Left: Antoine Sussfeld. Right: Berta Vidal (front left), Oliver Hobert (back) and Surojit Sural (front right).
To learn more about this work and the people behind it, we talked to Antoine Sussfeld, Berta Vidal, Surojit Sural @surojitsural.bsky.social and Oliver Hobert. journals.biologists.com/dev/article/...
Read the Research Article 'A conserved C. elegans zinc finger homeodomain protein, ZFH-2, is continuously required for the structural integrity and function of the alimentary tract and gonad' here.
journals.biologists.com/dev/article/...
![Post-embryonic removal of ZFH-2 protein results in pumping defects. (F) DIC images of the pharyngeal-intestinal valve (vpi) in zfh-2(syb10278); osIs158[eft-3p::TIR1(F79G)] adults subjected to ubiquitous ZFH-2 depletion starting at mid-L1 stage. Animals were treated with either solvent (ethanol) or 100 µM 5-Ph-IAA starting at mid-L1. Scale bars: 10 µm.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:btitwyhiegkb6f62oguxt6m6/bafkreidgzspfg245razwu2eq237gairwetwlpsf3k2eycqo2y67ve6z3ce)
Post-embryonic removal of ZFH-2 protein results in pumping defects. (F) DIC images of the pharyngeal-intestinal valve (vpi) in zfh-2(syb10278); osIs158[eft-3p::TIR1(F79G)] adults subjected to ubiquitous ZFH-2 depletion starting at mid-L1 stage. Animals were treated with either solvent (ethanol) or 100 µM 5-Ph-IAA starting at mid-L1. Scale bars: 10 µm.
From eating to mating: ZFH-2 is required for alimentary tract and gonad development in worms
This Research Highlight showcases work by Antoine Sussfeld, Oliver Hobert, @surojitsural.bsky.social & co. @columbiauniversity.bsky.social @hhmi-science.bsky.social
journals.biologists.com/dev/article/...
Attending 'Modeling Life from Cells to Tissues: Emergence and Self-Organization' by @lakeconferences.bsky.social?
Editors, @jamesbriscoe.bsky.social, @pfrancois.bsky.social, @irenemiguel-aliaga.bsky.social & Matthias Lutolf, are present - chat to them about publishing with us.
tinyurl.com/yvrse8se
James introducing his work on neural patterning
James advertising Development and its initiatives
Editor in chief of Development @jamesbriscoe.bsky.social opening the floor today at the Allen Institute Lake Conference 2026 meeting ! @biologists.bsky.social
Promotional graphic for a Development webinar announcing the Outstanding Paper Prize. The slide shows the date and time (Wednesday 29 April, 15:00 BST), chair Steve Wilson, and two speakers with headshots and paper titles, alongside a colorful fluorescent microscopy-style image and a QR code, with The Company of Biologists and Development logos at the bottom.
📢 Register for our #DevPres webinar featuring the finalists of the 2025 Outstanding Paper Prize
The webinar, chaired by Steve Wilson, features talks from Xi Yang and Bénédicte Lefèvre @drosopachea.bsky.social.
🗓️29 April, 15:00 GMT/UTC
us02web.zoom.us/webinar/regi...
Attending the @bscb-official.bsky.social tomorrow?
Be sure to visit the @biologists.bsky.social exhibit and chat with our colleagues at @jcellsci.bsky.social.
Also, take a look at our 2026 cell biology subject collection, curated by @swathiarur.bsky.social.
journals.biologists.com/dev/collecti...
These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9
I almost forgot: a big thank you to Development's @dev-journal.bsky.social editorial and production teams for being supportive, flexible and responsive re: editorial communication and deadlines, during a period when I faced a serious health problem. It means a lot to have this support.
Graphical card for the seapker Anna Beaudin and her talk "Developmental origins of tissue immunity: modelling the effects of early life inflammation" at Human Development: Stem Cells, Models, Embryos 7-9 September 2026 at the University of Warwick in the UK.
Anna Beaudin @beaudinlab.bsky.social will be speaking on "Developmental origins of tissue immunity: modelling the effects of early life inflammation" at our Journal Meeting in the UK this September. #HumanDev26
Register to attend: biologists.com/meetings/dev...
Early-bird deadline: 8 May 2026
Promotional graphic for a Development webinar announcing the Outstanding Paper Prize. The slide shows the date and time (Wednesday 29 April, 15:00 BST), chair Steve Wilson, and two speakers with headshots and paper titles, alongside a colorful fluorescent microscopy-style image and a QR code, with The Company of Biologists and Development logos at the bottom.
📢Register for our #DevPres webinar featuring the finalists of the 2025 Outstanding Paper Prize
The webinar, chaired by Steve Wilson, features talks from Xi Yang and Bénédicte Lefèvre @drosopachea.bsky.social.
🗓️29 April, 15:00 GMT/UTC
us02web.zoom.us/webinar/regi...
Register for On Demand Access to @keystoneSymposia.bsky.social #StemCell Models of #Embryology, to explore emerging research #KSEmbryology26
Visit hubs.la/Q03VtrQK0 and click on Pricing & Registration
Congratulations to the @dev-journal.bsky.social 2025 Outstanding Paper nominations, & special mention to the winner by Yang et al doi.org/10.1242/dev....
For the top three nominations and an interview with the winners see:
journals.biologists.com/dev/article/...
‼️The registration for the Development Journal Meeting 2026 - Human Development: Stem Cells, Models, Embryos is now open. This year marks a collaboration between @dev-journal.bsky.social and the Human Developmental Biology Initiative consortium.
www.biologists.com/meetings/dev...
Deeply honored to be among the finalists of
@dev-journal.bsky.social 's 2025 Outstanding Paper Prize for the latest article of my PhD, together with Michael Lang, @courtier-orgogozo.bsky.social and our colleagues!
doi.org/10.1242/dev.204662
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Event image card: Human Development: Stem Cells, Models, Embryos Date: 7 – 9 September 2026 Location: University of Warwick, UK
One month until early-bird deadline for @dev-journal.bsky.social & @wellcometrust.bsky.social-funded consortium HDBI's 2026 Meeting on Human Development: Stem Cells, Models, Embryos. Check out the programme biologists.com/meetings/dev... and register by 8 May www.biologists.com/meetings/dev...
Amrita Singh (left) and Shubha Tole (right)
To learn more about this work and the people behind it, we talked to Amrita Singh and Shubha Tole. journals.biologists.com/dev/article/...
Read the Research Article 'Cajal-Retzius fate specification is disrupted by constitutive activation of β-Catenin in hem progenitors' here.
journals.biologists.com/dev/article/...
Canonical WNT signaling in the cortical hem and the CR cell lineage. (A) The Ai9 reporter driven by Lmx1aCre is detected the cortical hem and its derivatives (arrowheads, CR cells; open arrowhead, choroid plexus epithelium) in an E13.5 Lmx1aCre; Ai9 brain, and WNT3A protein is detected in the hem.
WNT activity disrupts early neuronal fate specification
This Research Highlight showcases work by Amrita Singh @amritacantsing.bsky.social, Shubha Tole @shubhatole.bsky.social and colleagues.
journals.biologists.com/dev/article/...
@dev-journal.bsky.social’s 2025 outstanding paper prize. The top nominees include a fetal human heart atlas from the group of Heather Etchevers and Stéphane Zaffran, that I nominated journals.biologists.com/dev/article/...
Congratulations to our other finalist, Bénédicte Lefèvre @drosopachea.bsky.social , Michael Lang et al, a paper which brings together evolutional developmental biology, morphogenesis and behavioural studies.
doi.org/10.1242/dev....
Congratulations to our other finalist, Christopher De Bono, Stéphane Zaffran, Heather Etchevers
@etche.bsky.social et al, a paper which examines early human heart development using a set of imaging techniques that unveil remarkable and unusual detail and richness. doi.org/10.1242/dev....
Screenshot of a journal editorial webpage titled “Development’s 2025 Outstanding Paper Prize,” dated 8 April 2026. Authors listed are James Briscoe, Alex Eve, and Steve Wilson. The page introduces the Outstanding Paper Prize, includes article information, a DOI link, and text recognising papers published in Development in 2025.
Congratulations to Xi Yang, Yun Zhou & co for winning our 2025 Outstanding Paper Prize. Their paper addresses broad & long-standing questions about how cells become new stem cell populations in the fern Ceratopteris.
Read the Editorial: doi.org/10.1242/dev....
Paper: doi.org/10.1242/dev....
Catch up on Development presents… webinar on neural development
Our February webinar featured early-career researchers studying neural development. Here, we share the talks from Joaquín Navajas Acedo @mads100tist.bsky.social & Carlo Donato Caiaffa. #DevPres
thenode.biologists.com/catch-up-on-...
Event graphic for the HDBI Development meeting. Black background with title “Human Development: Stem Cells, Models, Embryos,” 7–9 September 2026, University of Warwick, UK. Talk titled “Using organoids to interrogate human development and cellular heterogeneity” by Jason Spence, University of Michigan, USA. Includes a portrait of the speaker and a colourful spherical cell image. #HumanDev26
Jason Spence will be speaking on "Using organoids to interrogate human development and cellular heterogeneity" at our Journal Meeting in the UK this September #HumanDev26
Register to attend: biologists.com/meetings/dev...
Early-bird deadline: 8 May 2026
Model for relationships among LPR-1, LPR-3 and SCAV-2. (A) LPR-1 and SCAV-2 function to deliver and clear, respectively, an unknown lipophilic cargo (pink circles) that helps to promote assembly or retention of LPR-3 in the aECM. It is also possible that LPR-1 and SCAV-2 transport distinct cargos that each impact LPR-3 (not shown). LPR-3 matrix association is conferred by its unique N-terminal domain (Forman-Rubinsky et al., 2017). LPR-3 is presumed to carry a different cargo (purple squares) since the LPR-1 and LPR-3 cup domains are not interchangeable (Forman-Rubinsky et al., 2017). (B) In the absence of LPR-1, cargo levels drop below the level needed to efficiently recruit or retain LPR-3 in the matrix. We infer that some amount of this cargo must still reach the aECM independently of LPR-1, but it is then actively removed by SCAV-2, keeping its levels low. (C) In the absence of both LPR-1 and SCAV-2, cargo levels are restored to homeostasis and LPR-3 can assemble in the aECM.
Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity
Read this Research Article from our special issue #DevSIextracellular by @bellefeuille.bsky.social, Meera Sundaram & colleagues.
doi.org/10.1242/dev....
See the full issue here: journals.biologists.com/dev/issue/15...
Also in Issue 6:
🔹 2 Research Highlights on PDGF signalling and planarian innate immunity
🔹 Editorial on ‘Why is publishing so expensive?'
🔹 1 ‘Transitions in development’ interview
🔹 2 ‘People behind the papers’ interviews
🔹 Review on cell cycle control on plant development and reprogramming
Issue 6 is now complete!
On the cover: Fluorescence micrograph of a Caenorhabditis elegans gonadal region showing the spermatheca (cyan) and adjacent syncytial gonad (magenta). For more details, see Chan et al.
journals.biologists.com/dev/article/...
"Cell Cycle in Plant Development and Reprogramming”, @dev-journal.bsky.social W/ a fantastic ECR, Prof. Laura Lee @uncbiology.bsky.social! Artwork by Dr. Ramin Rahni. Thanks for the wonderful opportunity @texasscience.bsky.social @hhmi-science.bsky.social 🌱
journals.biologists.com/dev/article/...