Xin Lab Welcome! We study the cellular interactions between neurons and oligodendrocytes, which produce myelin in the central nervous system. Myelination - the process by which oligodendrocytes ensheath neuro...

Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto!

If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring!

www.oligodendrocyte.org

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Rescue of excitotoxicity in a mouse model of a rare neurodevelopmental disorder by ASO treatment.

How genetically encoded sensors have lit up neuroscience Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.

Thanks to @nature.com for featuring our work in this piece on genetically-encoded sensors.

The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin.

www.nature.com/articles/d41...

Cryo-EM maps of GluA2/TARP-γ2 (red) and GluA3/TARP-γ2 (green)

New research from @igreger.bsky.social group in the LMB’s Neurobiology Division, show that GluA3 adopts a structural organization that substantially diverges from all the other AMPA receptors.

Read more: www2.mrc-lmb.cam.ac.uk/architecture...

#LMBResearch

Congrats on this amazing work!

Excited to share our preprint: "A Cellular Basis for Heightened Gut Sensitivity in Females."
doi.org/10.1101/2025...

We address the question: Why do women feel more gut pain? We found that estrogen boosts communication between L-cells and EC cells, triggering increased gut sensitivity.

NIH cuts stalling progress on rare genetic disorders like SynGap1 Hopkins neuroscientist Richard Huganir is close to finding a potential life-changing treatment for kids with SYNGAP1-related disorders, but cuts to federal funding could delay or halt the progress

Here is an article about how NIH cuts are impacting research on rare genetic disorders like autism. hub.jhu.edu/2025/05/14/r...

Experts Call NIH Budget Cuts an 'Apocalypse' for Science The reductions target indirect costs that cover administrative and equipment costs.

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all.
time.com/7216299/nih-...

Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons - PubMed Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. Their morphology, connectivity, electrophysiological properties...

Beautiful example of spatial proteomic dissection
of synapse diversity from De Wit Lab!