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Research Fellow: Immune system and Cognitive function Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing & Alzheimer’s using iPSC models, genomics & molecular biology

Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing and Alzheimer’s, using iPSC models, genomics, and molecular biology @ukdri.ac.uk @dervissalih1.bsky.social Closing date: 26th June

www.dementiaresearcher.nihr.ac.uk/job/research...

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons Repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-associated non-AUG (RAN) t…

We tagged C9orf72 repeat dipeptides in patient iPSC-neurons and did genetic and small molecule screens with interesting results! Huge effort from many lab members @ukdri.ac.uk‬ @uclqsion.bsky.social and @alzheimersresearchuk.org‬ Drug Discovery Institute at UCL www.sciencedirect.com/science/arti...

A neuroprotective role of polyunsaturated fatty acids in C9orf72-ALS/FTD - Nature Neuroscience New research shows that lipid metabolism genes are downregulated in patient samples and Drosophila models of amyotrophic lateral sclerosis or frontotemporal dementia associated with expansions in C9or...

Great to see this news and views piece by @sandeepdubey.bsky.social and Hugo Bellen of our recently published work! @alexcammack.bsky.social @adrianisaacs.bsky.social @ukdri.ac.uk @ihaucl.bsky.social www.nature.com/articles/s41...

Thank you Nayanika! 😁❤️

Thank you Fabio!! 😁

Thank you Sarah!

Thank you Sara!

Thank you Selina!!

Thank you Darragh! 😁

Thank you to Alzheimer's Research UK and the Jean Corsan foundation for this incredible recognition! I am so grateful to ARUK for the continued support throughout my PhD and beyond!

Neuronal polyunsaturated fatty acids are protective in ALS/FTD Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...

Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
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