Could the bar be any lower?

Irish skin is basically not fit for purpose. I speak as someone covered in it.

We already KNOW how to make super babies, you eugenicist creeps! And it's all the things you fucking fucks are fucking up! THREAD!

Massive Attack, Tom Waits - Boots on the Ground YouTube video by Massive Attack

Tom Waits is back.

Massive Attack are back.

A song for our times.

Bleak.

youtu.be/L-57FrioeuE

There are other variants?

Attarazat Addahabia & Faradjallah — Al Hadaoui | The Quietus Re-connecting American blues music with its West African ancestry has become a well trodden path. The infectious beats of John Lee Hooker’s guitar licks are clearly present in the work of the legendar...

Fourteen members of the Faradjallah family.

thequietus.com/quietus-revi...

Attarazat Addahabia & Faradjallahالترزات الذهبية و فرج الله - Aflana ا​ف​ل​ا​ن​ة (1972) YouTube video by Kate Yelkovan

I heard this on Young Sherlock, I had to stop the program to find the source of this music.

Couldn't be more obscure -- 1970s-era Moroccan family band.

Crazily brilliant, riffs on Beethoven's Für Elise like nothing you've heard before.

youtu.be/5P4QdbwHzZ0?...

This @anshulkundaje.bsky.social, Kyle Fahr and William Greenleaf paper is finally out, we've been following it for a while in its preprint form, phenomenal work.

www.nature.com/articles/s41...

The Human Genome Project left 98.8% of the genome uninterpretable. It's time to shed light on the dark genome so we can provide answers for families with rare diseases. Sticking with current approaches will not solve this problem.

The accessibility of and ability to perform functional testing on blood/immune cells makes this field of rare diseases especially suitable for the development of rare disease diagnostics.

In Figure 2 we describe how we would propose triaging non-coding variants (NCVs), as a step towards generating evidence supporting pathogenicity and disease causation, currently not addressed in clinical genomic diagnostics.

Grateful to have the opportunity to publish this review with Xiao Peng in Annual Reviews. We set out the challenges and opportunities to use information in rare disease diagnostics from the 98.8% of the human genome that does not encode genes.

www.annualreviews.org/content/jour...

Oh it’s all in there. Lots of Waddington.

Cardi B, Bronx native, one of my favourite people.

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

"Only 20 left in stock" for my book on Amazon -- that's kind of gratifying. And thanks to the two lovely people who rated the book 5 stars.

a.co/d/09cT0Y4C

Today, I'm introducing my wealth tax — and more than 50 members of Congress are joining me. It’s time for the government to start working for American families, not just the ultra-rich.

Today, I'm introducing my wealth tax — and more than 50 members of Congress are joining me.

It’s time for the government to start working for American families, not just the ultra-rich.

Good on you Tuuli

I feel your pain

A deep dive without first defining what they mean by #epigenetics.

But that's OK, nice thought-provoking ideas.

Gedankenexperiment: if you replace the word "epigenetics" throughout with "transcriptional regulation", now how does it look?

Thanks for these perspectives Shai. Sorry you’re having to go through this.

Gene-environment equivalence: The fundamental principle of Mendelian randomization In this Perspective, George Davey Smith and colleagues outline how and why gene-environment equivalence, the fundamental principle of Mendelian Randomization (MR), must be properly applied and critica...

Failure to understand that the fundamental principle of Mendelian randomization (MR) is of gene-environment equivalence contributes to the flood of nonsense MR papers that are appearing; Shah Ebrahim, Gib Hemani and I explain why in this short commentary. journals.plos.org/plosmedicine...

Happy St. Patrick's Day, New York.

Lá Fheile Pádraig sona daoibh!

Today we emigrants celebrate our Irish pride.

I am involved in the New York Celtic Medical Society. Founded in 1891, it was a way for Irish doctors to counter anti-Catholic bias in #NYC.

Now we exist to pay our good fortune forward.
www.celticmedsocnyc.org

Sail Óg Rua - Album by Dolores Keane Listen to Sail Óg Rua by Dolores Keane and John Faulkner on YouTube Music - a dedicated music app with official songs, music videos, remixes, covers, and more.

Sad to hear of the passing of the great Dolores Keane.

I will have this on repeat tomorrow in celebration of what she has left us.

music.youtube.com/playlist?lis...

Looks like a tin-eared response, unhelpful, especially the part that comes across as blaming the victims.

Confidential health records from UK BioBank project exposed online Exclusive: Guardian investigation finds data from flagship medical research leaked dozens of times

We need to move on from the era of extractive population genetics.

The model needs to start benefiting study participants, with data privacy the *bare minimum* as a deliverable.

www.theguardian.com/science/2026...

Chief Executive Officer - New York City, New York (US) job with arXiv | 37961678 arXiv seeks its first CEO to champion open, free scientific discovery and guide the platform’s next chapter as an independent nonprofit.

arXiv to spin out as an independent non-profit. They are seeking a CEO jobs.chronicle.com/job/37961678...

lt 1500m olympic final 1956 YouTube video by ImageDesign Publishing

RIP Irish athletic hero Ronnie Delany

Very odd running style but it got him a gold Olympic medal

youtu.be/u696YRFCfFg

Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial - Nature Medicine In a prespecified ancillary analysis of the COSMOS randomized trial, supplementation with daily multivitamins, but not with cocoa extract, over the course of 2 years decreased biological aging, as mea...

Unusual to see serial measurements of epigenetic ageing clocks.

But then the problems arise: multiple clocks, a choice of age versus acceleration, no real biological hypothesis or way of interpreting the meaning of the results.

I don't see the value of these studies.
www.nature.com/articles/s41...