Encouraging research into combination therapies for disease modification in #Parkinsons is the third pillar of our research strategy at @cureparkinsons.org.uk - click here to read more:
cureparkinsons.org.uk/research/res...
Last summer we had a workshop on this topic (a summary of the discussions will be published shortly) & at the end of last year we had an open funding call for research applications exploring rationally designed combos (more on that later!)
May be of interest:
@cureparkinsons.org.uk & collaborators have published an opinion piece on exploring combination therapies for #Parkinsons (including some hypothetical examples of possible combos) - we are looking for any & all feedback on this!
journals.sagepub.com/doi/10.1177/...
Many congrats to Glenda - thoroughly deserved! I was recently on a conference call in which she was giving everyone an amazing tutorial on a very specific region of the #Parkinsons brain. The kind of knowledge that comes from 10K hours. A master continuing to perfect her craft
We are excited to recognize renowned scientist Glenda Halliday, Ph.D., as the recipient of the 2026 Jay Van Andel Award for Outstanding Achievement in Parkinson’s Disease Research!
Read more: vai.org/gcpd-jva-awa...
There’s less than 48 hours left to vote for us in the Smiley Charity Film Awards! With your help, Cure Parkinson’s could win £3,000 (or more!) if our film ‘A Question of Time’ takes the top spot in our category. You have until Thursday 23 April to get your votes in!
Vote now: buff.ly/NPHWJ25
The "component is strongly correlated with disease progression in patients & prodromal symptoms suggestive of future development of PD" in both GBA-NMC & controls; These microbiome alterations similar in 3 independent cohorts from USA, Korea & Turkey (n=638 PD & 319 controls)
Combining clinical & fecal metagenomics of 271 #Parkinsons cases, 43 GBA1 non manifesting variants carriers & 150 controls, researchers report 25% of the gut microbiome in GBA-NMC is intermediate between healthy controls & PD patients
www.nature.com/articles/s41...
Using the Latin American Research consortium on the Genetics of #Parkinsons (LARGE-PD) dataset, researchers explore the revalence & associated clinical factors of levodopa-Induced dyskinesia in Latin America
journals.sagepub.com/doi/10.1177/...
Interesting: New research reports "MtDNA damage markers, particularly deletion burden, capture mitochondrial dysfunction arising from both genetic & environmental influences & are detectable across early clinical stages of #Parkinsons"
academic.oup.com/brain/advanc...
The SMART-PD (Self-Management, Remote monitoring & Timely review for #Parkinsons) study - semi-structured interviews with health care professionals working in the management and care of people with PD
journals.sagepub.com/doi/10.1177/...
My weekend read - new review on epigenetic biomarkers in neurodegen. conditions - everything from molecular signatures to therapeutic targets (#Parkinsons gets some mentions)
www.cell.com/trends/neuro...
Fbxo7-dependent neurodegeneration is not an irreversible process - new research presents a rAAV-Fbxo7 gene therapy approach that rescues the progressive nigrostriatal pathology in a mouse model of juvenile parkinsonism
link.springer.com/article/10.1...
A useful review on the molecular mechanisms of #Parkinsons-associated PINK1/Parkin-mediated mitochondrial quality control - from
www.cell.com/trends/bioch...
"The overall picture provided by this comprehensive review on the links between DYRK1A & #Parkinsons advocates for more fundamental studies to understand how DYRK1A participates to the onset & development of PD" - comprehensive is an understatement😳wow!
www.sciencedirect.com/science/arti...
New research finds DNA damage activates SARM1 to drive mitochondrial depolarization & axon loss; PARP1 hyperactivation engages SARM1 to execute neuronal parthanatos; SARM1 inhibition protects neurons in FUS-ALS, #Parkinsons, & excitotoxicity models
www.cell.com/neuron/fullt...
"By addressing these potential misconceptions, this review aims to set realistic expectations & highlight the true potential of dopamine cell therapy, fostering confidence & optimism for its future" - new review on cell transplantation in #Parkinsons
journals.sagepub.com/doi/10.1177/...
Researchers treating #Parkinsons patient neurons with myristic acid (C14:0) induces lipid metabolism modifications correcting abnormal PD-associated membrane composition & reversing PD-relevant phenotypes
www.nature.com/articles/s44...
"Plasma NfL elevation in iRBD supports its role as a marker of early neurodegeneration"; Its association with neurogenic orthostatic hypotension suggests it may identify a biologically more severe iRBD phenotype, possibly on a trajectory toward MSA
journals.sagepub.com/doi/10.1177/...
Tissue-specific mutation of #Parkinsons -associated Pink-1 jointly induces intestinal dysfunction & contributes to dopaminergic neuron degeneration
www.nature.com/articles/s41...
New data "support PRO-PD as a psychometrically robust outcome measure that can be completed remotely without trained administrators"
www.mdpi.com/2072-6643/18...
Single-nucleus brain transcriptomics on postmortem striatal brain tissue from 7 multiple system atrophy & 12 #Parkinsons patients (vs 10 non-neurological cases) reveals microglia expressing MHC class II HLA haplotypes in PD, suggesting a proinflam. state
www.nature.com/articles/s41...
A cross-sectional population-based analysis of The Australian #Parkinsons Genetics Study (APGS; 10,929 Australians living with PD) provides insights into risk factors, comorbidities, & sex differences
www.thelancet.com/journals/lan...
More data on clinical correlates of a negative cerebrospinal fluid α-synuclein seed amplification assay result in #Parkinsons; Negative participants had more severe axial motor impairment, lower odds of hyposmia, REM sleep behaviour disorder & constipation
www.nature.com/articles/s41...
Researchers report biochemically defined lysosomal dysfunction in Progressive Supranuclear Palsy; Show a pQTL effect of rs76904798 on CSF LRRK2 levels as well as baseline monocyte total LRRK2 levels predicting 1-year change in PSPRS scores
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Biognosys & The Michael J Fox Foundation have announced a partnership to develop #Parkinsons biomarkers; The partnership supports MJFF’s LRRK2 Investigative Therapeutics Exchange (LITE)
clpmag.com/lab-manageme...
A Cochrane review finds amyloid removal does not seem to be associated with clinically meaningful effects in people with mild cognitive impairment...Future "disease‐modifying treatments for #Alzheimers should focus on other mechanisms of action"
www.cochranelibrary.com/cdsr/doi/10....
New clinical trial registered: Lundbeck initiates a randomized, double-blind, parallel-group, placebo-controlled, flexible-dose trial of Lu AF28996 (dual dopamine D1 & D2 receptor agonist) in 150 adults with #Parkinsons experiencing motor fluctuations
clinicaltrials.gov/study/NCT075...
Bial launches “Dialogues with #Parkinsons” – a year-long awareness & education campaign designed to support clearer communication between people living with PD, their carers & healthcare professionals. Developed with @parkinsonseurope.bsky.social
www.bial.com/en/media/new...
