2/2 which are often high ranking ones - have published papers they must know are complete nonsense, but neither the journals, nor the authors or methods promoters are actively helping in stemming the tide of this rubbish. For more on this see academic.oup.com/ije/article/...
Yet another spurious non-linear Mendelian randomization paper has been retracted by a journal academic.oup.com/jpubhealth/a... Kudos to the editors of the Journal of Public Health for following through and retracting spurious publications. What is shocking is that many other journals /cont
G-EE
A very much needed (and brilliant) reflection for Mendelian randomization
Have seen thousands of Velvets covers and also saw the Velvet Underground be their own tribute band on two unforgettable nights at Edinburgh playhouse June 1993, but think Waldo’s Gift at Ritual Union 2026 Bristol got closer to the VU spirit than any others I’ve seen
Blog by Andrew Elmore on the genotype-phenotype map reaource ieureka.blogs.bristol.ac.uk/2026/03/11/g...
🙏
🙏
I get confused and have to remind myself that despite my email address up till 2009 being zetkin@BLAH (depending where I was) this is Mel!
the principle for understanding genetic effects being that of gene-environment equivalence journals.plos.org/plosmedicine...
A comprehensive new tool for exploring how genetic variation influences outcomes, of relevance to everything driven by phenotypes, which encapsulates many domains, from how drugs work to how natural selection works ... / cont
Failure to understand that the fundamental principle of Mendelian randomization (MR) is of gene-environment equivalence contributes to the flood of nonsense MR papers that are appearing; Shah Ebrahim, Gib Hemani and I explain why in this short commentary. journals.plos.org/plosmedicine...
🤓There's an open 2 yr postdoc position in my group
🏘️ On interactions between area-level socioeconomic position and environmental factors in weight trajectories in children
📈 Using multilevel models; applying the target trial framework
📆 Apply before April 7th!
international.au.dk/about/profil...
Embarrasing correcton required for this - it was intended to say "gene-environment equivalence" not interaction is the fundamental principle of MR ..
Failure to understand that the fundamental principle of Mendelian randomization (MR) is of gene-environment equivalence contributes to the flood of nonsense MR papers that are appearing; Shah Ebrahim, Gib Hemani and I explain why in this short commentary. journals.plos.org/plosmedicine...
Failure to understand that the fundamental principle of Mendelian randomization (MR) is that of gene-environment interaction contributes to the flood of nonsense MR papers that are appearing; Shah Ebrahim, Gib Hemani and I explain why in this short commentary. Responses welcome!
Predictably enough, one of the people funded by Wellcome LEAP's FORM project is James B. Adams brainfoundation.org/brain-invest..., whose work featured in our recent review www.cell.com/neuron/fullt..., and not in a good way.
see wellcomeleap.org/form/
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
Great opportunity for a post-doc position with the amazing Luisia Zuccolo @humantechnopole.bsky.social Details here careers.humantechnopole.it/job/Postdoc-...
Can anyone now seriously deny that we’re living within the society of the spectacle? As foresighted in its way as Marx and Engels’ “all that is solid melts into air”
I never had you down as a situationist Darren ;-)
How the processes of recuperation vitiate apparent methodological advances in medical research, from meta-analysis to Mendelian randomization
Brilliant inaugural lecture by Professor Evie Stergiakouli on her career so far, @uob-ieu.bsky.social so lucky to have secured her talents right from its inception. Thx Evie!
“There is nothing that utterly destroys all chance for scientific investigation or any continuous work, like having a Distinguished Guest on your hands” H S Jennings, c1925
Perhaps counterintuitively higher prepubertal BMI is strongly protective against breast cancer in later life
Grace Power, @mendelrandom.bsky.social and others (not me!) takes a plausible causal FX of BMI on breast cancer, and narrow down *when* that effect plays out. They find the effects of later BMI on breast cancer are steeply attenuated when conditioned on early BMI. www.science.org/doi/10.1126/...
Newspaper headlines often share compelling quick fixes for health issues - but often the realities of what causes health conditions is more complex. In this blog post @mendelrandom.bsky.social explains why he encourages scientists to look for ways they might be wrong. www.ukri.org/blog/why-evi...
Even Confuseus has caught up on colliderscopes academic.oup.com/ije/article/... 🤣 @f2harrell.bsky.social @michelnivard.bsky.social
Happy New Year! To start the year, do read this @ukri.org interview with our director @mendelrandom.bsky.social, recipient of the prestigious MRC Millennium Medal. medium.com/@UKRI/why-co...
I know a bit about the past of MR, something about the present, and look forward to discussing whether MR has a future, and if so, how that should look
