📢PUBLISHED @natgenet.nature.com

📰Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks.

By Ching-Huang Ho, John P. Ray and colleagues.

⬇️

www.nature.com/articles/s41...

Congrats to the first author, Alex (Ching-Huang) Ho from my lab, and thanks so much to all of our important collaborators, including @tewhey.bsky.social @mgoguo.bsky.social @carldeboer.bsky.social @jshendure.bsky.social and many others.

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Transgenic means that genes from 1 organism have been put into another. We make transgenic mice to understand how genes influence biological processes. We make transgenic plants to make them more nutrient rich. We make transgenic bacteria so they make medicine for us. It's wide-ranging & v. useful.

Seattle scientists protest Trump's medical funding freeze, warn of research impacts Biomedical research is teetering on a crisis after President Donald Trump held up the grant money that helps fund the industry, pending a review of all federal

I ❤️ UW Immunology. Thank you @jmoltke.bsky.social.

komonews.com/news/local/t...

This is what amounts to an ILLEGAL & indiscriminate funding cut for research centers everywhere. It will mean shuttering labs across the country, layoffs in red & blue states, and derailing lifesaving research on everything from cancer to opioid addiction.

We all need to speak out to save lives.

My weekend with immunologists devising new strategies to treat cancer, allergy, Alzheimer’s, autoimmunity and infection. The WH has just paused peer-reviewed NIH funding that pays for these studies. If you care about human life, write your representatives. Demand that NIH funding is restored asap.