Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...

New paper alert 🚨
We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us!
Tweetorial in comments 🧵
www.nature.com/articles/s41...

The extracellular matrix in cancer: from understanding to targeting Significant advances in matrix biology research have enhanced our understanding of individual matrix components and extracellular matrix (ECM) signall…

New review paper written by Jess Chitty in the team just out in Trends in Cancer (@cp-trendscancer.bsky.social) (OpenAccess)
The extracellular matrix in cancer: from understanding to targeting
| → www.sciencedirect.com/science/arti... ← |

Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response Temporal mass spectrometry proteomics, advanced microscopy, and in vivo modeling reveal nidogen-2 as a cotarget in PDAC.

Congratulations to @mbsanz.bsky.social MCR Paper of the Year 2024 Recipients, Brooke Pereira & Shona Ritchie, (co-led by @tcox.bsky.social ), for their latest work looking at the role of Nidogen-2 in pancreatic cancer published in Science Advances!

www.science.org/doi/10.1126/...

Targeting the NPY/NPY1R signaling axis in mutant p53–dependent pancreatic cancer impairs metastasis Targeting NPY1R reduces mutant p53–dependent pancreatic cancer metastasis.

Excited to kick off my Bluesky posting by sharing this work by the lab looking at the role of neuropeptideY in #pancreaticcancer metastasis. An amazing piece of work and so thrilled to see it finally out!

@garvaninstitute.bsky.social

www.science.org/doi/10.1126/...