question to ask

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

Thanks for sharing this

What Zendaya Leaves Unsaid Her films rarely center on—or even acknowledge—her race, seemingly out of concern that focussing on identity might limit her characters’ emotional palettes. But why couldn’t it expand those palettes?

this piece brings up a great point about how her characters being unambiguously black during her child star years makes the shift to all these sort of “raceless” characters in her turn to film and serious adult acting roles all the more jarring.

www.newyorker.com/culture/crit...

Andrew seemed Ok, until that one summer when he discovered random seeds.

Then the troubles started...

oooooooof isn't it a bad feeling to think you are being invited to something because of your work, and then have an organizer NOT TELL YOU they are putting you on a "diversity track" that you didn't know existed, where they are applauding themselves for elevating people like you

This is a horrifying thread about Target, AI, facial recognition, self check out, and the justice system. Things that should NEVER go together.

a/s/l?

The TomiTom Sho - Sonder - Bakersfield, CA 12-20-25 (full show) YouTube video by Pongo Mousike

Was blown away by this pair of minstrels recently, busking on the street in Joshua Tree. Here they are at a Sonders in Bakersfield. They're both pretty damn proficient string pickers and to me her voice is damn amazing. Covers and originals.

the factor-analysis student in me can't get past the finding that... the best predictor of a composite score is a follow-up question on the same survey about one of the composite's component questions. which is fine. that can answer "why". but the "right variables" question is funny at that point

Comparison maps over California of annual average temperature anomalies in the year 2022 from the low-resolution and high-resolution versions of Berkeley Earth.

Comparison maps over California of annual average temperature in the years 1951 to 1980 from the low-resolution and high-resolution versions of Berkeley Earth.

The transition last year from the old @berkeleyearth.org temperature analysis to the new high-resolution version doesn't make much difference for the global averages, but it is really useful when it comes to capturing local and regional details that would otherwise be missed.

Tennessee Senate Passes Amended Trans Healthcare Tracking Bill As Tennessee State Senators came to the floor on Monday afternoon, about two dozen activists formed a wall in the hallway, singing to the lawmakers.

The Tennessee legislature has now passed the trans registry bill requiring all medical information about trans people, including therapy notes, diagnoses, and prescriptions be reported to the state so it can be published to the public.

apnews.com/article/tenn...

It's me, the no-nonsense progressive who gets shit done. I think the people making pennies picking strawberries while they flee from the gestapo are getting a little too greedy.

Ok, update, I now better understand async vs parallel processing, why they're useful, and I can only sit here and feel mad that I didn't know how to use them in undergrad and grad school when I was setting alarms to check my laptop every few hours overnight 🫠 My other cores were just SITTING THERE??

Sometimes* it do be like that.

*all the time

The author list on this is pretty great. Nice work.

I am so happy that this has finally seen the light of day. On the one hand, it seems an obvious answer to an obvious question, but it needed to be done.

And I'm never gonna start harping on the bit about the Spice Girls. Ever.

Fair to say, according to these estimates, we do not have good estimates of what true "desistance" rates are for trans youth.

Genomic dissection of methane emission traits in cattle: A meta-GWAS and heritability analysis across populations Enteric methane emissions from ruminants represent a significant contributor to agricultural greenhouse gases, necessitating precise genetic tools to guide mitigation strategies. This study aimed to i...

Finally, a fart-GWAS.

Sounds like they know borders are tyranny?

The mass exclusion and purge of immigrants from the United States was never primarily about law-and-order. That was a lie that remained a lie as it was repeated ad nauseam.

"Mr. Khan is the C.E.O. of Khan Academy and the vision steward at TED..."

Diverging Color Maps for Scientific Visualization One of the most fundamental features of scientific visualization is the process of mapping scalar values to colors. This process allows us to view scalar fields by coloring surfaces and volumes. Unfor...

Kenneth Moreland's "cool-warm" palette is a good choice (a blue-neutral-red ramp): link.springer.com/chapter/10.1...

More recent empirical work from Khairi Reda seems to find that it holds up: doi.org/10.1145/3173...

No matter how stupid and evil you think the MAGA chuds running the government are, I promise you: the truth is so much more stupid and evil.

"I'm sorry ma'am, those calories are not authorized for your status level. Please consult the handbook for further guidance."

Carl Bergstrom presenting his research. The slide on the screen says "Science is perhaps the greatest human invention."

inspo for all

just finished my taxes. using turbotax (ick) for the frist time in a few years. both fed and state effective tax rates it computed were LESS than income divided by Total Tax (AGI for fed and taxable income for CA).

What could possibly be the motivation for this?

A painting of a stormy dark sky over a small shack in a prairie.

My painting DARK STORM

indeed. fried.

it's a sorta fun low stakes example of what's right about standpoint theory. they tend to say really silly things!