Cool symposium in Paris💥💥💥👇

Evolutionary biology: what an aquatic microorganism can tell us about our distant origins Over a period of two to three billion years, the only living beings on Earth were single-celled organisms. In what conditions did living organisms with multiple cells emerge? How did life become more ...

Choanoflagellates — our closest animal relatives — form multicellular colonies in two ways: cell division AND aggregation.

This previously unknown "mixed multicellularity" suggests our animal origins are more complex than thought.

📄 @thibautbrunet.bsky.social ↘️

This is a FANTASTIC method to capture multilayer chromatin and gene regulation at allelic resolution(!!💥!!) on the same DNA molecule 🤩🥳🤩🥳
Well done @mpalamin.bsky.social and @arnaudkr.bsky.social 👏👏👏👏👏 - very beautiful work as always 💫💫💫!!

Thank you Christophe - and yes!! See you soon 😇

We have a dedicated freezer for ravioli di borragine in the lab 😅! Hope you pass by soon 😇

Thank you Nezha! 💫

Thank you Elisa!!! 🫶🫶🫶

Thank you Daan! I hope to see you soon 😊

Thank you Olga!! 💫

😉

Thank you Roberta!! We need to talk soon 😇😊💫!

Thank you Diana!! 🥳😊🥳!

Thank you so much Sergio!

Thank you Max! It’s good to be back 😎😇!

Thank you Juliane! 🥳💫

Thank you Edda!

Agnese LODA | Institut Imagine

I am also extremely grateful to the amazing colleagues and friends I've met along the way: thank you for your support and for all the fun to come! 💥

More about the lab: www.institutimagine.org/en/agnese-lo...

I would never be here without the incredible support of wonderful mentors: @joostgribnau, for his brilliant mind and constant encouragement and @heard65.bsky.social, for setting an inspiring example of scientific excellence, leadership and generosity.

The lab will also benefit from a secondary affiliation with the neighboring @devstempasteur.bsky.social

I feel honored to join such amazing communities of scientists and I am very grateful for the warm welcome.

I am very happy to share that I've started my new position @upcite.bsky.social and opened my lab @institutimagine.bsky.social 🎉

In the lab we will study how differences in X-linked gene dosage between the sexes affect fetal growth and survival and contribute to sex differences later in life 👩‍🔬🧪🧬🧫

Tomorrow I’ll be presenting at the 2026 CSHL Systems Biology meeting! 🧬

Join to hear about ChromSMF, a genomic method for integrated measurement of histone modifications, protein-DNA interactions, and DNA methylation on the same multi-kilobase DNA molecules! 🚀

Preprint coming soon 😉

The Institut Pasteur is pleased to invite you to the symposium Women’s Health, Women in Health, a one-day event to be held on 17 March 2026 at the Institut Pasteur, as part of the Month of Equality and International Women’s Rights Day. This event is part of the Pasteur Institute’s strategic plan, reflecting a shared commitment to scientific excellence through approaches that integrate the biological, social, and societal dimensions of health. In this spirit, the symposium will explore key challenges in women’s health through a multidisciplinary lens, at the crossroads of biomedical research, public health and social sciences, with a strong focus on sex- and gender-related issues. By bringing together biological, clinical, epidemiological and social perspectives, the event aims to foster dialogue on how such integration can refine research questions, strengthen knowledge production and better respond to health needs.

👩‍🔬 Women’s Health, Women in Health Symposium

Join us for a multidisciplinary event bridging biomedical research, public health, and social sciences. 🌍

🗓️ March 17, 2026
🔗 Register here: forms.office.com/Pages/Respon...
#WomenInHealth

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs - Nature Structural & Molecular Biology METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors ...

Tempted to add Metal gifs; that's how cool METALoci sounds!
In their recent article @natsmb.nature.com, @dariloops.bsky.social @mamartirenom.bsky.social @jrotwitguez.bsky.social @imotagom.bsky.social and colleagues shed light on sex-determining 3D regulatory hubs.
www.nature.com/articles/s41...

This is such a beautiful work, congratulations to all authors! 👏👏👏👏

Remodeling of XIST regulatory landscape during primate evolution How gene regulation strategies rapidly evolve across short evolutionary timescales is explored.

Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇

Congratulation Emmanuel, it’s a very cool story and I’m so happy to see it out! It was a lot of fun collaborating with you and the rest of the team - thank you 💫💫💫!!

Interested in transcriptional regulation, enhancers and 3D genome folding?

In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control

www.biorxiv.org/content/10.6...

detailed 🧵👇

SS18::SSX activates Polycomb target genes without BAF ❌
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social

XIST Drives X-Chromosome Inactivation and Safeguards Female Extraembryonic Cells in Humans Dosage compensation of sex chromosomes through X-chromosome inactivation (XCI) is required for mice extra-embryonic tissue growth and embryo development. The species specificity in mechanisms and timi...

𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐚𝐥𝐞𝐫𝐭! 🎉
“𝐗𝐈𝐒𝐓 𝐃𝐫𝐢𝐯𝐞𝐬 𝐗-𝐂𝐡𝐫𝐨𝐦𝐨𝐬𝐨𝐦𝐞 𝐈𝐧𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐒𝐚𝐟𝐞𝐠𝐮𝐚𝐫𝐝𝐬 𝐅𝐞𝐦𝐚𝐥𝐞 𝐄𝐱𝐭𝐫𝐚𝐞𝐦𝐛𝐫𝐲𝐨𝐧𝐢𝐜 𝐂𝐞𝐥𝐥𝐬 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧𝐬” 𝐢𝐬 𝐧𝐨𝐰 𝐨𝐧 𝐛𝐢𝐨𝐑𝐱𝐢𝐯!
www.biorxiv.org/content/10.1...

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!