That RCT is underway by the same group… OBIRINS. Will be much more informative than OBI vs MMF.

clinicaltrials.gov/study/NCT057...

Comparative Efficacy of Nonsteroid Immunosuppressive Medications in Childhood Nephrotic Syndrome @aspneph @capneph #medsky #nephsky
https://buff.ly/4aC7NNn

Yet calcineurin inhibitor treatment was associated with more hospitalizations and IV albumin use, likely related to its nephrotoxic effects. Medication costs, local access, treatment duration, and side effect profiles should be considered when deciding between steroid-sparing meds in childhood NS

Comparative Efficacy of Nonsteroid Immunosuppressive Medications in Childhood Nephrotic Syndrome This study evaluates the comparative effectiveness of cyclophosphamide vs calcineurin inhibitors (tacrolimus or cyclosporine) for childhood nephrotic syndrome relapse prevention.

Excited to share our article today published in JAMA Pediatrics.

Using target trial emulation methods, we found no difference between cyclophosphamide vs calcineurin inhibitors for preventing childhood nephrotic syndrome relapses.

jamanetwork.com/journals/jam...

Half of all children with nephrotic syndrome are diagnosed or treated for hypertension.

Hypertension is more common in those with steroid resistance and frequent relapses.

BP should be monitored regularly in children with nephrotic syndrome!

www.jpeds.com/article/S002...

Prolonged remission after cyclophosphamide or tacrolimus treatment in childhood nephrotic syndrome: a cohort study - Pediatric Nephrology Background Steroid-sparing immunosuppression is used in 50% of children with nephrotic syndrome, to prevent relapses and steroid-related toxicity. However, rates and predictors of prolonged remission ...

Less than one-third of children with nephrotic syndrome achieve prolonged remission after cyclophosphamide or tacrolimus. Relapse rate before treatment is the strongest predictor of subsequent relapse.

Read our article published in Pediatric Nephrology: link.springer.com/article/10.1...

Use of 4% tetrasodium EDTA (KiteLock™) to prevent central venous catheter–related bloodstream infections in pediatric hemodialysis patients - Pediatric Nephrology Background Central venous catheter (CVC)–related bloodstream infections (CRBSI) are common in children receiving hemodialysis and cause significant morbidity and healthcare costs. Unlike standard lock...

Central line locking with 4% tetrasodium EDTA decreased CLABSI incidence by 79% in pediatric hemodialysis patients at our center.

Read our article published in Pediatric Nephrology to find out more! link.springer.com/article/10.1...

Welcome, #MedSky & #NephSky friends! 🌟 Since many of you are new here, I’m excited to highlight the importance of follow-up care for kids who’ve experienced #AKI - A crucial but underappreciated issue in paediatric nephrology! 🩺 this is a thread! #KidneyHealth #Paediatrics
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