- Checkpoint signaling slows down replication in response to Top1 poisoning by camptothecin. - Checkpoint signaling is actively dampened by Slx4 and Fun30 to permit Exo1-dependent resection of replication forks. - Checkpoint dampening is critical to promote replication fork protection and preserve genome stability.

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

FEBS Press DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...

Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...

FEBS Press DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...

Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...

ATM controls Golgi morphology

ATM controls Golgi morphology

ATM controls Golgi morphology

ATM controls Golgi morphology

When DNA damage responders are not only that: @MorieLAB.bsky.social shows that, without ATM, one master kinase responding to DNA damage, the Golgi is markedly deployed. ATM phosphorylates Golgi substrates to limit Golgi extension, which matters for Golgi cargo maturation: doi.org/10.64898/202...

When DNA damage responders are not only that: @MorieLAB.bsky.social shows that, without ATM, one master kinase responding to DNA damage, the Golgi is markedly deployed. ATM phosphorylates Golgi substrates to limit Golgi extension, which matters for Golgi cargo maturation: doi.org/10.64898/202...

Very important work, we should care much more about resistance to antibiotics…

Visit our fully accessible journal archive, providing perpetual access to 34k articles from over a century of pioneering research in developmental biology, cell biology, comparative physiology and biomechanics, including work from 60+ Nobel Prize-winners bit.ly/3PfIjib

The application deadline for the 20th FEBS/EMBO Spetses meeting is extended to the 15th March! Please sign up at the link below, or encourage your PhDs and postdocs to come along for what is certain to be a wonderful week!

Bravo, Joe. What a satisfaction! Now, ready to build on all your achievements with wisdom and serenity ❤️

The greatest opportunity. Do not self-censor! Try!!

Happy to share our new paper in @febsj.bsky.social! With
@ondrej-kuda.bsky.social & @fedorovalab.bsky.social we show how #LipidDroplets reshape the lipidome of PUFA-exposed cells, but can also shift function within the same cell, revealing a context-dependent role in #ferroptosis. shorturl.at/TyRl1

Only one month left to apply!! Remember: CRBM = Good & Happy Science

It’s finally out! Together with @embopress.org and
@reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

Read this @emboreports.org paper here=> link.springer.com/article/10.1...

Thanks so much for highlighting our study! The tool is versatile and ready to uncover so much new knowledge 😀

Want to organise one of our Workshops? You focus on the science, we focus on the logistics. Next deadline for topic proposals: 29 May 2026 The Company of Biologists icon to the left, two people discussing outside to the right

Do you have a vision for a Workshop but don’t have the time to arrange the logistics or raise the funding? Submit your idea to us in our annual call for topics. We'll provide all necessary support for successful applications. Find out more at biologists.com/workshops/pr...

The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders - FocalPlane The Centre for Research in Cellular Biology of Montpellier (CRBM) is recruiting Junior / Senior Group Leaders to shape its research in the coming decade

The Centre for Research in Cellular Biology of Montpellier @crbm-montpellier.bsky.social is recruiting Junior/Senior Group Leaders.
Check out the details on our cell biology jobs board: focalplane.biologists.com/cell-biology...

Figure showing AXL activation regulates stiffness-dependent Golgi organization and cell spreading in MDA-MB-231 cells.

Arnav Saha, Tushar Sherkhane and Nagaraj Balasubramania uncover a mechanosensitive pathway linking ECM stiffness to Golgi organisation and function in breast cancer cells.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Sounds like a dream place for any cell biologist!

Please REPOST (“likes” don’t help in diffusion!) and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization.

www.biorxiv.org/content/10.6...

Our journals @dev-journal.bsky.social, @jcellsci.bsky.social & @jexpbiol.bsky.social offer Travelling Fellowships of up to £3,000 to graduate students and post-doctoral researchers wishing to make collaborative visits to other laboratories. Apply by 6 February 2026.
biologists.com/grants/trave...

🤣🤣🤣 we know each other well now: I knew you would appreciate!

VAPA at the Inner Nuclear Membrane, impacting lamins, modulating the formation of nucleoplasmic reticulum and… affecting histone acetylation… perhaps lipids and chromatin happen to be related? 😁

The Tyler Prize for Environmental Achievement names Toby Kiers as the 2026 Laureate.

Her research reveals how underground fungal networks support life on Earth.

Explore the hidden world beneath our feet:
tylerprize.org/laureates/toby-kiers
spun.earth/underground-atlas
@spun.earth

Another pine pollen for #FluorescenceFriday! It seems that this year too, I still won't get tired of colour coding my microscopy 🧡💜💙💚❤️

Super-fun, absolutely WONDERFUL paper from Gohta Goshima

www.nature.com/articles/s41...