Hollow Body - Longreads On attention to craft in defiance of AI.

Very inspiring essay! longreads.com/2026/03/26/c...

Fleetwood Mac - Go Your Own Way [Cover by Mary Spender] YouTube video by Mary Spender

Your moment of Zen
www.youtube.com/watch?v=BxSL...

Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...

Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Sam Wang, Politician-in-Training The neuroscientist went from analyzing elections to running for Congress. But can this rookie win over New Jersey locals—and Trump voters?

Dog walks and people on the street: a New Yorker writer sees what it's like for a scientist to run for office.

New: www.newyorker.com/magazine/202...

Child Safety Strap Locks (4 Pack) Baby Locks for Cabinets and Drawers, Toilet, Fridge & More. 3M Adhesive Pads. Easy Installation, No Drilling Required, White/Gray Amazon.com: Child Safety Strap Locks (4 Pack) Baby Locks for Cabinets and Drawers, Toilet, Fridge & More. 3M Adhesive Pads. Easy Installation, No Drilling Required, White/Gray : Baby

Also good for keeping those pesky 4 / -20 deg doors closed!

www.amazon.com/Cabinets-Adh...

Data. A mouse model of glioblastoma leads to inevitable death within 50 days. Delivery of HSV+TK plus IL2, driven by a strong and specific synthetic superenhancer, allows almost all mice to survive even after nearly 150 days. From Fig5 of Koeber et al 2026

Just look at this graph (Fig 5A,B from Koeber et al).

Amazing.

Congratulations to the Pollard lab and all authors.

www.nature.com/articles/s41...

Radical Black Women of Harlem – The Municipal Art Society of New York We’ll visit the street corners, buildings, public places and neighborhood spots where Black women made history – with impacts that extended far beyond Harlem’s streets to the world.

Happy Friday. Registration for Jane's Walk NYC is now open. I will be once again facilitating a walking tour as part of the festival. I am offering an abridged version of our Radical Black Women of Harlem tour on May 2 at 11 am - www.mas.org/events/radic... - Registration is free. Don't placehold.

Do it! The magnolias are in bloom, the sun is shining, the birds are chirping, and traffic noise at the Queens Midtown Tunnel is pretty low-key at the moment 😝

The gradient of heights from the angle of the bike rack leading to the people and the sun in the lower right photo is spectacular. Really inspiring composition there.

Form follows function, or function dictates form?

📢Preprint: we build Perturb-CLEAR, in vivo screen of neuroanatomy! Disease perturbations produce selective morphology-RNA changes that RNA impact alone cannot predict. Was led by the invincible grad student Boli Wu!

www.biorxiv.org/content/10.6...

The soups! So good for what ailed ya.

You won't believe it, but CoComelon numbers don't lie. A most hopeful take on the statistics of the world's attention in this thread.

Fantastic news! They are lucky to have you.

Had to much fun working on this project with Kelsey and the Hoekstra lab. A project born after Hopi gave a talk at Janelia may years ago

Some extra(ocular)-ordinary work from the Schoppik Lab 🔥 🧪

A WHOLE CIVILIZATION WILL DIE TONIGHT My son needs lunch, and I have to put his backpack together, but a whole civilization will die tonight, so I'm wondering if they've closed their schools. Like, a snow day, maybe, except instead of snow it's "keep your children home so if you die, you die together" — instead of "well open back up once the plows have cleared" it's "we don't know if we'll be here tomorrow, hold your babies tight." It's just "talk" I'm told, which I've been told before. "It's how the president makes his deals." But I've never heard anyone talk about other human beings this way, and I'm not certain I can look my son in the eyes if we all agree to stomach it one more time. A civilization will die tonight, but as I zip up his backpack and kiss him off to school I think: if this is what we call leadership then I'm not entirely sure ours isn't already dead. @michaelfdubois Mukad A QuBoy @michacifdubois

Brutal.

A graph of eye velocity versus time that establishes that fish with loss of function mutations in the phox2a gene can't move their eyes when tilted.

An image showing expression of a particular gene in the motor neurons that move the eyes. Black spots show where the gene is expressed, dotted lines outline the cranial motor nucleus nIV that contains motor neurons that move the eyes up

The top shows a schematic of a fish with motor neurons marked in green and a pipette used to suction motor neurons for later analysis. The bottom left shows white dots that mark each motor neuron; the bottom right shows no white dots to indicate the motor neurons had been selectively removed for later analysis.

Our new work goes from genes to behavior to understand the molecular underpinnings of the most common childhood disorder of vision: strabismus. Led by UCSF-bound Emily Gershowitz & Kyla Hamling, plus rockstars
@denagoldblatt.bsky.social & @paigel.bsky.social
www.biorxiv.org/content/10.6...

www.biorxiv.org/content/10.6... thx MN

www.biorxiv.org/content/10.6... thx DB

www.biorxiv.org/content/10.6... and @paigel.bsky.social is the right Paige it's gonna be that kind of day.

a joyful golden retriever mid-sprint through green grass under a canopy of pink cherry blossoms

i feel like you all need this

Well Lord knows you'll find "that guy" on here 😝

Ravenous Is a New Worker-Owned Food Culture Media Company For too long, food media has felt toothless. Help us take a bite out of it.

Today, my fellow founding worker-owners and I are launching a subscription drive to @feedravenous.bsky.social. We are a group of experienced and award-winning food journalists here to publish thoughtful writing and incisive reporting from around the food world.
www.weareravenous.com

LOL typical middle-aged scientist man's midlife crisis response to a CNS rejection 😁

Came here to say that -- @senguptalab.bsky.social is there a reason eNeuro doesn't do it for you?

A long, skinny map titled: "Life and Travels of the European Eel" with a subtitle reading: "From the Eel's Perspective." A label at the bottom of the map reads: "Begin Here." The map top half of the map is an mirror copy of the bottom half. I will put the full text of the column in the alt text in an image in the next post in the thread. The map goes from the bottom of the page up, starting in the Sargasso Sea. An set of arrows show the eels paths to shore, then up a river and into a marshland. The arrows continue up the page to show the eel leaving the marshland and heading back downstream, and out to sea. The land is green and verdant at the bottom of the map, because the eels migrate upstream in the spring. The land is brown and dry at the top of the map, because eels migrate downstream in the autumn. A column of text on the side tells about the eels' journeys and changes. It is more text than I can relate in the space allowed here. Each paragraph has an arrow pointing up to the next one, and they are designed to be read from the bottom of the page going upwards.

Several years ago, on a whim, I started drawing a map of an eel's life travels as seen by the eel.

I figured an eel thinks about its life as a linear journey, rather than a there-and-back again adventure. So I wanted to do a map to reflect this.

This morning, on another whim, I finished the map!

Good books in the replies to this tweet

Excited to share our new J Neurosci paper showing how subcortical inputs are routed through ventromedial (VM) thalamus to layer 1 interneurons in the medial PFC, all done by my graduate student Sanne Casello:
sannemcasello.bsky.social
www.jneurosci.org/content/earl...

A beautiful short film: www.nowness.com/series/poeti...