Congrats to Jonas! Not satisfied with working only on replication, he’s bagged himself a paper on bacterial translation 🙃

www.nature.com/articles/s41...

Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.

Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Supervisors and Projects

An enormous thanks to @wellcometrust and everyone who’s helped along the way

📢 PhD position open now 🎓– apply here 👉
www.bioch.ox.ac.uk/supervisors-...

🧪 Postdoc adverts coming 2026!

From autumn 2026, we’ll be exploring how transcription–replication conflicts impact genome stability using cryo-EM, biochemistry, and single-molecule methods 🔬

I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉

Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome | The EMBO Journal imageimageCtf18-RFC is a dedicated leading-strand replication clamp loader, with RFC unable to fulfil this role. This study provides a mechanistic basis as to why this is the case and reveals unique f...

Great new work from the very talented Emma Fletcher (@Yeeles_Lab). Biochemistry, and a touch of cryoEM, reveal why the DNA replication machinery needs a dedicated leading strand PCNA clamp loader. 🧬🧪🥼🔬🧑‍🔬

www.embopress.org/doi/full/10....