A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice Stress-recruited neurons can cause anxiety-like avoidance and increase peripheral corticosterone concentration.

❗❗Honored to be cited in eLife
👏👏Prof. Jing Han’ team Uncovers Neural Circuit Mechanisms Underlying Anxiety-like Behaviors.
Brain_VTA offers AAV packaging services.
BrainVTA website: www.brainvta.tech
elifesciences.org/articles/108...

Astrocyte cell volume dynamics across cortical states and transitions Deng et al. used in vivo two-photon imaging to characterize sleep-wake-dependent changes in astrocyte volume. Using chemogenetic and optogenetic activation of locus coeruleus tyrosine hydroxylase-posi...

❗❗NEWS︱Neuron
👏👏Prof. Fengfei Ding’s Team Uncovers the Mechanisms of Cortical Astrocyte Volume Regulation During Sleep-Wake State Transitions.
BrainVTA website: www.brainvta.tech
MORE
www.cell.com/neuron/abstr...

❗❗Honored to be cited in Nature Communications
👏👏Prof. Zhong Chen’ team Uncovers the Mechanism by Which the Perirhinal Cortex–Hippocampal Gray Zone Circuit Regulates Temporal Lobe Seizures.
@Brain_VTA offers AAV packaging services.
BrainVTA website: www.brainvta.tech
www.nature.com/articles/s41...

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

The neural mechanisms supporting the rise and fall of maternal aggression - Nature In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during lactation.

What has changed in mama bear brain (well, actually mice) to make her risk her life to attack a potential threat and protect her young? Oxytocin is the key! Happy to share our new study led by two awesome postdocs: Takashi Yamaguchi and Rongzhen Yan.
www.nature.com/articles/s41...

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. ...

Honored to be cited in
Prof. Cheng Xiao’ team Reveals How the Substantia Nigra–Subthalamic Nucleus Dopaminergic Pathway Regulates and Characterizes Specific Pain Patterns Under Physiological and Pathological Conditions.
@Brain_VTA offers AAV services
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol - Nature Neuroscience This study uncovers how amyloid-β boosts astrocyte calcium activity, increasing cholesterol and disrupting brain waste clearance in an Alzheimer’s disease mouse model. Targeting astrocyte calcium or c...

❗NEWS︱Nature Neuroscience
👏New Breakthrough! Prof. Yamei Tang’s Team Uncovers a Novel Mechanism by Which Astrocytes Regulate Lymphatic-like Function in Alzheimer’s Disease.
BrainVTA website: www.brainvta.tech
👇MORE
www.nature.com/articles/s41...

❗New research tool spotlight 🔬: Introducing recombinant adenovirus Ad-TSHR289, a gold-standard tool for modeling Graves' Disease (GD) in animals. Efficiently expresses the human TSHR A-subunit, induces robust TSAb production & GD pathology. Perfect for mechanistic & drug discovery studies. 🧪

One of our favorite movies on NE dynamics in Visual Cortex - Using nlightG2 we found NE transients to be highly structured both in space and time

UK Glia 2026 UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...

This meeting looks like its going to be bigger and better than 2024.

Come to Bristol in June for the chance to mingle with the glia glitterati of the United Kingdom

#neuroscience #glia #science #events #conference #networking

www.physoc.org/events/uk-gl...

The gut microbiota alleviates depression by remodeling gut-brain energy metabolism Lu et al. employ a multi-omics approach to profile systemic metabolism and gut microbiome signatures in depression and reveal that microbiome-dependent host imbalance of energy metabolism mediated by ...

❗ Honored to be cited in Cell Metabolism
👏 Prof. Xiong Cao’ team Identifies New Therapeutic Target for Depression.
Brain_VTA offers AAV and lentivirus packaging services.
BrainVTA website: www.brainvta.tech
www.cell.com/cell-metabol...

Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse - Nature Communications Social rewards hold therapeutic potential for alleviating drug relapse, yet the neural substrates remain unclear. Here, authors show that social reward and drug relapse activate distinct dopaminergic ...

❗ NEWS︱Nature Communications
👏 Why Does Social Interaction Prevent Relapse? Prof. Yanxue Xue’s Team Uncovers Key Mechanism of Dopamine “Mutual Competition”.
BrainVTA website: www.brainvta.tech
👇MORE
www.nature.com/articles/s41...

Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity - Molecular Psychiatry Molecular Psychiatry - Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity

❗NEWS︱Molecular Psychiatry
👏Does the Liver "Remotely Control" Depression? Prof. Fang Wang’s Team Uncovers a Novel Mechanism in the Liver-Brain Axis: Complement C3 Disrupts the Blood-Brain Barrier, Exacerbating Depression.
BrainVTA website: www.brainvta.tech
👇MORE
www.nature.com/articles/s41...

Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin In Alzheimer’s disease (AD), glial crosstalk surrounding amyloid-β (Aβ) plaques establishes a self-reinforcing inflammatory circuit; however, its underlying mechanisms are incompletely understood. Zha...

❗NEWS︱Immunity
👏Prof. Jing Zhang’s Team Uncovers a Novel Mechanism by Which Astrocytes Promote Microglial Inflammatory Activity and Exacerbate Amyloid Pathology.
👇MORE
www.cell.com/immunity/abs...

🔥Lots of Pre-made AAVs
Check out catalog:
brainvta.tech/plus/list.ph...
📌Shipping from Maryland or China, delivered in 3-7 days!
🔥AAV-HBV/Pseudo- LV/VSV-coronavirus
🔥Customized large-scale AAV/LV/Ad packaging
Email: sales@brainvta.com