#AACR26 #CityOfHope #TGen @tgenresearch.bsky.social @cityofhope.bsky.social
Posts by Heini M Natri
First day of AACR: spatial and pups.
@hggadvances.bsky.social's latest article provides systematic evidence that sex-differentiated somatic regulation underlies tumor-intrinsic mechanisms in multiple myeloma, reinforcing the need for sex-aware molecular analyses in precision medicine: https://bit.ly/4s6j2VE #ASH #HumanGenetics
We frame autism as an emergent property of complex adaptive systems rather than a discrete condition with linear causes, and argue that autism health disparities stem from chronic mismatch between regulatory architecture and environmental demand. Now out in Autism in Adulthood. 2/3
New publication! Lead by Lori Hogencamp, we present the Evolutionary Stress Framework, a complexity-based model that reframes neurodevelopmental variation as the emergent outcome of stress–energy regulation and predictive processing over time. 1/3
Should biology put complexity first? www.sciencedirect.com/science/arti... - excellent essay by @philipcball.bsky.social. I would add epistasis to polygenicity and pleiotropy as a ubiquitous and fundamental phenomenon, not some optional complication that we can try to account for afterwards
Important and alarming autism news from @rosebroderick.bsky.social at @statnews.com www.statnews.com/2026/01/23/k...
I would appreciate if the members of the committee could elaborate and clarify if their goal is truly to “fight against autism”
The idea that America needs to occupy Greenland because we actually care enough about native people and want to build oncology centers is enough to make your head fully explode
The group will produce guidance to support researchers navigating ethical, legal, social, and practical considerations in human genetics and genomics. The work will be published in the American Journal of Human Genetics. I'm looking forward to meeting the group and collaborating in 2026! 2/2
I'm happy to share that I will be serving in an ASHG @geneticssociety.bsky.social professional guidance writing group on the participation of people with disabilities in genomics and precision medicine research. 1/2
Join our January #ELSIFridayForum: how genetic embryo selection is being shaped by commercial incentives, regulatory gaps, and shifting cultural expectations of parenthood.
January 9th, 2026; 12pm ET/9am PT
Register: www.addevent.com/event/kct18q...
Why are more young adults getting appendix cancer? In the latest Cancerwise podcast episode, our experts explain why this rare cancer is often missed and share the latest treatment advances.
Listen now: spr.ly/6014COB7p #EndCancer
HAPPY HOLIDAYS TO ALL OF YOU!🎄✨
One journal editor in chief called the results “concerning,” while another thought the analysis was looking for problems on purpose.
New pathway discovered!
What Other Diagnoses Could Learn From Autism’s Diagnostic Appeal
The role of cognitive-perceptual mechanistic explanations
A response by Riva Stoudt to my autism differential diagnosis post
www.psychiatrymargins.com/p/what-other...
💯🙌
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
Thank you, I meant to use the url.
@drstevenkapp.bsky.social
@kgillyn.bsky.social
I hope you find this interesting and helpful! Most of my co-authors are not on Bluesky, but. I'll tag those who do here. 8/8
@docautie.bsky.social
This manuscript is a result of the unwavering commitment of many amazing scholars. Special thanks to my co-first author Sinéad O’Brien and senior author Kristen Gillespie-Lynch, and congratulations to the whole team for bringing this often very difficult project to a conclusion. 7/
We provide recommendations for each stage of research, from grant writing to dissemination. We recognize that continuing to share our challenges and strategies to address them is critical for improving representation, capacity, and accountability, and to promote authentically participatory work. 6/
…we identified shared differences across three broad categories: Representation (e.g., lack of meaningful power sharing), Capacity (e.g., insufficient time and knowledge), and Accountability (e.g., limited follow-through). 5/
Despite the differences between the two initiatives (a small-scale study utilizing participatory approaches to develop a Game Design and Employment Workshop for Autistic youth, and b) a national research network seeking to drive autism research informed by Autistic “insider-researchers”)... 4/
We created collaborative documents to facilitate discussions on difficult topics and to identify shared values, define respectful communication, interrogate power dynamics, and implement accountability processes. Our materials, including blank templates, are included as Supplementary Files. 3/