Applied to humans, we identify e.g. a human lineage expanding ~50kya outside & within Africa and a much deeper event between two hominin groups impacting Neanderthals & ancestral modern humans; remarkably the two predominant PRDM9 alleles in humans today evolved separately in each of these groups!
Individuals are modelled as mixtures of (ghost) ancestors and we simultaneously infer their local ancestry contributions. Additionally, we propose looking at "types of mutations" in each of the ancestry segments, which is not used in GhostBuster, to provide independent evidence for these events.
New preprint led by Hrushikesh Loya, me, and Simon Myers where we introduce GhostBuster! www.biorxiv.org/content/10.6...
The idea is to find all the different ways a target individual relates to reference groups in genealogies, to "bust the ghosts" in our ancestry.
Very honoured and I owe a lot to all my mentors and colleagues, thank you!
New ad for an independent postdoc in mathematics/statistics/machine learning for Biology in my institute at RIKEN (not my lab), ranging from 3 to 7 years. Our institute is entirely English-run, and a good mix of expertise on maths/physics/stats/bio! www.riken.jp/en/careers/r...
Postdoc position in my group in Tokyo!
Please get in touch if you are interested.
And happy to discuss projects - these would range from developing new methods to analysis of new genomes that we are now sequencing in the lab.
Job Ad: www.riken.jp/en/careers/r...
Lab page: speidellab.github.io
A 4-year postdoc position in population genomics is available in my group at the University of East Anglia, to work on a project sequencing a thousand fox genomes across rural and urban environments in the UK.
vacancies.uea.ac.uk/vacancies/15...
Our review of recent Sequentially Markovian Coalescent methods is up on arXiv: arxiv.org/abs/2506.00692 (based on last year's @official-smbe.bsky.social symposium)
🧵1/n ✨🔮✨ Meet (y)our instructors of this year's #HAAMsummerschool 👇 #aDNA #course #humanpopgen
I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.
Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
Our @ucl.ac.uk @crick.ac.uk work, out this week in @science.org, traces a genetic time series of bacterial infections to reveal when and how Borrelia recurrentis jumped from ticks to humans—via our body lice.
www.science.org/doi/10.1126/...
Our new paper is out in @science.org! By exploring the rich genetic diversity of Brazil, we show how fine-scale genomic analyses reveal that this diversity, rooted in Indigenous ancestry and centuries of complex demographic history, plays a key role in population health.
Our paper on ancient human population structure is now published. We find that the ancestors of modern humans lived in multiple populations during the period when Homo sapiens evolved in Africa. www.nature.com/articles/s41...
We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/
Thread and open access version to come-
Ancient genomics and the origin, dispersal, and development of domestic sheep | Science search.app/gtSKYHF5HqRa...
#adna
I posted a couple days ago about our new paper on building causal graphs from genetic associations + Perturb-seq.
Here I want to expand on the value of using DIRECTIONAL information contained in LoF burden tests.🧵
[work led by @minetoota.bsky.social ]
bsky.app/profile/jkpr...
📢📢📢 #SMBE2025 Abstract Submission EXTENDED to Saturday, February 15, 2025
We also invite you to register at www.smbe2025.org
@SMBEmeetings
Excited to share our preprint "A putative ecocline in Klebsiella pneumoniae" and super-interested to get your feedback. Really want to use the hive mind to get to the bottom of this phenomenon ASAP. www.biorxiv.org/content/10.1...
My bluesky debut!
One week to the submission deadline for SMBE 2025, Beijing 20-24 July smbe2025.scimeeting.cn
@anaignatieva.bsky.social and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.
