Thanks Anitha for all your contributions to LIBERATE-D!

#NephJC Thank you for featuring LIBERATED-D. Happy holidays everyone.

#NephJC We agree but it appears some nephrologists are already doing mostly ‘conservative dialysis’ in AKI-D.

#NephJC Yes. Ours was not designed as a non-inferiority trial, but one can take your interpretation.

#NephJC and in both ATN and Schiffl
trials, 3/wk was the control arm (vs 6/wk)

#NephJC KDIGO recommend still 3/wk HD with 1.3 delivered Kt/V in AKI.

#NephJC the editorialist wondered if our control arm represented ‘unnecessary dialysis’ and was not ‘standard of care’—sounds like many at #NephJC do not feel the same way?

#NephJC in AKIKI-2 BUN of 140 seemed too late/associated with harm, so there is some signal

#NephJC Yes and median (IQR) serum creatinine was 4.4 (2.9-6.7) mg/dL (despite receiving dialysis up until then)

#NephJC The traditional approach is increase in native renal function and then dialysis cessation. We proposes a different paradigm: dialysis cessation to promote increase in native renal function.

#NephJC it is only after 14 days that we know GFR has recovered enough that we go back and identity ‘1st day of recovery.’ We think some have misunderstood the curves to think we were providing unnecessary dialysis in the control arm at time of randomization.

#NephJC it is important to point out that ‘1st day of recovery’ was defined retrospective. On that day, GFR may be very low (so not ‘recovered’ in the way many people use the word). See 2 figures below for illustration. Both these patients contributed to those Kaplan-Meier curves separating early.

#NephJC those are based on the AKIKI ‘late start’ triggers, we basically took the same triggers and said not to continue HD unless we hit the same triggers, it was safe in AKIKI

#NephJC standard

#NephJC This is Chi Hsu, senior author and one of the two PI’s for LIBERATE-D. Thanks for choosing our paper. I am borrowing UCSF Nephrology Division’s BlueSky account.

Proud to introduce our incoming class of UCSF Nephrology fellows. What a phenomenal match!!

Congratulations to Dr. Cynthia Delgado for getting her R01DK140948 titled “Contributions of Volume Overload Level and Ultrafiltration to Morbidity in ESKD."

Continued newsletter with more amazing work!

ASN Kidney Week 2025 is here!! Stop by and check out the great work by UCSF faculty, fellows, and affiliates!

The wait is almost over. #KidneyWk begins Wednesday, November 5, with seven Early Programs, then continues November 6–9 with the Annual Meeting in Houston, 12,000+ kidney health professionals. 130 sessions. 600 faculty. 3,600 posters. Four dynamic plenaries. The future of kidney care begins here.

Our faculty member, Dr. Kathleen Liu, will be the keynote speaker at the 5th International Symposium on AKI in Children!

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$2 in economic activity is generated for every $1 the federal government invests in science. Science spending pays off.

Tell Congress: Investing in science leads to a stronger America #SpeakUp4Science https://bit.ly/4mgBMQ9

Congrats to Dr. Uchenna Nwosu for receiving the Excellence in Teaching Award!

The award is peer-nominated to highlight outstanding front-line teachers of learners, mentors of learners, and faculty at all UCSF teaching sites for the 2024-25 academic year.
meded.ucsf.edu/faculty-educ...

CONGRATS to our faculty, Dr. Meyeon Park, on your Excellence in Teaching Award! VERY well-deserved! 😊

meded.ucsf.edu/faculty-educ...

Congratulations to Dr. Harini Sarathy on being inducted into the Haile T. Debas Academy of Medical Educators for excellence in direct teaching to medical learners at all levels of training and curriculum development for our nephrology fellows!

“As a public university, we are stewards of taxpayer resources, and a payment of this scale would completely devastate our country’s greatest public university system as well as inflict great harm on our students and all Californians.” —UC President James B. Milliken

The federal government’s demand of $1 billion from @UCLA would devastate the nation’s best public university, cut off life-saving care, halt tech and economic growth and reduce educational access.

Stand with UC to protect our vital mission: www.universityofcalifornia.edu/get-involved...

Complex Etiologies of the Discordance Between Cystatin C– and Creatinine-Based Estimated GFR and Its Adverse Associations: Findings From the CRIC Study

bit.ly/McCoyOI25

Dr Ian McCoy and Chi-yuan Hsu’s paper in @ajkd.bsky.social selected y @nephjc.bsky.social for discussion.

The University of California is the country’s best value in education, new rankings show Princeton Review and Money agree: UC campuses offer a stellar mix of academics, affordability and student outcomes, according to their newly issued annual lists.

@theprincetonreview.bsky.social and @moneymag.bsky.social
agree: The University of California offers the best educational value in the United States, according to their newly issued annual lists. www.universityofcalifornia.edu/news/univers...