A third case where I would use it for optogenetic/chemogenetic tools is to describe the change in Kd between stimulated and unstimulated conditions...

It's weird to admit that I would use dynamic range in both cases, depending on the context!

Magnetic resonance control of spin-correlated radical pair dynamics in vivo - Nature Magnetic resonance control of spin-correlated radical pairs alters red fluorescent protein emission in transgenic Caenorhabditis elegans, demonstrating in vivo magnetic field modulation of biomolecula...

Quantum biological control, now in a multicellular organism!

Super exciting to see this work from @scburd.bsky.social et al 🧪

Wondering what's the difference between Halorhodopsin and Channelrhodopsin? Curious how a plant photosensor domain could power your next gene editing experiment? Check out our Optogenetics Guide to learn about these tools and more to light up your lab! 🧠💡🔬

Ribosome Molecular Aging Shapes Translation Dynamics
www.biorxiv.org/content/10.6...

daily #pokemon doodle 218 - #Slugma in a @beetlemoses.bsky.social style comic

Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday.

Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.

Our new paper just out!
pubs.acs.org/doi/10.1021/...

Quantum spin resonance in engineered proteins for multimodal sensing - Nature A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...

Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!

Huge thank you to the many many people involved in making this happen. 🧪

www.nature.com/articles/s41...

Just quit Quitting projects in science is hard, but we should be doing a lot more of it.

Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.

open.substack.com/pub/arjunraj...

Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.

Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!

#PhD #IMPRS #graduateprogram #maxplanck

Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"

www.janelia.org/content/lead...

An elegant sprite!

So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵

The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj

Reminds me of a guy I knew in grad school who filled out his NCAA bracket based on amino acid hydrophilicity (ignoring non AA letters). D(u)KE always did well :)

Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?

Turns out we can harness the power of bacteria to power the world’s smallest machines.

1/7 ⚛️🧪

Senior Director - Scientific Officer Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

Great Job - Great Colleagues - Great Science👍
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...

screenshots of some of the sample implementations

Screenshot of smartmicroscopy.github.io/implementations.html, showing an overview of collected implementation examples

Want to get started with smart microscopy? 🧠🔬
Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati...

More details in the ✨updated preprint!✨
www.biorxiv.org/content/10.1...

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

Congrats, Daniel!

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...

Very excited to be co-organizing this meeting next February. Fellow collective behavior enthusiasts, this one is for you!

Check out those figure making skills! She should do Illustrator tutorials.

On kid number 3 (kid 1 born in my last year as a postdoc) and this has been my weekend schedule for the better part of a decade :)

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

🤩Wow huge opportunity alert!

And for your Friday afternoon, some in vivo ERK and RTK biosensor eye candy :)

NIH will only accept six applications per PI per calendar year. NIH has issued NOT-OD-25-132 Supporting Fairness and Originality in NIH Research Applications which informs us that NIH will only accept six new, renewal, resubmission, or revision applications fro…

NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/n...